See Lipinski's rule of five on Wiktionary
{ "etymology_text": "The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.", "head_templates": [ { "args": {}, "expansion": "Lipinski's rule of five", "name": "en-proper noun" } ], "lang": "English", "lang_code": "en", "pos": "name", "senses": [ { "categories": [ { "kind": "other", "name": "English entries with incorrect language header", "parents": [ "Entries with incorrect language header", "Entry maintenance" ], "source": "w" }, { "kind": "other", "name": "Pages with 1 entry", "parents": [], "source": "w" }, { "kind": "other", "name": "Pages with entries", "parents": [], "source": "w" }, { "kind": "topical", "langcode": "en", "name": "Chemistry", "orig": "en:Chemistry", "parents": [ "Sciences", "All topics", "Fundamental" ], "source": "w" } ], "glosses": [ "A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "id": "en-Lipinski's_rule_of_five-en-name-Uwzxk3dH", "links": [ [ "chemistry", "chemistry" ], [ "rule of thumb", "rule of thumb" ], [ "chemical compound", "chemical compound" ], [ "oral", "oral" ], [ "active", "active" ], [ "drug", "drug" ] ], "raw_glosses": [ "(chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "synonyms": [ { "word": "Pfizer's rule of five" }, { "word": "RO5" }, { "word": "rule of five" } ], "topics": [ "chemistry", "natural-sciences", "physical-sciences" ], "wikipedia": [ "Lipinski's rule of five" ] } ], "word": "Lipinski's rule of five" }
{ "etymology_text": "The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria.", "head_templates": [ { "args": {}, "expansion": "Lipinski's rule of five", "name": "en-proper noun" } ], "lang": "English", "lang_code": "en", "pos": "name", "senses": [ { "categories": [ "English entries with incorrect language header", "English eponyms", "English lemmas", "English multiword terms", "English proper nouns", "English uncountable nouns", "Pages with 1 entry", "Pages with entries", "en:Chemistry" ], "glosses": [ "A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "links": [ [ "chemistry", "chemistry" ], [ "rule of thumb", "rule of thumb" ], [ "chemical compound", "chemical compound" ], [ "oral", "oral" ], [ "active", "active" ], [ "drug", "drug" ] ], "raw_glosses": [ "(chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5." ], "synonyms": [ { "word": "Pfizer's rule of five" }, { "word": "RO5" }, { "word": "rule of five" } ], "topics": [ "chemistry", "natural-sciences", "physical-sciences" ], "wikipedia": [ "Lipinski's rule of five" ] } ], "word": "Lipinski's rule of five" }
Download raw JSONL data for Lipinski's rule of five meaning in All languages combined (1.9kB)
This page is a part of the kaikki.org machine-readable All languages combined dictionary. This dictionary is based on structured data extracted on 2024-11-06 from the enwiktionary dump dated 2024-10-02 using wiktextract (fbeafe8 and 7f03c9b). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.
If you use this data in academic research, please cite Tatu Ylonen: Wiktextract: Wiktionary as Machine-Readable Structured Data, Proceedings of the 13th Conference on Language Resources and Evaluation (LREC), pp. 1317-1325, Marseille, 20-25 June 2022. Linking to the relevant page(s) under https://kaikki.org would also be greatly appreciated.