"homodeletion" meaning in English

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      "expansion": "Blend of homozygous + deletion",
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  "etymology_text": "Blend of homozygous + deletion",
  "forms": [
    {
      "form": "homodeletions",
      "tags": [
        "plural"
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  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
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          "text": "The study identified a homodeletion in the CDKN2A gene, which is associated with an increased risk of certain cancers.",
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          "ref": "2004 August 6, Neil C. Jones, Pavel A. Pevzner, An Introduction to Bioinformatics Algorithms, MIT Press, page 220:",
          "text": "Define homodeletion as an operation of deleting a run of the same nucleotide and homoinsertion as an operation of inserting a run of the same nucleotide.",
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          "ref": "2019 April 29, Ojo, Diane, Rodriguez, David, Wei, Fengxiang, Bane, Anita, Tang, Damu1, “Downregulation of CYB5D2 is associated with breast cancer progression.”, in Scientific Reports, volume 9, number 1, page 10:",
          "text": "While homodeletion of CYB5D2 can be detected in both the TCGA (8/1093=0.7%) and Metabric (4/2051=0.2%) datasets, the frequency is low; nonetheless, in both cohorts homodeletion in TP53 was not detected.",
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          "ref": "2025 Feb, Poma, Anello Marcello, Bruno, Rossella, Petrini, Iacopo, Di Stefano, Iosè, Celi, Alessandra, Sbrana, Andrea, Cappelli, Sabrina, Chella, Antonio, Melfi, Franca, Lucchi, Marco, Alì, Greta, “Prognostic Stratification of Epithelioid Pleural Mesothelioma Based on the Hippo-TEADs Network.”, in Cancers, volume 17, number 3, page 469:",
          "text": "These tumors often harbor homodeletion of Hippo core suppressors.",
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        }
      ],
      "glosses": [
        "A type of chromosomal deletion where both copies (alleles) of a particular DNA sequence are lost from an individual's genome."
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        "(genetics) A type of chromosomal deletion where both copies (alleles) of a particular DNA sequence are lost from an individual's genome."
      ],
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  "sounds": [
    {
      "ipa": "/ˌhoʊmoʊdɪˈliːʃən/"
    }
  ],
  "word": "homodeletion"
}

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  ],
  "etymology_text": "Blend of homozygous + deletion",
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              7,
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            ]
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          "text": "Define homodeletion as an operation of deleting a run of the same nucleotide and homoinsertion as an operation of inserting a run of the same nucleotide.",
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              6,
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          "text": "While homodeletion of CYB5D2 can be detected in both the TCGA (8/1093=0.7%) and Metabric (4/2051=0.2%) datasets, the frequency is low; nonetheless, in both cohorts homodeletion in TP53 was not detected.",
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          "text": "These tumors often harbor homodeletion of Hippo core suppressors.",
          "type": "quote"
        }
      ],
      "glosses": [
        "A type of chromosomal deletion where both copies (alleles) of a particular DNA sequence are lost from an individual's genome."
      ],
      "links": [
        [
          "genetics",
          "genetics"
        ],
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          "chromosomal",
          "chromosomal"
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          "deletion"
        ],
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          "alleles",
          "alleles"
        ],
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          "genome",
          "genome"
        ]
      ],
      "raw_glosses": [
        "(genetics) A type of chromosomal deletion where both copies (alleles) of a particular DNA sequence are lost from an individual's genome."
      ],
      "tags": [
        "countable",
        "uncountable"
      ],
      "topics": [
        "biology",
        "genetics",
        "medicine",
        "natural-sciences",
        "sciences"
      ]
    }
  ],
  "sounds": [
    {
      "ipa": "/ˌhoʊmoʊdɪˈliːʃən/"
    }
  ],
  "word": "homodeletion"
}