diphyllic

diphyllic (comparative more diphyllic, superlative most diphyllic)

more diphyllic (comparative)
most diphyllic (superlative)

This led to the view that it is one of two things - viz., either a diphyllic teratoma or a true teratoma.

1915, L. G. Gunn, “Carcinoma of the Prostate”, in Transactions of the Royal Academy of Medicine in Ireland, page 377:

The most usual type is a solid tumor composed of soft, white, necrotic and hæmorrhagic tissue with a few cysts, or tiny lobules of cartilage; a thorough examination is necessary to prove a triphyllic or even a diphyllic structure.

1926, International Surgical Digest - Volumes 1-2, page 311:

Indeed, it is doubtful if this be so much as "diphyllic", since all the epithelia can be regarded as ectodermal if not epidermal: salivary glands associated with sebaceous glands (Fig. 165) and hair follicles (Fig 164) are common enough in the dermoid skin, and stomodaeal and therefore ectodermal in somatic ontogeny;

1937, George Hilaro Barlow, James P. Babington, Guy's Hospital Reports - Volume 17; Volume 87, page 67:

(medicine) Containing tissue derived from two different germinal layers.


nocturesis

en-noun

nocturesis (countable and uncountable, plural enureses)

(medicine, uncommon) Nocturnal enuresis: involuntary urination (urinary incontinence) at night, especially during sleep.

(medicine, rare) Nocturia (urinary frequency and/or urgency at night, prompting awakening and trips to the toilet).


tear line

(anatomy) The meniscus of lacrimal fluid between the eyeball and eyelid.


pseudotubercular

(pathology) Relating to pseudotuberculosis.


FIGO

Acronym of the French name Fédération Internationale de Gynécologie et d'Obstétrique

w:International Federation of Gynaecology and Obstetrics

(gynaecology, obstetrics) Acronym of International Federation of Gynaecology and Obstetrics.


AoV

(medicine, anatomy) Abbreviation of aortic valve.


CVRM

(medicine) Initialism of cardiovascular risk management.


tachiol

(medicine, obsolete) silver fluoride used as an antiseptic


HIS

(medicine, software) Initialism of hospital information system.


DICOM

(medicine, software) Acronym of Digital Imaging and Communications in Medicine. A standard for the interchange of radiological imagery and associated notations


hamartous

From Ancient Greek ἁμαρτία (hamartía) + -ous.

Seven primary brain tumors or hamartous lesions ( lipomas) were found in treated animals, with no apparent correlation with exposure to either radiation or magnetic fields.

1998, Christopher Portier, Mary S. Wolfe, Assessment of Health Effects from Exposure to Power-line Frequency Electric and Magnetic Fields, page 99:

Congenital cystic lung lesion characterized by the presence of abnormal bronchiolar structures of hamartous character and of varying size and/or distribution.

2012, Klaus Kayser, Analytical Lung Pathology, page 32:

Hemangiomas that manifest at birth often regress over the early years of life although some have a hamartous behavior – enlarging as the child grows.

2022, Nikolaos Kotsanos, Haim Sarnat, Kitae Park, Pediatric Dentistry, page 490:

(pathology) Growing in a disorganized fashion.


DEJ

dermoepidermal junction
w:dermoepidermal junction

(anatomy, dermatology) Initialism of dermoepidermal junction.


tellurist

(medicine, obsolete) A proponent of the theory of tellurism.


thanatometer

(medicine, historical) An instrument for determining whether a person is dead or merely appears so, by measuring the temperature inside the body.


hodophilic

en-adj

hodophilic (comparative more hodophilic, superlative most hodophilic)

more hodophilic (comparative)
most hodophilic (superlative)

On the basis of our own observations we are inclined to believe that the following regions lack typical short-axon neurons: […] in general, all the regions where dendrites show marked hodophilic tendencies.

1968, Geoffrey H[oward] Bourne, editor, The Structure and Function of Nervous Tissue, Volume I: Structure I, New York, N.Y., London: Academic Press, page 262:

(neurology) Of the dendrites of neurons: tending to form branches.


bimicroscope

(ophthalmology) A low magnification twin-eyepiece microscope used to examine eyes, often with a slitlamp.


MGUS

en-noun

MGUS (countable and uncountable, plural MGUSs)

(medicine) Initialism of monoclonal gammopathy of undetermined significance.


GIST

(medicine) Initialism of gastrointestinal stromal tumor.


tribasilar

(anatomy) Having or relating to three bases.


TIBC

(medicine) Initialism of total iron-binding capacity.


SCLC

SCLC (countable and uncountable, plural SCLCs)

(oncology) Initialism of small-cell lung cancer.


nondermatomal

nondermatomal distribution

(biology, medicine, of sensation or pain) Not dermatomal: not corresponding to the boundaries of neural dermatomes.


electrocardioversion

From electro- + cardioversion or electro- + cardiovert + -ion.

(medicine) Cardioversion by means of electricity (electroshocks or direct current), as opposed to chemically (pharmacologically/medically).


tympanostapedial

(anatomy) Of or pertaining to the tympanum and the stapes.


splintable

(medicine) Able to be treated with a splint.


tympanomaxillary

(anatomy) Of or pertaining to the tympanum and the maxilla.


tympanomandibular

(anatomy) Of or pertaining to the tympanum and the mandible.


tympanomalleal

(anatomy) Of or pertaining to the tympanum and the malleus.


antihyperlipoproteinemic

en-adj

antihyperlipoproteinemic (comparative more antihyperlipoproteinemic, superlative most antihyperlipoproteinemic)

more antihyperlipoproteinemic (comparative)
most antihyperlipoproteinemic (superlative)


antihyperlipoproteinemic

(pharmacology) Any drug that counters hyperlipoproteinemia.


appendicovesical

appendicovesical fistulas

(vermiform) appendix
vermiform appendix#English

(biology, medicine) Relating to the (vermiform) appendix and the urinary bladder, usually with reference to a fistula therebetween.


ureteropyelography

Contrast radiography
contrast radiography#English

(medicine) Contrast radiography of a ureter and the adjacent renal pelvis (either unilaterally or bilaterally).


panserositis

From pan- + serositis or pan- + seros(ae) + -itis.

serous membranes
serous membrane#English

Kawasaki disease
Kawasaki disease#English

(biology, medicine) Inflammation of many serosae (serous membranes), throughout the body, as a component of a systemic disease process, such as Kawasaki disease, MIS-C, or MIS-A (Multisystem Inflammatory Syndrome in Adults); thus, vasculitides, polyarthritides, and pericarditis are involved.


prediverticular

From pre- + diverticular or pre- + diverticul(um) + -ar.

prediverticular disease

prediverticular state

prediverticular stage

prediverticular phase

(biology, medicine, of diverticulosis) Present in an incipient form that has not yet progressed to formation of complete diverticula.


peridiverticular

From peri- + diverticular or peri- + diverticul(um) + -ar.

peridiverticular inflammation

peridiverticular abscess

(biology, medicine) Around a diverticulum; adjacent to a diverticulum.


postrecurrence

(medicine) After the recurrence of a condition.


prerecurrence

(medicine) Before the recurrence of a condition.


postpancreatoduodenectomy

(medicine) After a pancreatoduodenectomy.


vesicoenteral

vesicoenteral fistulas

(biology, medicine) Synonym of intestinovesical


antimannan

(biology, medicine, of antibodies) Against mannan.


enterocolonic

enterocolonic fistulas

(biology, medicine) Synonym of enterocolic.


esophagoenterostomy

en-noun

esophagoenterostomy (countable and uncountable, plural esophagoenterostomies)

Because the esophagus has no serosa, esophagoenterostomies are much higher risk.

2005, Courtney M. Townsend, David C. Sabiston, Pocket Companion to Sabiston Textbook of Surgery, Saunders, →ISBN, page 178:

(surgery) A surgical operation that involves suturing the esophagus to the duodenum and removing the stomach.


cholesterohydrothorax

(medicine) A rare condition characterized by the accumulation of chylous fluid mixed with cholesterol crystals in the pleural cavity.


rod of Asclepius

rod of Asclepius (plural rods of Asclepius)

Aesculapian staff
Aesculapian staff#English


staff of Asclepius

staff of Asclepius (plural staffs of Asclepius)


From hepatico- + cholecysto- + st- + choledocho- + -enterostomy.

af

(surgery) the surgical construction of an artificial passage between the gall bladder and hepatic duct, on the one hand, and between the intestine and the gall bladder on the other


Courvoisier's law

Named after Swiss surgeon Ludwig Georg Courvoisier (1843–1918).

named-after

(medicine) A medical observation stating that a painless palpable gallbladder accompanied with jaundice is unlikely to be caused by gallstones, implicating a possible biliary tract or pancreatic cancer.


cystoureteropyelonephritis

From cysto- (“urinary bladder”) + uretero- (“ureter”) + pyelo- (“renal pelvis”) + nephritis (“inflammation of the kidney”).

pre

urinary tract infection
urinary tract infection

(pathology) A medical condition involving inflammation or infection of the bladder, ureter, and kidney, usually caused by bacteria and occurring as a result of a urinary tract infection that spreads to the upper urinary tract.


hemangioendothelioblastoma

From hemangio- (“blood vessel”) + endothelio- (“endothelium”) + blastoma (“a tumour that is caused by malignancies in precursor cells or blasts”).

(oncology) A rare tumor composed of cells with characteristics of both endothelial cells and primitive cells, typically found in the liver or other soft tissues of the body.


hemangio-

Compound of hem- (“blood”) + angio- (“vessel”).

com+

hemangio- + blast → hemangioblast

hemangio- + -oma → hemangioma

hemangio- + sarcoma → hemangiosarcoma

(medicine) Relating to the blood vessels.


postneoadjuvant

It is conceivable that an internationally uniform procedure for handling and reporting on postneoadjuvant systemic therapy specimens would eventually resolve this issue.

2015, Provenzano, E., Bossuyt, V., Viale, G., et al., “Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group”, in Modern Pathology, volume 28, →DOI, pages 1185–1201:

(medicine) After neoadjuvant therapy as a sort of second-line complement or supplement to it, but still before the primary therapy.


postplatinum

(medicine, phase of therapy) After platinum-based therapy, that is, after treatment with a platin.


pseudoachalasia

(medicine) An esophageal condition involving the same obstructive character as achalasia but not of a primary (idiopathic) nature (cause); it is called pseudoachalasia when the term achalasia is intended to mean only the type of such obstruction that is of primary nature, whereas in other terminological schemas it is classified as a type of achalasia, called secondary achalasia in coordinate rank with primary achalasia (true achalasia).

achalasia

coordinate when not viewed as hypernymous


cementoid

(dentistry, zoology) A matrix of collagen fibres that becomes mineralised to form cementum.


cementoclast

(dentistry, zoology) A multinucleated giant cell that consumes cementum.


coenesthesiopathy

From Ancient Greek κοινός (koinós, “common”) + αἴσθησις (aísthēsis, “perception from the senses”) + πάθος (páthos, “suffering, misery, condition”).


