See binimetinib in All languages combined, or Wiktionary
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"text": "Binimetinib (MEK162; ARRY-438162) is a potent, adenosine triphosphate-uncompetitive, highly selective allosteric inhibitor of MEK1/2 with demonstrated on-target activity in vitro and in vivo, including models of cancer [...] In vivo, binimetinib displays broad anti-tumour activity in xenograft models derived from melanoma, colorectal cancer, non-small cell lung cancer (NSCLC), fibrosarcoma, cholangiocarcinoma, and pancreatic cancer. These non-clinical data support the use of binimetinib in a wide variety of tumour types, with a priority in tumours with aberrantly activated MAPK pathway signalling.",
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"text": "Under development are binimetinib, a MEK inhibitor being studied in patients with NRAS-mutant melanoma, and encorafinib, a BRAF inhibitor being used in combination with binimetinib for patients with BRAF-mutant melanoma.",
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"text": "Binimetinib is an oral reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK) 1/2. [...] Binimetinib inhibits MEK 1/2 downstream from BRAF and halts cancer cell signaling and survival. [...] Binimetinib is approved in combination with encorafenib, a BRAF inhibitor, for the treatment of unresectable or metastatic melanoma with a BRAF V600E/K mutation, as detected by an FDA-approved test.",
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"text": "Binimetinib is an oral reversible inhibitor of mitogen-activated extracellular signal-regulated kinase (MEK) 1/2. [...] Binimetinib inhibits MEK 1/2 downstream from BRAF and halts cancer cell signaling and survival. [...] Binimetinib is approved in combination with encorafenib, a BRAF inhibitor, for the treatment of unresectable or metastatic melanoma with a BRAF V600E/K mutation, as detected by an FDA-approved test.",
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"text": "Special Considerations [...] 7. Monitor patients for an increased risk of new primary cancers, both cutaneous and non-cutaneous, while on therapy and for up to 6 months following the last dose of binimetinib. [...] 10. Baseline and periodic CPK levels while on therapy, as rhabdomyolysis has been observed with binimetinib therapy.",
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"text": "Binimetinib is given in combination with encorafenib as each drug targets a different kinase in the RAS/RAF/MEK/ERK pathway to stop malignant cell proliferation and to tell the cells to die (undergo apoptosis). [...] Terminal half-life of binimetinib is 3.5 hours. [...] No clinically significant changes in binimetinib exposure were seen in patients with severe renal impairment.",
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Download raw JSONL data for binimetinib meaning in English (7.3kB)
This page is a part of the kaikki.org machine-readable English dictionary. This dictionary is based on structured data extracted on 2024-11-06 from the enwiktionary dump dated 2024-10-02 using wiktextract (fbeafe8 and 7f03c9b). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.
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