"Lipinski's rule of five" meaning in All languages combined

See Lipinski's rule of five on Wiktionary

Proper name [English]

Etymology: The rule was formulated by Christopher A. Lipinski in 1997. Five refers to the multiples of five that occur in all of the criteria. Head templates: {{en-proper noun}} Lipinski's rule of five
  1. (chemistry) A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5. Wikipedia link: Lipinski's rule of five Categories (topical): Chemistry Synonyms: Pfizer's rule of five, RO5, rule of five
    Sense id: en-Lipinski's_rule_of_five-en-name-Uwzxk3dH Categories (other): English entries with incorrect language header, Pages with 1 entry, Pages with entries Topics: chemistry, natural-sciences, physical-sciences

Alternative forms

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        "A rule of thumb stating that a chemical compound is likely to be an orally active drug in humans unless it violates more than one of these criteria: (i) no more than 5 hydrogen bond donors (the total number of nitrogen–hydrogen and oxygen–hydrogen bonds); (ii) no more than 10 hydrogen bond acceptors (all nitrogen or oxygen atoms); (iii) a molecular mass less than 500 daltons; (iv) an octanol-water partition coefficient (log P) that does not exceed 5."
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Download raw JSONL data for Lipinski's rule of five meaning in All languages combined (1.9kB)


This page is a part of the kaikki.org machine-readable All languages combined dictionary. This dictionary is based on structured data extracted on 2024-11-06 from the enwiktionary dump dated 2024-10-02 using wiktextract (fbeafe8 and 7f03c9b). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.

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