LRTI

respiratory tract
respiratory tract#English

(medicine) Initialism of lower respiratory tract infection.


pseudorheumatoid

progressive pseudorheumatoid dysplasia (PPD)

progressive pseudorheumatoid dysplasia (PPRD)

(biology, medicine) Seemingly rheumatoid but not (that is, clinically similar but pathophysiologically different).


prostatoseminalvesiculectomy

en-noun

prostatoseminalvesiculectomy (countable and uncountable, plural prostatoseminalvesiculectomies)

From prostato + seminal + vesiculectomy.

(surgery) a surgical procedure in which the prostate gland, seminal vesicles, and ejaculatory ducts are removed


penicillin O

(pharmacology) A type of penicillin, C₁₃H₁₆N₂O₄S, isolated from Penicillium chrysogenum that is used to treat bacterial infections.


peritonealize

en-verb

peritonealize (third-person singular simple present peritonealizes, present participle peritonealizing, simple past and past participle peritonealized)

peritonealizes (present singular third-person)
peritonealizing (participle present)
peritonealized (participle past)
peritonealized (past)

(medicine) To subject to peritonealization.


underresuscitate

underresuscitate (third-person singular simple present underresuscitates, present participle underresuscitating, simple past and past participle underresuscitated)

underresuscitates (present singular third-person)
underresuscitating (participle present)
underresuscitated (participle past)
underresuscitated (past)

LL-Q1860 (eng)-Flame, not lame-underresuscitate.wav

(medicine, transitive) To administer an insufficient amount of fluid during an attempt to resuscitate (somebody).


infrabony

(dentistry) Vertical direction in bone, below the tooth.


suprabony

(dentistry) Horizontal direction in bone, adjacent to the tooth.


enterotherapy

(medicine) Therapy which aims at the intestinal regeneration and symbiosis.


HAQER

Coordinate term: HAR

(genetics, evolutionary theory) Acronym of human ancestor quickly evolved region.


ethiazide

(pharmacology) A benzothiadiazine sulfonamide diuretic.


FGR

(obstetrics) Initialism of fetal growth restriction.


postsubiculum

In addition to hippocampal inputs, the medial mammillary nuclei receive projections from the rostral subiculum, and the lateral mammillary nuclei receive projections from the pre-, para-, and postsubicula.

2018, Jill B. Rich, “Mammillary Bodies”, in Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan, editors, Encyclopedia of Clinical Neuropsychology, 2nd edition, Springer International Publishing AG, →ISBN, page 2076:

(neurology) The dorsal part of the presubiculum.


nompC

Initialism of No mechanoreceptor potential C

Drosophila melanogaster
Drosophila melanogaster#Translingual

(genetics, entomology) A gene coding for a mechanosensitive ion channel protein in Drosophila melanogaster.


avatrombopag

Aplastic anemia (AA) secondary to radiotherapy presents a difficult situation in the treatment of both the malignant tumor and AA itself. We aimed to evaluate the efficacy of avatrombopag (AVA), a thrombopoietin receptor agonist, in patients with AA secondary to chemoradiotherapy.

2023 January, Yarong Chi, Qinglin Hu, Chen Yang, Miao Chen, Bing Han, “Avatrombopag is effective in patients with chemoradiotherapy-induced aplastic anemia: a single-center, retrospective study”, in Experimental Hematology, volume 117, →DOI, page 62:

(pharmacology) A medication used to treat certain conditions that lead to thrombocytopenia.


lusutrombopag

Currently, four TPO-RAs have been launched in the United States and Europe, namely romiplostim, eltrombopag (ELT), avatrombopag (AVA), and lusutrombopag [9].


labioversion

(dentistry) The malposition of an anterior tooth away from the normal line of occlusion towards the lips.


oncogenous

oncogenous viruses

oncogenous osteomalacia

(biology, medicine) Synonym of oncogenic


alpha-gal syndrome

(pathology) A disease that causes an immunological response to alpha-gal, typically first causing gastrointestinal problems, and proceeding with other symptoms of allergies.


mammalian meat allergy

en-noun

mammalian meat allergy (countable and uncountable, plural mammalian meat allergies)

It is an allergy to the ingestion of mammalian products, such as meat, cheese, gelatin, etc. which contain alpha-gal.

alpha-gal syndrome
alpha-gal syndrome#English

(pathology) Synonym of alpha-gal syndrome


DAMA

(medicine) Initialism of discharged against medical advice.


LAMA

(medicine) Initialism of leaving/left against medical advice.


LAMA

Coordinate term: SAMA

(pharmacology) Initialism of long-acting muscarinic antagonist.


chemonaïve

(medicine) Alternative form of chemonaive


TGC

time gain compensation
w:time gain compensation

(medicine) Initialism of time gain compensation.


CEUS

contrast-enhanced ultrasound
w:contrast-enhanced ultrasound

(medicine) Initialism of contrast-enhanced ultrasound.


Meckel's diverticulum

Named after Johann Friedrich Meckel, who described the embryological origin of this type of diverticulum in 1809.

(anatomy) A slight bulge in the small intestine occasionally present at birth as a vestigial remnant of the vitelline duct.


mitochondriate

From mitochondria + -ate (adjective-forming suffix).


gender-affirming

From gender + affirming, "bringing into conformance with [the person's] gender".

Transgender youth in North Carolina would have to wait until they turn 18 to receive gender-affirming surgeries under a bill approved Wednesday by the GOP-controlled state House.

2023 May 3, “North Carolina House OKs Ban on Transgender Youth Surgeries”, in U.S. News & World Report:

We stress that reconstructive breast surgeries and testicular implants are gender-affirming interventions—rather than interventions provided through a generic form of respect for persons—because gender is a morally significant, social category that shapes how individuals regard themselves and understand each other.

2023 June 7, “Gender-Affirming Care for Cisgender People”, in Hastings Center Report, →DOI:

(medicine, especially transgender) Inducing a change in the physical gender characteristics, whether surgically, pharmaceutically, or otherwise, typically of a transgender or intersex person.


UHB

en-noun

UHB (countable and uncountable, plural UHBs)

(education, medicine) Abbreviation of university health board.

(medicine) Abbreviation of undersea and hyperbaric medicine (“diving medicine”).


CFP

CFP (countable and uncountable, plural CFPs)

ciguatera fish poisoning
w:ciguatera fish poisoning

(toxicology) Initialism of ciguatera fish poisoning.


prn

Alternative forms: PRN, p.r.n.

“‘My return fare was £171. 6s. 0d. and I enclose the counterfoil. I have no record of other expenses; the major items were chilled liquid sedatives on the flight home at 55 cents a shot. Although taken prn, the last dose I remember is the fourth.”

1988, E[dward] J[ames] Moran Campbell, Not Always on the Level, [London]: British Medical Journal, →ISBN, page 182:


escutcheonectomy

(medicine) Surgical removal of tissue from the pubic mound, a treatment for buried penis.


MoCA

Montreal Cognitive Assessment
w:Montreal Cognitive Assessment

(medicine) Acronym of Montreal Cognitive Assessment.


FES

After long bone fractures, some lung dysfunction occurs in almost all patients, ranging from minor laboratory abnormalities to full blown fat embolism syndrome (FES).

2020, chapter 66, in Michael A. Gropper, editor, Miller's anesthesia, →ISBN, page 2145:

fat embolism syndrome
w:fat embolism syndrome

(traumatology) Initialism of fat embolism syndrome.


DCN

dorsal cochlear nucleus
dorsal cochlear nucleus#English

(anatomy) Initialism of dorsal cochlear nucleus.


telestroke

(medicine) The use of telemedicine to treat a patient who has had a stroke.


magenblase

From German Magenblase (literally “stomach bubble”).


ceftaroline fosamil

(pharmacology) A prodrug of ceftaroline.


funguria

(medicine) The presence of fungus in the urine.


diclofenac epolamine

(organic chemistry, pharmacology) A prodrug of diclofenac.


andexanet alfa

(pharmacology) An antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding.


raphe pallidus

FIGURE 4. Stimulation of gastric acid secretion induced by microinjection of the stable TRH analog, RX 77368, into the raphe pallidus in urethane-anesthetized rats.

1991, Yvette Taché, David L. Wingate, Brain-Gut Interactions, CRC Press, page 175:

The raphe pallidus is located medial and ventral to the inferior olivary nuclear complex.

2013, Ken W. S. Ashwell, “5: Peripheral nervous system, spinal cord, brainstem and cerebellum”, in Ken Ashwell, editor, Neurobiology of Monotremes, CSIRO Publishing, page 91:

(anatomy, neuroanatomy) One of a cluster of nuclei (the raphe nuclei) found in the brain stem.


herxing

Shortened from Jarisch-Herxheimer reaction, which in turn derives from the names of Adolf Jarisch and Karl Herxheimer, physicians who separately described the reaction in syphilis patients.

Brenner’s own experience with “herxing” (a common phrase among Lyme patients) started 2 or 3 hours after his first antibiotic treatment.

1997 February, Edward McSweegan, “TNF antibodies get new lease”, in Nature Medicine, volume 3, number 2, page 130:

Moreover, the Jarish–Herxheimer reaction (sometimes referred to as “herxing”) is a rare syndrome seen within the first 48 hr of starting antibiotic treatment for some spirochetal diseases; the belief that “herxing” causes ongoing symptom flares in patients with Lyme disease is a fallacy for which there is no objective evidence.

2013 July, Centers for Disease Control and Prevention, “Article Corrections”, in Gifted Child Today, volume 36, number 3, page 215:

Herxes, or “herxing,” are a great bugbear in the world of chronic Lyme. The term is drawn from the Jarisch-Herxheimer reaction, originally identified in the context of syphilis. It refers to a brief, severe reaction that can take place within the first few days of antibiotic treatment; as bacteria die off and release endotoxins, a patient experiences fever, chills, and sometimes dangerously low blood pressure.

2019 July 22, Molly Fischer, “Maybe it’s Lyme”, in New York magazine:

He sets the machine to the frequency that’s supposed to kill the Lyme spirochete, turns it on, and immediately starts Herxing.

