See Lipinski's rule of five in All languages combined, or Wiktionary
{ "etymology_text": "The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.", "head_templates": [ { "args": {}, "expansion": "Lipinski's rule of five", "name": "en-proper noun" } ], "lang": "English", "lang_code": "en", "pos": "name", "senses": [ { "categories": [ { "kind": "other", "name": "English entries with incorrect language header", "parents": [ "Entries with incorrect language header", "Entry maintenance" ], "source": "w" }, { "kind": "other", "name": "Pages with 1 entry", "parents": [], "source": "w" }, { "kind": "other", "name": "Pages with entries", "parents": [], "source": "w" }, { "kind": "topical", "langcode": "en", "name": "Chemistry", "orig": "en:Chemistry", "parents": [ "Sciences", "All topics", "Fundamental" ], "source": "w" } ], "glosses": [ "A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "id": "en-Lipinski's_rule_of_five-en-name-Uwzxk3dH", "links": [ [ "chemistry", "chemistry" ], [ "rule of thumb", "rule of thumb" ], [ "chemical compound", "chemical compound" ], [ "oral", "oral" ], [ "active", "active" ], [ "drug", "drug" ] ], "raw_glosses": [ "(chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "synonyms": [ { "word": "Pfizer's rule of five" }, { "word": "RO5" }, { "word": "rule of five" } ], "topics": [ "chemistry", "natural-sciences", "physical-sciences" ], "wikipedia": [ "Lipinski's rule of five" ] } ], "word": "Lipinski's rule of five" }
{ "etymology_text": "The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.", "head_templates": [ { "args": {}, "expansion": "Lipinski's rule of five", "name": "en-proper noun" } ], "lang": "English", "lang_code": "en", "pos": "name", "senses": [ { "categories": [ "English entries with incorrect language header", "English eponyms", "English lemmas", "English multiword terms", "English proper nouns", "English uncountable nouns", "Pages with 1 entry", "Pages with entries", "en:Chemistry" ], "glosses": [ "A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "links": [ [ "chemistry", "chemistry" ], [ "rule of thumb", "rule of thumb" ], [ "chemical compound", "chemical compound" ], [ "oral", "oral" ], [ "active", "active" ], [ "drug", "drug" ] ], "raw_glosses": [ "(chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "synonyms": [ { "word": "Pfizer's rule of five" }, { "word": "RO5" }, { "word": "rule of five" } ], "topics": [ "chemistry", "natural-sciences", "physical-sciences" ], "wikipedia": [ "Lipinski's rule of five" ] } ], "word": "Lipinski's rule of five" }
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This page is a part of the kaikki.org machine-readable English dictionary. This dictionary is based on structured data extracted on 2025-01-25 from the enwiktionary dump dated 2025-01-20 using wiktextract (c15a5ce and 5c11237). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.
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