See senolytic in All languages combined, or Wiktionary
Download JSON data for senolytic meaning in English (5.1kB)
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"etymology_text": "seno- + -lytic.",
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{
"ref": "2020, Anna Chang, Current Diagnosis and Treatment: Geriatrics, 3rd edition, McGraw Hill Professional, page 186",
"text": "A number of senolytics have been identified by high-throughput screening or by targeting unique aspects of senescent cell biology.",
"type": "quotation"
},
{
"text": "2022, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin, Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes, Zhen Li, Laura Creemers, Xiaoling Zhang (editors), Regenerative Medicine for Cartilage and Joint Repair, Frontiers in Bioengineering and Biotechnology, page 14,\nTherefore, the treatment with senolytics may not be able to reverse the loss of chondrogenic potential in PDL9."
},
{
"text": "2023, Arda Küçükgüven, Íbrahim Vargel, 16: Antiaging: Is it possible?, Ibrahim Vargel, Fatma Figen Özgür (editor), Beauty, Aging and AntiAging, Elsevier (Academic Press), page 157,\nIt is important to reevaluate the efficacy of these senolytics for long-term use in antiaging, particularly if they were originally developed for short-term use."
}
],
"glosses": [
"Any drug that destroys senescent cells."
],
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"raw_glosses": [
"(medicine) Any drug that destroys senescent cells."
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],
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"senolytic"
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"word": "senolytic"
}
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"examples": [
{
"ref": "2020, O. S. Barrera-Vázquez, Juan Carlos Gomez-Verjan, “12: Pharmacological Treatment for Aging: Are We There?”, in Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura, editors, Clinical Genetics and Genomics of Aging, Springer, page 239",
"text": "Senolytic compounds are agents that selectively induce death in senescent cells [69].",
"type": "quotation"
},
{
"ref": "2022, Naomasa Fukase et al., “Chapter 3: Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System”, in Kunihiro Sakuma, Nobuo Morotomi, editors, Muscle Cell and Tissue, IntechOpen, page 34",
"text": "The use of senolytic agents is a promising approach to delay aging and reduce the severity of chronic diseases through senescent cell depletion [58].",
"type": "quotation"
},
{
"text": "2022, Jacques Ferreira, Alex Deamer, Chapter 13: Clearance of senescent cells: potent anti-aging approach, Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra (editors), Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, Elsevier (Academic Press), page 299,\nHowever, fisetin, a quercetin derivative, is moderately senolytic to many cell types, including mesenchyme-derived cells (Sasaki, Sato, & Nakanuma, 2020; Yousefzadeh et al., 2018), despite only differing by a hydroxyl group."
}
],
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"That destroys senescent cells."
],
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"(medicine) That destroys senescent cells."
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"word": "senolysis"
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"type": "quotation"
},
{
"text": "2022, Yuzhao Huang, Yuchen He, Meagan J. Makarcyzk, Hang Lin, Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes, Zhen Li, Laura Creemers, Xiaoling Zhang (editors), Regenerative Medicine for Cartilage and Joint Repair, Frontiers in Bioengineering and Biotechnology, page 14,\nTherefore, the treatment with senolytics may not be able to reverse the loss of chondrogenic potential in PDL9."
},
{
"text": "2023, Arda Küçükgüven, Íbrahim Vargel, 16: Antiaging: Is it possible?, Ibrahim Vargel, Fatma Figen Özgür (editor), Beauty, Aging and AntiAging, Elsevier (Academic Press), page 157,\nIt is important to reevaluate the efficacy of these senolytics for long-term use in antiaging, particularly if they were originally developed for short-term use."
}
],
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"Any drug that destroys senescent cells."
],
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"(medicine) Any drug that destroys senescent cells."
],
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"senolytic"
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"word": "senolytic"
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{
"word": "senolysis"
},
{
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{
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{
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"text": "Senolytic compounds are agents that selectively induce death in senescent cells [69].",
"type": "quotation"
},
{
"ref": "2022, Naomasa Fukase et al., “Chapter 3: Interventional Strategies to Delay Aging-Related Dysfunctions of the Musculoskeletal System”, in Kunihiro Sakuma, Nobuo Morotomi, editors, Muscle Cell and Tissue, IntechOpen, page 34",
"text": "The use of senolytic agents is a promising approach to delay aging and reduce the severity of chronic diseases through senescent cell depletion [58].",
"type": "quotation"
},
{
"text": "2022, Jacques Ferreira, Alex Deamer, Chapter 13: Clearance of senescent cells: potent anti-aging approach, Sandeep Kumar Singh, Chih Li Lin, Shailendra Kumar Mishra (editors), Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging, Elsevier (Academic Press), page 299,\nHowever, fisetin, a quercetin derivative, is moderately senolytic to many cell types, including mesenchyme-derived cells (Sasaki, Sato, & Nakanuma, 2020; Yousefzadeh et al., 2018), despite only differing by a hydroxyl group."
}
],
"glosses": [
"That destroys senescent cells."
],
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[
"medicine",
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],
[
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],
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"raw_glosses": [
"(medicine) That destroys senescent cells."
],
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"wikipedia": [
"senolytic"
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}
This page is a part of the kaikki.org machine-readable English dictionary. This dictionary is based on structured data extracted on 2024-06-04 from the enwiktionary dump dated 2024-05-02 using wiktextract (e9e0a99 and db5a844). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.
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