2021 December, Sam Kriss, “It’s not all in your head”, in First Things: A Monthly Journal of Religion and Public Life, page 12:

(medicine, informal) Jarisch–Herxheimer reaction, a negative reaction to antibiotic treatment.


cecopexy

en-noun

cecopexy (countable and uncountable, plural cecopexies)

(surgery) Alternative spelling of caecopexy


volvulized

en-adj

volvulized (not generally comparable, comparative more volvulized, superlative most volvulized)

more volvulized (comparative)
most volvulized (superlative)

volvulized bowel

(medicine, surgery) Synonym of volvulated


volvulize

en-verb

volvulize (third-person singular simple present volvulizes, present participle volvulizing, simple past and past participle volvulized)

volvulizes (present singular third-person)
volvulizing (participle present)
volvulized (participle past)
volvulized (past)

From vovlul(us) + -ize, ultimately from Latin volvere (“to twist round”).

(medicine, surgery) Synonym of volvulate


caeco-

From international scientific vocabulary, reflecting a New Latin combining form, from Latin caecum, as at caecum § Etymology.

classical compound
international scientific vocabulary


herx

herx (third-person singular simple present herxes, present participle herxing, simple past and past participle herxed)

herxes (present singular third-person)
herxing (participle present)
herxed (participle past)
herxed (past)

These usually last for several hours, and require little more than aspirin and bed rest. Yet many Lyme newsgroup participants write about a "herx" beginning days or weeks after the start of antibiotic therapy, and "herxing" for weeks at a time -- often in a cyclic fashion.

2017 October 1, Edward McSweegan, “Lyme Disease: Questionable Diagnosis and Treatment”, in ActionLyme.org, archived from the original on 2023-04-03:

When using any antimicrobial against any Lyme-like infection, most patients will herx at some stage.

2020, John Coleman, Rethinking Parkinson’s Disease, page 215:

Has anyone else herxed intensely even on low dose fenben?
I started with 150mg and herxed, backed down to 70mg and still herxed along with my 100mg doxy.

2021 March 4, Fredsmith, “herxing like crazy on Fenben”, in HealingWell:

Jarisch-Herxheimer reaction
Jarisch-Herxheimer reaction

(medicine, informal) To experience a Jarisch-Herxheimer reaction, a negative reaction to antibiotic treatment.


herx

For quotations using this term, see Citations:herx.

(medicine, informal) A Jarisch-Herxheimer reaction.


Heaf test

(medicine) A diagnostic skin test to determine whether a child has been exposed to tuberculosis infection, administered by means of a Heaf gun.


tine test

(medicine) A multiple-puncture tuberculin skin test used in the diagnosis of tuberculosis,


nociplastic pain

2019, Mark A. Jones, Darren A. Rivett, Clinical Reasoning in Musculoskeletal Practice, Elsevier, 2nd Edition, E-book Edition, page 40,
Nociplastic pain is clearly dysfunctional as it serves no protective benefit to the people experiencing it.
Nociplastic pain is significantly disproportionate to any plausible tissue contributions, persists beyond expected tissue healing times and may be recurrent in nature.

2022, Deeba Minhas, Daniel J. Clauw, 88: Fibromyalgia and related syndromes, Marc C. Hochberg, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman, Ellen M Gravallese, Desiree van der Heijde (editors), Rheumatology, Elsevier, 8th Edition, page 740,
Fibromyalgia (FM) is the prototypical nociplastic pain syndrome.

Thus, nociplastic pain is linked with, but not synonymous with, central sensitization. Nociplastic pain is a maladaptive nervous system dysfunction associated with altered nociceptive processing and increased responsiveness to subthreshold afferent input^(19,21,26) and is chronic by definition.

2022, Betsy Myers, June Hanks, Management of Common Orthopaedic Disorders, Wolters Kluwer, unnumbered page:

central nervous system
central nervous system

(medicine) Heightened responsiveness to sensory input, thought to result from dysfunction in the processing of pain signals by the central nervous system.

noziplastischer Schmerz

pain thought to result from dysfunction in pain signal processing


corona glandis

en-noun

corona glandis (plural coronae glandis or coronae glandum)

coronae glandis (plural)
coronae glandum (plural)

/kəˈɹəʊnə ˈɡlændɪs/

Directly from Latin corōna glandis (“crown of the glans”), glandis being a genitive.

der

corona glandis penis
corona glandis penis#English

(anatomy) Ellipsis of corona glandis penis.


corona glandis penis

en-noun

corona glandis penis (plural coronae glandis penis or coronae glandum penium)

coronae glandis penis (plural)
coronae glandum penium (plural)

/kəˈɹəʊnə ˈɡlændɪs ˈpiːnɪs/

Directly from Latin corōna glandis pēnis (“crown of the glans of the penis”), glandis and pēnis being genitives.

der

Holonym: glans penis

(anatomy) The salient part of the penile glans.


-entan

Clipping of endothelin receptor antagonist.

clipping

(pharmacology) An endothelin receptor antagonist.


aprocitentan

/ˌæpɹəsɪˈtɛntæn/

From [Term?] + -entan (“endothelin receptor antagonist”).

af

(pharmacology) An endothelin receptor antagonist researched for its effect on resistant hypertension.


darusentan

/ˌdæɹəˈsɛntæn/

(pharmacology) An endothelin receptor antagonist developed for the potential treatment of resistant hypertension.


enrasentan

/ˌɛnɹəˈsɛntæn/


fandosentan

(pharmacology) An endothelin receptor A antagonist.


nebentan

(pharmacology) A potent endothelin receptor A antagonist.


sparsentan

(pharmacology) An antagonist to endothelin receptor type A and angiotensin II receptor type 1, used in the treatment in primary immunoglobulin A nephropathy.


middle childhood

en-noun

middle childhood (usually uncountable, plural middle childhoods)

(chiefly uncountable, psychiatry, sociology) The life stage between early childhood and adolescence, often defined by sociologists as roughly encompassing the years from age 6 to 12.


praeputium clitoridis

praeputium clitoridis (plural praeputia clitoridis or praeputia clitoridum)

praeputia clitoridis (plural)
praeputia clitoridum (plural)

Directly from Latin praeputium clitoridis (“prepuce of the clitoris”), clitoridis being a genitive.

der

Holonym: clitoris

Comeronyms: corpus cavernosum clitoridis, glans clitoridis

Coordinate term: praeputium penis


praeputium penis

en-noun

praeputium penis (plural praeputia penis or praeputia penium)

praeputia penis (plural)
praeputia penium (plural)

Directly from Latin praeputium penis (“prepuce of the penis”), penis being a genitive.

der

Holonym: penis

Comeronyms: corpus cavernosum penis, glans penis

Coordinate term: praeputium clitoridis


hyperkatifeia

From hyper- + Ancient Greek κατήφεια (katḗpheia).

(medicine, pathology) Hypersensitivity to emotional distress in the context of substance abuse.


hirsuties papillaris penis

en-noun

hirsuties papillaris penis (plural hirsuties papillares penis)

Borrowed from Latin hīrsūtiēs papillāris pēnis (literally “papillary hirsutism of the penis”), pēnis being a genitive.

bor+

pearly penile papules
pearly penile papules

(medicine) The medical condition of having pearly penile papules.

hirsuties papillaris coronae glandis

papillary hirsutism of the corona of the glans


hirsuties papillaris coronae glandis

en-noun

hirsuties papillaris coronae glandis (plural hirsuties papillares coronae glandis)

hirsuties papillares coronae glandis (plural)

Borrowed from Latin hīrsūtiēs papillāris corōnae glandis (literally “papillary hirsutism of the corona of the glans”).

bor+

papillomatosis coronae glandis

papillomatosis of the corona of the glans

papillomatosis coronae penis

papillomatosis of the corona of the penis


papillae coronae glandis

en-noun

papillae coronae glandis pl (plural only)

Borrowed from Latin papillae corōnae glandis (literally “papillae of the corona of the glans”).

bor+

pearly penile papules
pearly penile papules#English

(medicine) Synonym of pearly penile papules


papillomatosis coronae penis

en-noun

papillomatosis coronae penis (plural papillomatoses coronae penis)

Borrowed from Latin papillōmatōsis corōnae pēnis (literally “papillomatosis of the corona of the penis”).

bor+

hirsuties papillaris coronae glandis#English

(medicine) Synonym of hirsuties papillaris coronae glandis


papillomatosis coronae glandis

en-noun

papillomatosis coronae glandis (plural papillomatoses coronae glandis)

Borrowed from Latin papillōmatōsis corōnae glandis (literally “papillomatosis of the corona of the glans”).


definitive treatment

en-noun

definitive treatment (countable and uncountable, plural definitive treatments)

The doctor determined the definitive treatment for the patient.

(medicine) The most suitable treatment for a specific medical condition.


biocompliant

(medicine) Not causing health complications when used in surgical implantations.


hirsutoid papillomatosis

hirsutoid papillomatosis (plural hirsutoid papillomatoses)


orchie

(surgery, transgender slang) Clipping of orchiectomy.


mossy cell

(anatomy) A kind of excitatory cell in the hilus of the dentate gyrus within the brain, thought to play a preparatory role in data retrieval.


clitoral prepuce

clitoral prepuce (plural clitoral prepuces)


supra-auricular

(anatomy) Alternative spelling of supraauricular.


Jarisch-Herxheimer reaction

Jarisch-Herxheimer reaction (plural Jarisch-Herxheimer reactions)

Named after the Austrian dermatologist Adolf Jarisch and the German dermatologist Karl Herxheimer.

(medicine) A dangerous reaction to endotoxin-like products released by the death of harmful microorganisms within the body during antibiotic treatment.


NLPHL

w:nodular lymphocyte-predominant Hodgkin lymphoma

(medicine) Initialism of nodular lymphocyte-predominant Hodgkin lymphoma.


SBP

systolic blood pressure
w:systolic blood pressure

(medicine) Initialism of systolic blood pressure.

spontaneous bacterial peritonitis
w:spontaneous bacterial peritonitis

(medicine) Initialism of spontaneous bacterial peritonitis.


FNHTR

w:febrile non-hemolytic transfusion reaction

(medicine) Initialism of febrile non-hemolytic transfusion reaction.


ALCL

anaplastic large cell lymphoma
w:anaplastic large cell lymphoma

(pathology) Initialism of anaplastic large cell lymphoma.


IHH

(genetics) Initialism of Indian hedgehog.


cutis verticis gyrata

(medicine) A medical condition involving excessive thickening of the soft tissues of the scalp, resulting in hard cerebriform ridges and furrows.


Nauheim bath

(medicine, historical) A therapeutic bath taken as part of the Nauheim treatment.


nupercaine

The method of anesthetizing the mother is as follows: When the pains are every five minutes and quite strong or the cervix is five cm. dilated along with regular and strong pains, the mother is given a block anesthesia of 1 cc. of 1:200 nupercaine, 1 cc. of 10 per cent dextrose with .05 cc. of 1:1000 adrenalin.

