"VEXAS" meaning in English

{
  "etymology_text": "First discovered in October 2020, with the report from The New England Journal of Medicine and identified by a multidisciplinary team of scientists (see quotations below).",
  "head_templates": [
    {
      "args": {
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      },
      "expansion": "VEXAS (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        {
          "kind": "other",
          "name": "English entries with incorrect language header",
          "parents": [
            "Entries with incorrect language header",
            "Entry maintenance"
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          "source": "w"
        },
        {
          "kind": "topical",
          "langcode": "en",
          "name": "Biology",
          "orig": "en:Biology",
          "parents": [
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            "All topics",
            "Fundamental"
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          "source": "w"
        },
        {
          "kind": "topical",
          "langcode": "en",
          "name": "Medicine",
          "orig": "en:Medicine",
          "parents": [
            "Biology",
            "Sciences",
            "All topics",
            "Fundamental"
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          "source": "w"
        }
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      "examples": [
        {
          "ref": "2020 October 27, David B. Beck, Marcela A. Ferrada, Keith A. Sikora, Amanda K. Ombrello, et alia, “Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease”, in New England Journal of Medicine, volume 383, →DOI",
          "text": "Using a genotype-driven approach, we identified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes. We named this genetic disorder the VEXAS syndrome, which is caused by myeloid-restricted somatic missense mutations in UBA1.",
          "type": "quotation"
        },
        {
          "ref": "2021 July 1, Peter C. Grayson, Bhavisha A. Patel, Neal S. Young, “VEXAS syndrome”, in Blood, volume 137, number 26, →DOI, page 3591",
          "text": "Additionally, patients with VEXAS suffer from a spectrum of hematologic problems, including macrocytic anemia, thrombocytopenia, thromboembolic disease, and progressive bone marrow failure, which can evolve to hematologic malignancy",
          "type": "quotation"
        },
        {
          "ref": "2023 February 14, Vicki Contie, “VEXAS syndrome more common than realized”, in National Institutes of Health",
          "text": "The researchers note that a diagnosis based on symptoms alone could easily miss cases of VEXAS that would be caught by UBA1 testing.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "An autoimmune disease that causes inflammation in the body and mostly affects men."
      ],
      "id": "en-VEXAS-en-noun-CH1WzPZ-",
      "links": [
        [
          "medicine",
          "medicine"
        ],
        [
          "biology",
          "biology"
        ]
      ],
      "raw_glosses": [
        "(medicine, biology) An autoimmune disease that causes inflammation in the body and mostly affects men."
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "biology",
        "medicine",
        "natural-sciences",
        "sciences"
      ]
    }
  ],
  "word": "VEXAS"
}

{
  "etymology_text": "First discovered in October 2020, with the report from The New England Journal of Medicine and identified by a multidisciplinary team of scientists (see quotations below).",
  "head_templates": [
    {
      "args": {
        "1": "-"
      },
      "expansion": "VEXAS (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        "English entries with incorrect language header",
        "English lemmas",
        "English nouns",
        "English terms with quotations",
        "English uncountable nouns",
        "en:Biology",
        "en:Medicine"
      ],
      "examples": [
        {
          "ref": "2020 October 27, David B. Beck, Marcela A. Ferrada, Keith A. Sikora, Amanda K. Ombrello, et alia, “Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease”, in New England Journal of Medicine, volume 383, →DOI",
          "text": "Using a genotype-driven approach, we identified a disorder that connects seemingly unrelated adult-onset inflammatory syndromes. We named this genetic disorder the VEXAS syndrome, which is caused by myeloid-restricted somatic missense mutations in UBA1.",
          "type": "quotation"
        },
        {
          "ref": "2021 July 1, Peter C. Grayson, Bhavisha A. Patel, Neal S. Young, “VEXAS syndrome”, in Blood, volume 137, number 26, →DOI, page 3591",
          "text": "Additionally, patients with VEXAS suffer from a spectrum of hematologic problems, including macrocytic anemia, thrombocytopenia, thromboembolic disease, and progressive bone marrow failure, which can evolve to hematologic malignancy",
          "type": "quotation"
        },
        {
          "ref": "2023 February 14, Vicki Contie, “VEXAS syndrome more common than realized”, in National Institutes of Health",
          "text": "The researchers note that a diagnosis based on symptoms alone could easily miss cases of VEXAS that would be caught by UBA1 testing.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "An autoimmune disease that causes inflammation in the body and mostly affects men."
      ],
      "links": [
        [
          "medicine",
          "medicine"
        ],
        [
          "biology",
          "biology"
        ]
      ],
      "raw_glosses": [
        "(medicine, biology) An autoimmune disease that causes inflammation in the body and mostly affects men."
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "biology",
        "medicine",
        "natural-sciences",
        "sciences"
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    }
  ],
  "word": "VEXAS"
}