"parthanatos" meaning in English

{
  "etymology_templates": [
    {
      "args": {
        "1": "en",
        "2": "PAR",
        "3": "Thanatos",
        "t2": "Greek personification of death"
      },
      "expansion": "Blend of PAR + Thanatos (“Greek personification of death”)",
      "name": "blend"
    }
  ],
  "etymology_text": "Blend of PAR + Thanatos (“Greek personification of death”)",
  "head_templates": [
    {
      "args": {
        "1": "-"
      },
      "expansion": "parthanatos (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        {
          "kind": "other",
          "name": "English blends",
          "parents": [],
          "source": "w"
        },
        {
          "kind": "other",
          "name": "English entries with incorrect language header",
          "parents": [
            "Entries with incorrect language header",
            "Entry maintenance"
          ],
          "source": "w"
        },
        {
          "kind": "topical",
          "langcode": "en",
          "name": "Physiology",
          "orig": "en:Physiology",
          "parents": [
            "Biology",
            "Medicine",
            "Sciences",
            "All topics",
            "Fundamental"
          ],
          "source": "w"
        }
      ],
      "examples": [
        {
          "ref": "2006, Seong-Woon Yu, “Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death”, in PNAS, volume 103, number 48",
          "text": "Our results suggest that excessive activation of PARP-1 leads to an intrinsic cell death program, which we designate as parthanatos to distinguish from necrosis and apoptosis.",
          "type": "quotation"
        },
        {
          "ref": "2008, Gary E. Gibson, Mitochondria and Oxidative Stress in Neurodegenerative Disorders",
          "text": "Also, the lack of knowledge of mechanisms of calpain activation in parthanatos makes it difficult to identify calpain as PAR-dependent mediators of AIF release.",
          "type": "quotation"
        },
        {
          "ref": "2010, Denson G. Fujikawa, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms",
          "text": "The biochemical features of parthanatos are distinct from classically defined pathways of cell death, and include rapid PARP-1 activation, early PAR accumulation, mitochondrial depolarization, early nuclear AIF translocation, loss of cellular NAD and ATP, and late caspase activation.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "A form of apoptosis associated with PARP."
      ],
      "id": "en-parthanatos-en-noun-g9downdK",
      "links": [
        [
          "physiology",
          "physiology"
        ],
        [
          "apoptosis",
          "apoptosis"
        ],
        [
          "PARP",
          "PARP"
        ]
      ],
      "raw_glosses": [
        "(physiology) A form of apoptosis associated with PARP."
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "medicine",
        "physiology",
        "sciences"
      ]
    }
  ],
  "word": "parthanatos"
}

{
  "etymology_templates": [
    {
      "args": {
        "1": "en",
        "2": "PAR",
        "3": "Thanatos",
        "t2": "Greek personification of death"
      },
      "expansion": "Blend of PAR + Thanatos (“Greek personification of death”)",
      "name": "blend"
    }
  ],
  "etymology_text": "Blend of PAR + Thanatos (“Greek personification of death”)",
  "head_templates": [
    {
      "args": {
        "1": "-"
      },
      "expansion": "parthanatos (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        "English blends",
        "English entries with incorrect language header",
        "English lemmas",
        "English nouns",
        "English terms with quotations",
        "English uncountable nouns",
        "en:Physiology"
      ],
      "examples": [
        {
          "ref": "2006, Seong-Woon Yu, “Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death”, in PNAS, volume 103, number 48",
          "text": "Our results suggest that excessive activation of PARP-1 leads to an intrinsic cell death program, which we designate as parthanatos to distinguish from necrosis and apoptosis.",
          "type": "quotation"
        },
        {
          "ref": "2008, Gary E. Gibson, Mitochondria and Oxidative Stress in Neurodegenerative Disorders",
          "text": "Also, the lack of knowledge of mechanisms of calpain activation in parthanatos makes it difficult to identify calpain as PAR-dependent mediators of AIF release.",
          "type": "quotation"
        },
        {
          "ref": "2010, Denson G. Fujikawa, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms",
          "text": "The biochemical features of parthanatos are distinct from classically defined pathways of cell death, and include rapid PARP-1 activation, early PAR accumulation, mitochondrial depolarization, early nuclear AIF translocation, loss of cellular NAD and ATP, and late caspase activation.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "A form of apoptosis associated with PARP."
      ],
      "links": [
        [
          "physiology",
          "physiology"
        ],
        [
          "apoptosis",
          "apoptosis"
        ],
        [
          "PARP",
          "PARP"
        ]
      ],
      "raw_glosses": [
        "(physiology) A form of apoptosis associated with PARP."
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "medicine",
        "physiology",
        "sciences"
      ]
    }
  ],
  "word": "parthanatos"
}