1951 February, Forrest H. Howard, “The Physiologic Position for Delivery”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 99:


aseptic meningitis

aseptic meningitis (countable and uncountable, plural aseptic meningitides)

(medicine) Meningitis with a negative cerebrospinal fluid (CSF) Gram stain and culture, typically caused by viruses.


SIH

(pathology) Abbreviation of spontaneous intracranial hypotension.


EBUS

(medicine) Abbreviation of endobronchial ultrasound.


Shprintzen-Goldberg syndrome

Named after R. B. Goldberg and R. J. Shprintzen.

(medicine, medical genetics) A congenital multiple-anomaly syndrome involving craniosynostosis, abdominal hernias, cognitive impairment, and other skeletal malformations.


JWS

JWS (countable and uncountable, plural JWSs)

Jackson-Weiss syndrome
Jackson-Weiss syndrome#English

(pathology, uncountable)Initialism of Jackson-Weiss syndrome.


bipulmonary

Bipulmonary mechanical ventilation for these patients reflects conventional intraoperative ventilation techniques. Initially, patients undergo mechanical ventilation using an oxygen/air mixture with an oxygen inspired fraction (FiO₂) between 0.35 and 0.50.

2013, Giulia Bottazzi, Andrea Gentili, Maria Elena Latrofa, Simonetta Baroncini, “Anesthesia for Thoracic Surgery”, in Mario Lima, editor, Pediatric Thoracic Surgery, Milan: Springer, →DOI, →ISBN, page 51:

(anatomy) Of or pertaining to both lungs.


LSIL

w:low grade squamous intraepithelial lesion

(medicine) Abbreviation of low grade squamous intraepithelial lesion.


HSIL

w:high grade squamous intraepithelial lesion

(medicine) Initialism of high grade squamous intraepithelial lesion.


DMEK

DMEK (countable and uncountable, plural DMEKs)

Descemet membrane endothelial keratoplasty#English

(medicine) Initialism of Descemet membrane endothelial keratoplasty.


DSEK

DSEK (countable and uncountable, plural DSEKs)

Descemet's stripping endothelial keratoplasty#English

(medicine) Initialism of Descemet's stripping endothelial keratoplasty.


DSAEK

DSAEK (countable and uncountable, plural DSAEKs)

Descemet's stripping automated endothelial keratoplasty#English

(medicine) Initialism of Descemet's stripping automated endothelial keratoplasty.


DLEK

DLEK (countable and uncountable, plural DLEKs)

deep lamellar endothelial keratoplasty#English

(medicine) Initialism of deep lamellar endothelial keratoplasty.


DALK

DALK (countable and uncountable, plural DALKs)

deep anterior lamellar keratoplasty#English

(medicine) Initialism of deep anterior lamellar keratoplasty.


plasticosis

(pathology) Fibrosis caused by the ingestion of plastic.


glutition

From Latin gluttītiō, from gluttiō (“to swallow”).

(obsolete, physiology) The act or process of swallowing.


connectopathy

Any initial abnormality in connectivity might also lead to abnormal activity patterns, which could cause further development of abnormal connectivity. Connectopathy would accompany schizophrenia, but it would be difficult to say which is cause and which is effect.

2012, Sebastian Seung, Connectome: How the Brain's Wiring Makes Us Who We Are, page 295:

Recent data have suggested that the atypical visual perception observed in ASD is caused by altered connectivity within parallel visual pathways and attention networks, thereby contributing to the impaired social communication observed in ASD. Therefore, we conclude that the underlying pathophysiological mechanism of ASD constitutes a “connectopathy.”

2017, Takao Yamasaki, Toshihiko Maekawa, Takako Fujita, & Shozo Tobimatsu, "Connectopathy in Autism Spectrum Disorders: A Review of Evidence from Visual Evoked Potentials and Diffusion Magnetic Resonance Imaging", Frontiers in Neuroscience, Volume 11 (link)

If the latter, then schizophrenia was, in neurobiological parlance, a connectopathy— a disease rooted in how cells communicate with one another—and thus not readily discernable in slices or sections of postmortem brain tissue.

2023, Jeffrey A. Lieberman, Malady of the Mind: Schizophrenia and the Path to Prevention, page 128:

(neurology) An atypical presentation or functioning of neural connections within the human brain.


worm-star

From worm + star. From being a star-shape-like collection of worms.

(zoology, pathology) A collection of nematode worms stuck together at their tails, caused by a bacterial infection by Verde1 that causes their tails to become sticky. The condition has a fatality rate of 80% for the worms.


minicolumnopathy

Brain size is therefore not a confound to the reported minicolumnopathy of autistic patients.

2007, Juan Martos Pérez, New Developments in Autism: The Future is Today, page 282:

The initial results suggesting a minicolumnopathy in autism have been reproduced in two independent samples.

2014, Manuel F. Casanova, “The Neuropathology of Autism”, in Fred R. Volkmar, Kevin A. Pelphrey, Rhea Paul, Sally J. Rogers, editors, Handbook of Autism and Pervasive Developmental Disorders, Volume 1: Diagnosis, Development, and Brain Mechanisms, page 518:

The analysis of the current state of research in this area is guided by theoretical concepts developed in our laboratory, namely the neurodevelopmental “minicolumnopathy” hypothesis of autism that predicts an abnormal E/I ratio, GABA deficits, and gamma oscillation abnormality in autism (Casanova et al., 2002, 2003, 2015, 2015).

2020, Estate M. Sokhadze et al., “Psychological Markers of Arousal and Anxiety in Children with Autism Spectrum Disorder”, in Jane Johnson, Stephen M. Edelson, editors, Understanding and Treating Anxiety in Autism: A Multi-Disciplinary Approach, page 39:

(neurology) An atypical presentation of minicolumns within the human brain.


NGU

(medicine) Abbreviation of nongonococcal urethritis.


ARMD

(pathology) Abbreviation of age-related macular degeneration.


PTBD

(medicine) Initialism of percutaneous transhepatic biliary drainage.


PCNL

(urology) Abbreviation of percutaneous nephrolithotomy.


lidoderm

Trade name, from lidocaine and Ancient Greek δέρμα (dérma, “skin”).

What medication can John use to help control his pain? […] He may also benefit from applying a lidoderm to the painful area or using a mild opioid

2007, Yvonne M. D'Arcy, Pain Management: Evidence-Based Tools and Techniques for Nursing Professionals, Marblehead, MA: HCPro, Inc., →ISBN, page 70:

Conditions that result in increased lidocaine absorption and hence increase its blood concentrations include:
• Application of a lidoderm patch for longer than 12 hours/day
• Application of more than three patches at a time

2011, Maggy G. Riad, “Local Anesthetics: Lidocaine transdermal”, in Raymond S. Sinatra, Jonathan S. Jahr, J. Michael Watkins-Pitchford, editors, The Essence of Analgesia and Analgesics, Cambridge: Cambridge University Press, →ISBN, page 290:

(pharmacology) A transdermal patch of lidocaine, used to help reduce pain or itching.


TKR

TKR (countable and uncountable, plural TKRs)

total knee replacement
w:total knee replacement

(surgery) Initialism of total knee replacement.


West Nile encephalitis

(pathology) encephalitis resulting from West Nile fever


AECOPD

chronic obstructive pulmonary disease#English

(medicine) Initialism of acute exacerbation of chronic obstructive pulmonary disease.


twilight anesthesia

(medicine) A form of conscious sedation generally causing anterograde amnesia so the patient is unable to remember the procedure.


conscious sedation

(medicine) An anesthetic technique in which the patient remains awake but undergoes some of the usual effects of sedatives, including pain reduction, anterograde amnesia, etc.


doorknob phenomenon

(medicine) The situation in which a patient waits until the very end of a clinical visit to mention important information.


time-tape

en-verb

time-tape (third-person singular simple present time-tapes, present participle time-taping, simple past and past participle time-taped)

time-tapes (present singular third-person)
time-taping (participle present)
time-taped (participle past)
time-taped (past)

Time-tape the bottle to indicate how much solution should be infused over a given period.

1979, Nancy Meyer Holloway, Nursing the Critically Ill Adult, page 422:

It is helpful to carefully “time-tape" the PN solution bottles (Fig .7).

1983, John A. Kerner, Manual of Pediatric Parenteral Nutrition, page 260:

The bag should be time-taped and checked hourly to ensure accurate infusion of the solution.

1986, Susanna Krey, Rebecca L. Murray, Dynamics of Nutrition Support, page 383:

Whether or not a pump is used, the IV bottle or bag should be time-taped at the time it is hung […]

1987, Marilyn L. Green, Joann Harry, Nutrition in Contemporary Nursing Practice, page 434:

(transitive, medicine, nursing) To attach a tape to (an IV bag) and periodically record the level.


donanemab

(pharmacology) An experimental drug for the treatment of Alzheimer's disease.


morning report

(Canada, US, medicine) A teaching round, based on clinical cases, for medical resident physicians.


phenocopic

(genetics) Of or relating to a phenocopy.


antidrop

(physiology) Preventing or counteracting a drop in body temperature.


antirise

(physiology) Preventing or counteracting a rise in body temperature.


velodorsal

(phonetics, speech pathology) Formed when the soft palate lowers to touch the back of the tongue, due to developmental problems in the anatomy of the mouth, as opposed to velar (or more precisely dorso-velar), where the back of the tongue rises to touch the soft palate.


naphthoylindole

From naphthalene + -yl + indole, because the structure of the drug contains a naphthalene system connected to an indole system by a carbonyl group.

(pharmacology) A class of synthetic psychoactive drugs with cannabinoidergic effects.


chironean

(medicine) Alternative form of chironian.


chironian

(medicine) Chironian ulcer: a particularly intractable form of cutaneous ulcer


surfer's ear

(pathology) An exostosis within the ear canal, caused by irritation from cold wind and water exposure.


MGN

medial geniculate nucleus
medial geniculate nucleus#English

(anatomy) Initialism of medial geniculate nucleus.

membranous glomerulonephritis
membranous glomerulonephritis#English

(medicine) Initialism of membranous glomerulonephritis.


VNTR

We estimated that the following percentage of elements were correctly assembled: 95.4% of alpha satellites; 91.5% of human satellites 2 and 3; 97.7% of segmental duplications (SDs); 94.3% of variable number tandem repeats (VNTRs); 94.2% of short tandem repeats (STRs); and 98.8% of all human repeats²⁶.

