"original antigenic sin" meaning in English

{
  "etymology_text": "See original sin.",
  "head_templates": [
    {
      "args": {
        "1": "-"
      },
      "expansion": "original antigenic sin (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        {
          "kind": "other",
          "name": "English entries with incorrect language header",
          "parents": [
            "Entries with incorrect language header",
            "Entry maintenance"
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          "source": "w"
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          "source": "w"
        },
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        {
          "kind": "topical",
          "langcode": "en",
          "name": "Immunology",
          "orig": "en:Immunology",
          "parents": [
            "Medicine",
            "Biology",
            "Healthcare",
            "Sciences",
            "Health",
            "All topics",
            "Body",
            "Fundamental"
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          "source": "w"
        }
      ],
      "glosses": [
        "The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system \"trapped\" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections."
      ],
      "id": "en-original_antigenic_sin-en-noun-OYpPBykA",
      "links": [
        [
          "immunology",
          "immunology"
        ],
        [
          "propensity",
          "propensity"
        ],
        [
          "immune system",
          "immune system"
        ],
        [
          "preferentially",
          "preferentially"
        ],
        [
          "immunological",
          "immunological"
        ],
        [
          "memory",
          "memory"
        ],
        [
          "previous",
          "previous"
        ],
        [
          "infection",
          "infection"
        ],
        [
          "foreign",
          "foreign"
        ],
        [
          "pathogen",
          "pathogen"
        ],
        [
          "antigen",
          "antigen"
        ]
      ],
      "raw_glosses": [
        "(immunology) The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system \"trapped\" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections."
      ],
      "synonyms": [
        {
          "tags": [
            "initialism"
          ],
          "word": "Hoskins effect"
        },
        {
          "word": "OAS"
        }
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "immunology",
        "medicine",
        "sciences"
      ]
    }
  ],
  "word": "original antigenic sin"
}

{
  "etymology_text": "See original sin.",
  "head_templates": [
    {
      "args": {
        "1": "-"
      },
      "expansion": "original antigenic sin (uncountable)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        "English entries with incorrect language header",
        "English lemmas",
        "English multiword terms",
        "English nouns",
        "English uncountable nouns",
        "Pages with 1 entry",
        "Pages with entries",
        "en:Immunology"
      ],
      "glosses": [
        "The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system \"trapped\" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections."
      ],
      "links": [
        [
          "immunology",
          "immunology"
        ],
        [
          "propensity",
          "propensity"
        ],
        [
          "immune system",
          "immune system"
        ],
        [
          "preferentially",
          "preferentially"
        ],
        [
          "immunological",
          "immunological"
        ],
        [
          "memory",
          "memory"
        ],
        [
          "previous",
          "previous"
        ],
        [
          "infection",
          "infection"
        ],
        [
          "foreign",
          "foreign"
        ],
        [
          "pathogen",
          "pathogen"
        ],
        [
          "antigen",
          "antigen"
        ]
      ],
      "raw_glosses": [
        "(immunology) The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system \"trapped\" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections."
      ],
      "synonyms": [
        {
          "tags": [
            "initialism"
          ],
          "word": "Hoskins effect"
        },
        {
          "word": "OAS"
        }
      ],
      "tags": [
        "uncountable"
      ],
      "topics": [
        "immunology",
        "medicine",
        "sciences"
      ]
    }
  ],
  "word": "original antigenic sin"
}