2023 May 11, Wen-Wei LiaoMobin AsriJana Ebleret al., “A draft human pangenome reference”, in Nature, volume 617, →DOI, page 313:

variable number tandem repeat
w:variable number tandem repeat

(genetics) Initialism of variable number tandem repeat.


genomicize

genomicize (third-person singular simple present genomicizes, present participle genomicizing, simple past and past participle genomicized)

genomicizes (present singular third-person)
genomicizing (participle present)
genomicized (participle past)
genomicized (past)

We are far from understanding how organisms with small genomes function, let alone how the human genome is organized. As more and more scientific disciplines get “genomicized”, the field will undergo continual transformation, thus a book like this one can only capture a flavor and a moment in time.

2002, Christoph W. Sensen, “Introduction”, in Christoph W. Sensen, editor, Essentials of Genomics and Bioinformatics, Weinheim: Wiley-VCH, →ISBN, page 2:

A plan to ‘genomicize’ epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.

2008 August 7, The American Association for Cancer Research Human Epigenome Task Force, European Union, Network of Excellence, Scientific Advisory Board, “Moving AHEAD with an international human epigenome project”, in Nature, volume 454, →DOI, page 711:

(transitive, genetics) To make genomic; to apply to the field of genomics.


genomicization

From genomicize + -ation or genomic + -ization.

In this book we ask how BOLI, as a partial ‘genomicization’ of the taxonomic discipline, has intensified and scaled up the distribution of practices, between field, lab and database?

2016 [2013], “Introduction”, in Claire Waterton, Rebecca Ellis, Brian Wynne, Barcoding Nature: Shifting Cultures of Taxonomy in an Age of Biodiversity Loss, London: Routledge, →ISBN, page 9:

(genetics) The act or process of genomicizing.


Bidder's organ

(anatomy, zoology) A spherical, brownish organ in most members of the family Bufonidae (true toads), located just in front of the kidney, or mesonephros, and apparently involved in regulating sex hormones.


(medicine) The 2018 revision of the International Classification of Diseases, published by WHO.


tiger stripe

Echocardiography revealed severe eccentric mitral regurgitation with multiple high-intensity signals (tiger stripes) on continuous wave (CW) Doppler. The patient was managed as rheumatic carditis with steroids. Repeat echocardiography after 1 month showed the resolution of tiger stripes.

2022, Najeeb Ullah Sofi, Santosh Kumar Sinha, Mohit Sachan, Ramesh Thakur, “Tiger stripes in carditis of rheumatic origin”, in Heart Views, volume 23, number 4, page 230:

Striated pattern of internal enhancement (tiger stripe sign) relatively specific for nonsuppurative tonsillitis

2023, Dania Tamimi, Specialty Imaging: Temporomandibular Joint and Sleep-Disordered Breathing, page 5569:

(sciences, medicine) A striated pattern on a sensor image that indicates movement or variation in scanned tissue or objects.


MCED

en-noun

MCED (countable and uncountable, plural MCEDs)

Caro is among a pioneering group of people in the US and UK who have elected to take part in a new form of cancer screening known as multi-cancer early detection tests (MCED). […] Critics of MCEDs also warn that a deluge of test results could put additional pressure on already overstretched health services.

2023 May 17, Jamie Smyth, “Quick blood tests to spot cancer: will they help or harm patients?”, in Financial Times:

(medicine) Initialism of multi-cancer early detection.


procline

en-verb

procline (third-person singular simple present proclines, present participle proclining, simple past and past participle proclined)

proclines (present singular third-person)
proclining (participle present)
proclined (participle past)
proclined (past)

Borrowed from Latin prōclīnō (“I bend or lean forward”).

bor+

Coordinate term: retrocline

In Class II cases the maxillary incisors retrocline and the eruption of teeth in the maxillary buccal segments is directed distally during treatment. In the mandibular arch the lower incisors tend to procline and the teeth in the buccal segments erupt in a more mesial direction.

2010, Jayne Harrison, Kathleen O'Donovan, “Orthodontic Dental Nursing”, in Robert S. Ireland, editor, Advanced Dental Nursing, 2nd edition, Chichester: Wiley-Blackwell, →ISBN, page 308:

(intransitive, dentistry) Of teeth, to lean forward.

Coordinate term: retrocline

These curves do have a tendency to procline the incisors so the wires are often tied back (e.g. a wire ligature tied from the molar to a ball hook on the archwire between the lateral incisor and canine) to maintain the arch length and minimise incisor proclination.

2010, Jayne Harrison, Kathleen O'Donovan, “Orthodontic Dental Nursing”, in Robert S. Ireland, editor, Advanced Dental Nursing, 2nd edition, Chichester: Wiley-Blackwell, →ISBN, page 273:

(transitive, dentistry) To cause (teeth) to lean forward.


pyrrolizidine alkaloidosis

(pathology) A disease caused by chronic poisoning from ingesting plants that contain pyrrolizidine alkaloids.


retrocline

en-verb

retrocline (third-person singular simple present retroclines, present participle retroclining, simple past and past participle retroclined)

retroclines (present singular third-person)
retroclining (participle present)
retroclined (participle past)
retroclined (past)

Coordinate term: procline

(intransitive, dentistry) Of teeth, to lean backward.

Coordinate term: procline

These curves do have a tendency to procline the incisors so the wires are often tied back […] to maintain the arch length and minimise incisor proclination. Alternatively, torque can be placed in the archwire to retrocline the incisors.

(transitive, dentistry) To cause (teeth) to lean backward.


IMID

immune-mediated inflammatory disease
w:immune-mediated inflammatory disease

(medicine) Initialism of immune-mediated inflammatory disease.


IMiD

immunomodulatory imide drug
w:immunomodulatory imide drug

(pharmacology) Acronym of immunomodulatory imide drug.


original antigenic sin

(immunology) The propensity of the immune system to preferentially use immunological memory based on a previous infection when a second, slightly different version of the foreign pathogen is encountered, leaving the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections.


Hoskins effect

original antigenic sin
original antigenic sin#English

(immunology) Synonym of original antigenic sin


neurostabilizer

Antiepileptic Drugs / The utility of anticonvulsants in migraine prophylaxis was discovered because both epilepsy and migraine are episodic disorders of the central nervous system that are often comorbid and share certain symptoms. However, when used for migraine prophylaxis, these agents may be more properly described as neurostabilizers.

2005, Andrew Blumenfeld, “Clinical approaches to migraine prophylaxis”, in Am J Manag Care, volume 11, numbers 2 suppl (New Approaches for the Management and Treatment of Migraine), →PMID, retrieved 2023-05-20, page S55-S61:

Recent studies have demonstrated that some neurostabilizers (i.e. antiepileptics) are effective monotherapies for migraine prevention. Topiramate (TPM), a neuromodulatory compound with stabilizing properties, has been demonstrated in several large, randomized, placebo-controlled trials to be an effective and generally well-tolerated migraine preventive therapy and is approved in the UK and many other countries for migraine prevention.

2006, JS BrownG PapadopoulosPJ Neumannet al., “Cost-effectiveness of migraine prevention: the case of topiramate in the UK”, in Cephalalgia, volume 26, number 12, →DOI, →PMID, pages 1473–1482:

Although divalproex and topiramate are anticonvulsants, they are more properly termed neurostabilizers when used for migraine prophylaxis.

2008, Richard G. Wenzel, “Migraine-preventive medications: ensuring their appropriate use”, in J Am Pharm Assoc, volume 48, number 5, →DOI, →PMID, page e107-e120:

(medicine) A substance that helps to stabilize the neural or neurological function of the nervous system; especially, an antiepileptic medication.


pimodivir

With its antiviral drug, pimodivir, J&J aims to help treat influenza patients who have developed resistance to existing antiviral drugs as well as address the lack of approved medications for people hospitalized with the virus, the company said.

2017 June 14, Divya Grover, “Johnson & Johnson's flu drug succeeds in mid-stage trial”, in Reuters:

(pharmacology) An antiviral drug developed as a treatment for influenza.


shibire

Translingual: shi

From Japanese しびれ (shibire, “numbness, paralyzed”). Coined by Japanese-Canadian geneticist and zoologist David Suzuki, its discoverer. Originally discovered in its temperature sensitive form, shibire(ts), which caused the afflicted flies to drop from the sky on a temperature change, appearing to be a gene causing paralysis. Suzuki, referencing his Japanese heritage, chose a Japanese term for being paralyzed as the gene's name.

coin

(genetics) A gene found in Drosophila, its homolog of the dynamin gene.


pseudoconsciousness

LL-Q1860 (eng)-Flame, not lame-pseudoconsciousness.wav

(neuroscience, neurology, psychology, computer science) A state or condition that is not consciousness but seemingly or nearly approaches it or simulates it.


VUR

(medicine) Abbreviation of vesicoureteral reflux.


normosplanchnic

(anatomy) Having or relating to a normal-sized trunk or torso.


microsplanchnic

(anatomy) Having an abnormally small trunk or torso.


macrosplanchnic

(anatomy) Having an abnormally large trunk or torso.


dose dumping

Crushing pills that were designed to be swallowed whole may lead to dose dumping.

(medicine) The uncontrolled rapid release of a drug that was intended to be gradually released into the body.


Thorazine

And if you refuse to get on the bus, they'll take a hypodermic needle and hit you with 100mg of thorazine. Then you won't even realize what's going on until it's too late.

1983 December 10, Mike Riegle, quoting James Sipes, “Sexual Politics of "Crime": Inside and Out”, in Gay Community News, volume 11, number 21, page 5:

(medicine) Brand name for chlorpromazine


fabotherapeutic

(medicine) Of an antivenom: making use of fragment antigen-binding.


fabotherapy

From Spanish faboterápico, coined by Alejandro Alagón Cano from the initial letters of fragment antigen-binding.

(medicine) Treatment involving the use of antivenom developed using fragment antigen-binding.


synchronous diaphragmatic flutter

en-noun

synchronous diaphragmatic flutter (plural synchronous diaphragmatic flutters)

synchronous diaphragmatic flutters (plural)

/ˈsɪŋkɹənəs ˌdaɪəfɹæɡˈmætɪk ˈflʌtə/

(medicine) A rare condition characterised by rhythmic involuntary contractions of the diaphragm and other respiratory muscles innervated by cervical nerve roots.


quinophan

(organic chemistry, pharmacology) Synonym of cinchophen


diiodohydroxyquin

(pharmacology) Synonym of diiodohydroxyquinoline


Malpighian body

Malpighian body (plural Malpighian bodies)


vascular dementia

vascular dementia (countable and uncountable, plural vascular dementias)

He had been diagnosed with vascular dementia, and though the progression of the disease was relatively slow, he had developed tremors and seemed younger and younger as the months knocked on.

2022, Maddie Mortimer, Maps of Our Spectacular Bodies, Picador, page 310:

(medicine) Dementia caused by problems in the blood supply to the brain, resulting from a cerebrovascular disease.


UCx

Coordinate term: BCx

(medicine) Abbreviation of urine culture.


BCx

Coordinate term: UCx

(medicine) Abbreviation of blood culture.


Sengstaken-Blakemore tube

Sengstaken-Blakemore tube (plural Sengstaken-Blakemore tubes)

Named after American neurosurgeon Robert William Sengstaken Sr. (1923–1978) and American vascular surgeon Arthur Blakemore (1897–1970).

Sengstaaken-Blakemore tube (Surg Gynecol Obstet 1976;142:529) with accessory NG tube until endoscopy available if pt hemorrhaging—applying external traction not necessary (GE 1978;75:566); not a substitute nor should it delay endoscopy (Surg Gynecol Obstet 1988;167:331).

2006, “Gastroenterology: Esophageal Varices”, in Steven E. Diaz, The Little Black Book of Emergency Medicine (Jones and Bartlett's Little Black Book Series), 2nd edition, Sudbury, MA: Jones and Bartlett Publishers, →ISBN, page 103:

(medicine) A medical device inserted through the nose or mouth and used occasionally in the management of upper gastrointestinal bleeding due to esophageal varices.


EVEV

Everglades virus
Everglades virus#English

(medicine) Abbreviation of Everglades virus.


SAH

subarachnoid hemorrhage
subarachnoid hemorrhage#English

(medicine) Initialism of subarachnoid hemorrhage.


IVH

intraventricular hemorrhage
w:intraventricular hemorrhage

(medicine) Initialism of intraventricular hemorrhage.


CSDH

Coordinate term: ASDH

Alternative form: cSDH

subdural hematoma
subdural hematoma#English

(medicine) Initialism of chronic subdural hematoma.


cSDH

Coordinate term: aSDH

Alternative form: CSDH


aSDH

Coordinate term: cSDH

Alternative form: ASDH

(medicine) Initialism of acute subdural hematoma.


ASDH

Coordinate term: CSDH

Alternative form: aSDH


papoose board

(medicine) A similar restraint device, adaptable for adults, but used when the patient is lying down rather than being carried.


idioblapsis

(medicine, obsolete) A form of allergy believed not to depend on an antigen-antibody mechanism, but to be accompanied by a quickening of the pulse.


unthriftness

The disease is quite generally distributed and may cause considerable loss and unthriftness among pigs when conditions are favorable for its development.

1957, Arthur Laurence Anderson, Raymond William Gregory, Swine Management: Including Feeding and Breeding, page 499:

Health disorders that are treated with adequate selenium include white muscle muscle disease, retained placenta in cattle, reproductive failure, unthriftness and dead or weak offspring.

The symptoms include wasting as major sign but also unthriftness, paleness of the skin, respiratory distress, diarrhoea and sometimes icterus.

2002, J[oaquim] Segalés, M[ariano] Domingo, “Postweaning multisystemic wasting syndrome (PMWS) in pigs. A review”, in Veterinary Quarterly, volume 24, number 3, →DOI, →ISSN, →OCLC, page 111:

In sub acute and chronic cases, lower doses of aflatoxin produce chronic effects such as lethargy, unthriftness, lameness, hepatitis and delayed death.

2022, Jowel Debnath, Duck Production and Management:

(medicine) The process of wasting away; failure to thrive.


coracoideum

(anatomy) Synonym of coracoid (“small bone linking the scapula and sternum in some vertebrates”)


fluxy

en-adj

fluxy (comparative more fluxy, superlative most fluxy)

more fluxy (comparative)
most fluxy (superlative)

(medicine, archaic) Relating to diarrheal disease.


VLBW

en-noun

VLBW (countable and uncountable, plural VLBWs)

Coordinate term: ELBW

(medicine) Initialism of very low birth weight.


ELBW

ELBW (countable and uncountable, plural ELBWs)

Coordinate term: VLBW

(medicine) Initialism of extremely low birth weight.


pseudotolerance

LL-Q1860 (eng)-Flame, not lame-pseudotolerance.wav

(pharmacology) A patient's requirement for an increased dose of a drug for reasons other than the patient's body having come to tolerate the existing dose.


PPMD

On the other hand, postpartum mood disorder (PPMD) can include the above symptoms, but it doesn't resolve quickly.

2016, Dr. Nancy Lins, Baby Blues: A Naturopathic Approach for Postpartum Health, Balboa Press, →ISBN:

(psychiatry) Initialism of postpartum mood disorder.


aPTT

aPTT (countable and uncountable, plural aPTTs)

Alternative form: APTT

activated partial thromboplastin time
w:activated partial thromboplastin time

(medicine) Initialism of activated partial thromboplastin time.


hyperfibrinemia

Coordinate term: hypofibrinemia

(medicine) An abnormally high level of fibrin (or fibrinogen) in the blood.


menstrual cramp

menstrual cramp (plural menstrual cramps)

A heating pad and gentle stretches are wonderful natural treatments for the pain of menstrual cramps.

2007, Lisa M. Chavis, Ask Your Pharmacist: A Leading Pharmacist Answers Your Most Frequently Asked Questions, St. Martin's Press, →ISBN, page 326:

(medicine) Synonym of period pain; dysmenorrhea.


alloknesis

From allo- + Ancient Greek κνῆσις (knêsis, “itching”).

af

(medicine) Itch sensation in response to a normally non-itch-producing stimulus.


T wave

(medicine, cardiology) A wave on an electrocardiogram that represents the electrical changes generated by the repolarization of the ventricles.


pulse oximetric

pulse oximetric oxygen saturation

(medicine) Of or relating to pulse oximetry.


scrotally

In the past few years, T patches have also been released for prescription usage. Both scrotally applied and nonscrotally applied vehicles are available. These forms of delivery offer more constant T levels and avoid the inconvenience of im injection.

1999, Carrie J. Bagatell, William J. Bremmer, “Androgen and Estrogen Effects on Plasma Lipids in Men”, in Leonard Share, editor, Hormones and the Heart in Health and Disease (Contemporary Endocrinology; 21), Totowa, NJ: Humana Press, →ISBN, page 237:

“Shoot!” came a third exclamation. From me actually. Not only had I collided scrotally with a particular hard and rigid bit of deck furniture but my bucket of precious octopi had just been flipped over and the delicious little darlings were off spinning overboard in furious spumes of spray.

2006, David Yeadon, Seasons on Harris: A Year in Scotland's Outer Hebrides, New York, NY: HarperCollins Publishers, →ISBN, page 103:

(chiefly medicine) With respect to, or via, the scrotum.


i.m.

Alternative forms: IM, I.M., im


PVFS

post-viral fatigue syndrome
post-viral fatigue syndrome#English

(pathology) Initialism of post-viral fatigue syndrome.


Moro reflex

Named after Austrian physician and pediatrician Ernst Moro (1874–1951), who was the first in western medicine to describe the reflex.

named-after

For reasons I shan’t bore you with, I got them to induce me at 39 weeks, at 10am, with the epidural going in first, and it was all a dream. […] But it was all over in time for my daughter to catch the Nigeria v Argentina World Cup game that evening, during which she seemed to reckon everything was miles offside. (Or was that just the Moro reflex?)

2014 December 5, Marina Hyde, “Childbirth is as awful as it is magical, thanks to our postnatal ‘care’”, in The Guardian:

(physiology) A normal primitive reflex elicited by a sudden stimulus, involving abduction and extension of the arms, followed by adduction; it develops between 28 and 32 weeks of gestation and disappears at 3–6 months of age.


gonadodysgenesis

(physiology, rare) Infertility resulting from the degeneration of the gonads (ovaries or testicles) in either sex.


chondroosseous

Calcifications in chondroosseous portion common

2016, B.J. Manaster, “Osteochondroma”, in B.J. Manaster, editor, Diagnostic Imaging: Musculoskeletal: Non-Traumatic Disease, 2nd edition, Philadelphia, PA: Elsevier, →ISBN, page 250:

(anatomy) Relating to or composed of cartilage and bone.


undertubulation

Lesion may be sessile (broad-based), mimicking undertubulation of metaphysis

(medicine) Insufficient tubulation of long bones, resulting in diaphyseal or metaphyseal widening.


BPE

en-noun

BPE (countable and uncountable, plural BPEs)

(medicine) Initialism of benign prostatic hyperplasia.


VDH

If a physician believed that an underlying organic pathology existed, cases were diagnosed as valvular disease of the heart (VDH), although death certificates have shown that in reality most of these cases were functional.

2005, Edgar Jones, Simon Wessely, Shell Shock to PTSD, page 120:

(medicine) Initialism of valvular disease of the heart.


DFSP

dermatofibrosarcoma protuberans
dermatofibrosarcoma protuberans#English

(oncology) Abbreviation of dermatofibrosarcoma protuberans.


ICAS

(medicine) Initialism of isolated congenital asplenia.


pharyngeal arch

pharyngeal arch (plural pharyngeal arches)

(zoology, anatomy, embryology) Any of a series of structures seen in the embryo of vertebrates that are precursors for many structures, notably the jaws and (in fish) the branchial arches.

arc pharyngé

embryonic precursor to any of several structures


Necatorina

carbon tetrachloride
carbon tetrachloride

(tradename, medicine) Tradename of a carbon tetrachloride-based anthelmintic medication.


island dressing

island dressing (plural island dressings)

(medicine) A kind of adhesive bandage for wounds having light to moderate exudate.


underobturation

(dentistry) Insufficient obturation; an imperfect stopping up, or underfilling.


overobturation

(dentistry) Excessive obturation; overfilling.


backprime

en-verb

backprime (third-person singular simple present backprimes, present participle backpriming, simple past and past participle backprimed)

backprimes (present singular third-person)
backpriming (participle present)
backprimed (participle past)
backprimed (past)

From back + prime (“to prepare a mechanism for its main work; to apply a coat of primer paint to”).

af

Hang and adjust the rate or set the infusion pump as indicated. If using an infusion pump, follow the specific manufacturer's guidelines to backprime the secondary set.

2010, Linda Laskowski-Jones, Alexandra Falkowski, “Infusion Therapy”, in Donna D. Ignatavicius, M. Linda Workman, editors, Medical-Surgical Nursing: Patient-Centered Collaborative Care, 6th edition, St. Louis, MO: Saunders, →ISBN, page 220:

(transitive, medicine) To add (a secondary infusion) to a patient by priming it with fluid from the primary infusion.


dorsoumbonal

(anatomy) Relating to the back and umbo.


extramusculoskeletal

(anatomy) Situated outside of the musculoskeletal system.


mid cell

From mid (“middle”) + cell, named after the fact that the cell appears as part of the middle peak of three peaks usually seen in a white blood cell histogram organized by cell volume and analyzed in three parts.

(hematology, chiefly in the plural) A white blood cell, such as a monocyte or blast cell, with around 100 femtoliters in volume, greater than most lymphocytes and less than most granulocytes.


summit disease

en-noun

summit disease (countable and uncountable, plural summit diseases)

From summit + disease, from the tendency of infected insects to climb to the upper parts of plants before dying.

Some fungus mediated behavioral changes have been recorded, such as "summit disease" where infected grasshoppers climb to the top of plants to die[…]. This may aid spore dispersal, but it has also been suggested that it is a mechanism by which the host reduces infection through increased exposure to UV.

2010, M[ark] S[tanislaw] Goettel, J[ørgen] Eilenberg, T[ravis] Glare, “Entomopathogenic Fungi and Their Role in Regulation of Insect Populations”, in Lawrence I[rwin] Gilbert, Sarjeet S[ingh] Gill, editors, Insect Control: Biological and Synthetic Agents, London; Burlington, Mass.: Academic Press, →ISBN, page 405:

Soybean looper, Thysanoplusia orichalcea, infected with Thysanoplusia orichalcea nucleopolyhedrovirus. The image illustrates what is known as treetop disease or summit disease, whereby the host climbs to an exposed position (e.g., on vegetation) before death to facilitate dispersal of the pathogen.

2012, David I[an] Shapiro-Ilan, Denny J[oseph] Bruck, Lawrence A[nthony] Lacey, “Principles of Epizootiology and Microbial Control”, in Fernando E. Vega, Harry K[azuyoshi] Kaya, editors, Insect Pathology, 2nd edition, London; Waltham, Mass.: Academic Press, →ISBN, figure 3.2 caption, page 38, column 2:

Many foliar-feeding hosts infected with bacterial and viral pathogens display classic "summit" diseases, in which the infected insects move up the foliage immediately before they die. This behavioral host response to infection results in increased transmission to uninfected hosts, as the pathogen propagules from the cadaver shower down on the foliage below, resulting in increased transmission to the rest of the population.

2014, D[enny] J[oseph] Bruck, “Entomopathogens as Insect Biocontrol Agents”, in Robert G[rant] Linderman, D[avid] Michael Benson, editors, Compendium of Rhododendron and Azalea Diseases and Pests, 2nd edition, St. Paul, Minn.: APS Press, →ISBN, page 84, column 2:

A particularly striking example of host manipulation called ‘summit disease’ occurs across a wide range of insect groups including aphids, grasshoppers, butterflies and moths, beetles and ants. The fungus grows within the host’s body, infecting various organs, but before it reaches a point when the animal can no longer move, somehow the fungus causes the host to climb to a higher point like the top of a grass stem or tree and wait there to die. This can be beneficial to the fungus as from this elevated position they can spread their spores far and wide on the breeze.

2017, Jack Ashby, “Caterpillar with Parasitoid Fungus: Dried Specimen”, in Animal Kingdom: A Natural History in 100 Objects, Stroud, Gloucestershire: The History Press, →ISBN:

In the case of Ophiocordyceps, an infected ant's behaviour can be thought of as fungal behaviour. The death grip, summit disease, these are extended characteristics of the fungus, part of its extended phenotype.

2020, Merlin Sheldrake, “Mycelial Minds”, in Entangled Life: How Fungi Make Our Worlds, Change Our Minds, and Shape Our Futures, London: The Bodley Head, →ISBN, page 124:

(phytopathology) A disease (usually fungal, caused by the species complex Entomophaga grylli) that affects various species of insect, especially grasshoppers, whereby the infected individual typically climbs to the upper parts of a plant, attaches itself there and dies, at which point the infecting agent disperses itself, usually in the form of spores.

Gipfelkrankheit

disease that affects various species of insect


puberphonia

puberphonia (countable and uncountable, plural puberphonias)

(pathology) A functional voice disorder that is characterized by the habitual use of a high-pitched voice after puberty.


spondylic

(anatomy) Relating to a spondyle or vertebra.


lenticular nucleus

lenticular nucleus (plural lenticular nuclei or lenticular nucleuses)

lenticular nuclei (plural)
lenticular nucleuses (plural)

(neuroanatomy) Either one of two parts —one on each hemisphere— of the basal ganglia, which is roughly lens-shaped and having two parts which would correspond to two sides of a biconvex lens: the putamen and the globus pallidus (which face outboard and inboard, as it were, respectively).


lentiform nucleus

lentiform nucleus (plural lentiform nuclei or lentiform nucleuses)

lentiform nuclei (plural)
lentiform nucleuses (plural)


ventral striatum

ventral striatum (plural ventral striatums or ventral striata)

ventral striatums (plural)
ventral striata (plural)

(neuroanatomy) The forward part of the corpus striatum, made up of four separate parts, two per hemisphere: the nucleus accumbens and the olfactory tubercle.


dorsal striatum

dorsal striatum (plural dorsal striatums)

(neuroanatomy) The backward part of the corpus striatum. It consists (in each hemisphere) of the lenticular nucleus and the caudate nucleus; these are adjacent to each other (at one end of the latter, with the rest of the latter also curving around the former).


hydrocyanicum

(obsolete, medicine) hydrocyanic acid, prussic acid, a colorless liquid obtained from amygdalin, present in bitter almonds, peach stones, plums and laurel leaves


superlingua

(anatomy) Either of a pair of lateral lobes borne on the hypopharynx of apterygotes, earwigs, and nymphal mayflies.


interthalamic adhesion

interthalamic adhesion (plural interthalamic adhesions)

(neuroanatomy) A sort of bridge connecting the pair of thalami. It is quite short since the thalami are quite close to each other (and to the median plane between them).


minimum inhibitory concentration

minimum inhibitory concentration (plural minimum inhibitory concentrations)

minimum inhibitory concentrations (plural)

(microbiology, pharmacology) The lowest concentration of a chemical (usually a drug) which prevents visible in vitro growth of bacteria or fungi.


pasotuxizumab

From [Term?] + -tu- (“tumor”) + -xi- (“chimeric”) + -zumab (“humanized monoclonal antibody”).

af

Pasotuxizumab (AMG 212) is a canonical BiTE antibody targeting PSMA [77]. The anti-tumor activity which was defined by PSA level decrease was dose-dependent. Two patients achieved long-term PSA responses with more than 1 year of treatment at doses of 40 μg/d and 80 μg/d, respectively.

2021 May 26, Shujie Zhou, Mingguo Liu, Fei Ren, Xiangjiao Meng, Jinming Yu, “The landscape of bispecific T cell engager in cancer treatment”, in Biomarker Research, volume 9, →DOI, article 38, page 4:

(pharmacology) A bi-specific T-cell engager monoclonal antibody developed for the treatment of prostate cancer.


MTD

en-noun

MTD (countable and uncountable, plural MTDs)

Among 10 patients in the maximum tolerated dose (MTD) cohort at the dose of 400 μg/d, the overall response rate (ORR) was 70% with 5 MRD-negative CR, 1 very good partial response (VGPR), and 1 PR.

maximum tolerated dose
w:maximum tolerated dose

(pharmacology) Initialism of maximum tolerated dose.


MRD

MRD (countable and uncountable, plural MRDs)

minimal residual disease
w:minimal residual disease

(oncology) Initialism of minimal residual disease.


LVEDP

LVEDP (countable and uncountable, plural LVEDPs)

Coordinate term: LVESP

(physiology) Initialism of left ventricular end-diastolic pressure.


LVESP

LVESP (countable and uncountable, plural LVESPs)

Coordinate term: LVEDP

(physiology) Initialism of left ventricular end-systolic pressure.


bloodless surgery

bloodless surgery (countable and uncountable, plural bloodless surgeries)

(medicine) Surgery performed without transfusion of allogeneic blood.


LoE

Alternative form: LOE

(medicine) Initialism of level of evidence.


MACE

major adverse cardiovascular event
w:major adverse cardiovascular event

(medicine) Initialism of major adverse cardiovascular event.


JAKi

(pharmacology) Initialism of Janus kinase inhibitor.


JAKinib

From JAK (“Janus kinase”) + -in- + -ib (“small molecule inhibitor”).

af

Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. […] The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.

2019 July 8, Michael BonelliKarolina DalwigkAlexander PlatzerIsabel Olmos CalvoSilvia HayerBirgit Niederreiteret al., “IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes”, in Experimental & Molecular Medicine, volume 51, →DOI, page 1:

(pharmacology) A Janus kinase inhibitor.


filgotinib

Both upadacitinib and filgotinib have been referred to as “second-generation jakinibs” since they both preferentially inhibit JAK1 in vitro but their clinical efficacy and safety, to a large extent, is similar to pan-jakinibs in RA, although anemia and herpes zoster are seen less often with filgotinib.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2168:

rheumatoid arthritis
rheumatoid arthritis

(pharmacology) A medication, belonging to the class of Janus kinase inhibitors, used for the treatment of rheumatoid arthritis.


LDSC

w:linkage disequilibrium score regression

(genetics) Initialism of linkage disequilibrium score regression.


eQTL

expression quantitative trait locus
w:expression quantitative trait locus

(genetics) Initialism of expression quantitative trait locus.


CARPA

(medicine) Acronym of complement activation-related pseudoallergy.


MBV

en-noun

MBV (countable and uncountable, plural MBVs)

(medicine) Initialism of myocardial blood volume.

(medicine) Abbreviation of microvascular blood volume.


BHC

BHC (countable and uncountable, plural BHCs)

behavioral health consultant
behavioral health consultant#English

(medicine, countable) Initialism of behavioral health consultant.


hypophalangia

From hypo- + -phalangia (“a condition of the phalange bones”).

af

(medicine) The congenital absence of one or more of the phalanges ("one of the bones of the finger or toe") in one's hand.


-phalangia

From Latin phalanx, with combining form phalang-.

a- + -phalangia → aphalangia

brachy- + -phalangia → brachyphalangia

(medicine) Denoting a condition of the phalange bones in the fingers and toes.


RDT

rapid diagnostic test
w:rapid diagnostic test

(medicine) Initialism of rapid diagnostic test.


VTM

viral transport medium
w:viral transport medium

(medicine) Initialism of viral transport medium.


PAD

peripheral artery disease
w:peripheral artery disease

(pathology) Initialism of peripheral artery disease.


upadacitinib

Upadacitinib monotherapy has also been shown to be more effective than MTX in MTX-naive patients with RA (24). Both upadacitinib and filgotinib have been referred to as “second-generation jakinibs” since they both preferentially inhibit JAK1 in vitro but their clinical efficacy and safety, to a large extent, is similar to pan-jakinibs in RA, […]

ankylosing spondylitis
ankylosing spondylitis

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several immune-mediated diseases such as rheumatoid arthritis, ankylosing spondylitis, and atopic dermatitis.


peficitinib

Peficitinib, a pan-JAK inhibitor, is approved in Japan, Republic of Korea, and Taiwan for the treatment of RA in patients with an incomplete response to csDMARDs (19, 20). Tofacitinib, baricitinib, and peficitinib have shown clinical, functional, and radiographic efficacy, after failure of a csDMARD, prior to treatment with a bDMARD, or after treatment with a bDMARD.

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of rheumatoid arthritis.


decernotinib

Developed to target the kinase domain of JAK3, decernotinib (VX-509) showed selective in vitro inhibition of JAK3 over the other JAKs and efficacy in RA (73, 74). However, a CYP3A4-mediated drug–drug interaction was also described, potentially limiting the use of decernotinib; development of this molecule has currently been halted (75).

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2172:

(pharmacology) An experimental medication belonging to the class of Janus kinase inhibitors.


brepocitinib

PF-06826647 is a TYK2-selective jakinib (68) currently in trials for the treatment of psoriasis, UC, and hidradenitis suppurativa; brepocitinib is a TYK2/JAK1 inhibitor that was assessed in a phase II trial of psoriasis where clinical responses were seen with all doses (69).


itacitinib

The JAK1-selective inhibitor, itacitinib, is currently being assessed in multiple clinical trials for oncologic indications as well as for chronic and acute GVHD, including GVHD prophylaxis.


ritlecitinib

Ritlecitinib is an irreversible covalent inhibitor that binds to a distinct cysteine residue in the JAK3 catalytic domain, which other JAK family members lack. […] Ritlecitinib was found to be superior to placebo in a phase II study in RA patients with an inadequate response to MTX (76).

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2173:

(pharmacology) A medication belonging to the class of Tec/Janus kinase inhibitors, used for the treatment of alopecia areata.


fedratinib

Fedratinib is a selective JAK2 inhibitor approved for primary and secondary myelofibrosis. An important AE observed with fedratinib is Wernicke’s encephalopathy, which has been observed in patients taking the highest daily dosage (500 mg) (70).

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of myeloproliferative diseases including myelofibrosis.


delgocitinib

Delgocitinib (JTE-052) is a topical jakinib approved in Japan for atopic dermatitis and oclacitinib, a JAK1/JAK2/JAK3 inhibitor, is approved for canine allergic dermatitis.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2170:

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of atopic dermatitis.


cerdulatinib

Another JAK/Syk inhibitor, cerdulatinib (PRT062070), has been tested in several trials for the treatment of leukemia and lymphoma, and a topical formulation is being tested in phase II trials in patients with vitiligo.

(pharmacology) A medication belonging to the class of Syk/Janus kinase inhibitors, being developed for treatment of hematological malignancies.


gusacitinib

Gusacitinib (ASN002) is an oral JAK/Syk inhibitor that showed clinical efficacy, associated with decreased expression of inflammatory biomarkers, in a phase II trial in atopic dermatitis (77).

(pharmacology) An experimental medication belonging to the class of Syk/Janus kinase inhibitors.


gandotinib

Gandotinib is a JAK2-selective inhibitor that has potential increased potency for the JAK2^(V617F) mutant kinase and has shown efficacy in myeloproliferative neoplasm (72), although there are currently no ongoing clinical investigations of gandotinib.


disease-modifying

Coordinate term: symptomatic

disease-modifying drug

(medicine) Of a treatment, that reduces the progression and activity of a disease by altering its underlying pathophysiological processes.


DMOAD

(pharmacology) Initialism of disease-modifying osteoarthritis drug.


pseudotolerant

en-adj

pseudotolerant (comparative more pseudotolerant, superlative most pseudotolerant)

more pseudotolerant (comparative)
most pseudotolerant (superlative)

LL-Q1860 (eng)-Flame, not lame-pseudotolerant.wav

(pharmacology) Requiring an increased dose of a drug for reasons other than one's body having come to tolerate the existing dose.


MHV

(medicine) Initialism of mechanical heart valve.


CIED

(medicine) Initialism of cardiac implantable electronic device.


LMWH

en-noun

LMWH (countable and uncountable, plural LMWHs)

Coordinate term: UFH

low-molecular-weight heparin
w:low-molecular-weight heparin

(pharmacology) Initialism of low-molecular-weight heparin.


LVEF

LVEF (countable and uncountable, plural LVEFs)

ejection fraction
ejection fraction#English

(medicine) Initialism of left ventricular ejection fraction.


UFH

Coordinate term: LMWH

(pharmacology) Initialism of unfractionated heparin.


LVESD

LVESD (countable and uncountable, plural LVESDs)

Coordinate term: LVEDD

(medicine) Initialism of left ventricular end-systolic diameter.


LVEDD

LVEDD (countable and uncountable, plural LVEDDs)

Coordinate term: LVESD

(medicine) Initialism of left ventricular end-diastolic diameter.


andexanet

(pharmacology) Synonym of andexanet alfa.


IHD

IHD (countable and uncountable, plural IHDs)

ischemic heart disease
ischemic heart disease#English

(pathology) Initialism of ischemic heart disease.


beta blockade

beta blockade (usually uncountable, plural beta blockades)

(pharmacology) The action of a beta blocker.


ALSer

One seldom sees words like “deadbeat” or “lazy” used in the same sentence with ALS. In fact, one of the only traits ALSers seem to share is an energetic past. In almost every case, victims are either classic over-achievers or chronic workaholics.

1993, Dennis Kaye, “The Big Lie”, in Laugh, I Thought I'd Die: My Life With ALS, Toronto: Viking, →ISBN, page 39:

amyotrophic lateral sclerosis
amyotrophic lateral sclerosis

(informal, medicine) A person with amyotrophic lateral sclerosis (ALS).


cryptorheic

From English crypto- (prefix meaning ‘hidden’) + Ancient Greek ῥέω (rhéō, “to flow, gush, stream”) + -ic (suffix meaning ‘of or pertaining’ to forming adjectives).

af

(medicine, obsolete) Pertaining to an unspecified or unidentified discharge or secretion.


non-24-hour sleep-wake disorder
non-24-hour sleep-wake disorder#English

(pathology) Abbreviation of non-24-hour sleep-wake disorder.


uterine horn

(anatomy) a point in the upper uterus where the fallopian tubes exit to meet the ovaries. They are one of the points of attachment for the round ligament of uterus (the other being the mons pubis)


thalassemiac

To further assess whether a specific genotype or group of TTV is associated with elevated ALT levels in thalassemiacs, we compared the genotypes infecting patients with abnormal ALT levels (>100 IU/L) and patients with normal ALT levels (<50 IU/L).

2008 February, Yu-Wen Hu, Moslih I. Al-Moslih, Mahmoud Talib Al Ali, Samra Uzicanin, Heather Perkins, Qi-Long Yi, Shabnam Rahimi Khameneh, Jun Wu, Earl G. Brown, “Clinical Outcome of Frequent Exposure to Torque Teno Virus (TTV) Through Blood Transfusion in Thalassemia Patients With or Without Hepatitis C Virus (HCV) Infection”, in Journal of Medical Virology, volume 80, number 2, →DOI, page 369:

(medicine) A person who has thalassemia.


Colles' fracture

en-noun

Colles' fracture (plural Colles' fractures)

Named after Irish surgeon Abraham Colles (1773–1843), who first described it in 1814.

named-after

(medicine) A distal fracture of the radius causing a dorsal displacement of the distal fragment, typically occurring as a result of a fall on an outstretched hand.


hemidystrophy

(medicine) Dystrophy of one side of the body.


Hansenosis

From Hansen + -osis; see Hansen's disease.


organ of elimination

en-noun

organ of elimination (plural organs of elimination)

The delicate surface of the lungs, and, indeed, of the whole air passages, is […] also a great organ of elimination. Camphor, phosphorus, ether, diluted alcohol, gases, and various odorous substances, when introduced into the system, escape in a great measure by the lungs: whence they are perceived in the breath[…]

Thus in my opinion the question is decided ; the kidney is but an organ of elimination; its office in diabetes is to eliminate the sugar from the blood, as it is in health to eliminate the urea.

1841, Changes of the blood in disease, page 21:

[…]that most important organ of elimination the skin, in the glow of which, and in its cleansed pores, and promoted transpiration, an increased exhalation and excretion are obtained, through which in the course of weeks any degree of purification of the blood that may be supposed necessary, may be arrived at.

1846, Observations on hydropathy; with an account of the principal cold water establishments of Germany, page 43:

For man and animals the liver receives the food for the body: the liver is the principal organ of elimination; the liver appears to play the role of cytoplasm; it appears to be the negative pole of the organism, playing always with the positive pole—the brain.

1926, The Therapeutic Gazette, page 168:

(anatomy) Any bodily organ that produces or excretes waste products.


infantilistic

en-adj

infantilistic (comparative more infantilistic, superlative most infantilistic)

more infantilistic (comparative)
most infantilistic (superlative)

(pathology) Exhibiting or relating to infantilism.


postmedia

Coordinate term: premedia


premedia

Coordinate term: postmedia


severe combined immunodeficiency

en-noun

severe combined immunodeficiency (uncountable)

(pathology) A genetic disorder characterized by the disturbed development of functional T cells and B cells, resulting in extreme vulnerability to infectious diseases.


intermetatarseum

(anatomy) A rare sesamoid bone situated in the foot found in 4% of the human population.


vesalianum

(anatomy) A rare sesamoid bone situated in the foot found in less than 1% of the human population.


BPSD

(medicine) Initialism of behavioral and psychological symptoms of dementia.


FUO

FUO (countable and uncountable, plural FUOs)

(pathology) Initialism of fever of unknown origin.


vivax malaria

(medicine) Malaria caused by the parasite Plasmodium vivax.


falciparum malaria

Plasmodium falciparum
Plasmodium falciparum#Translingual

(medicine) malaria caused by the parasite Plasmodium falciparum.


knowlesi malaria

(medicine) Malaria caused by the parasite Plasmodium knowlesi.


inverse agonist

inverse agonist (plural inverse agonists)

(pharmacology) A drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist.


congenital heart disease

congenital heart disease (countable and uncountable, plural congenital heart diseases)

Advances in surgical treatment of congenital heart disease have contributed to the need of more accurate techniques for evaluating alterations in physiology of the circulation.

1951 March, J. H. Lehmann, A. D. Johnson, W. C. Bridges, J. Michel, D. M. Green, “Cardiac Catheterization—A Diagnostic Aid in Congenital Heart Disease”, in Northwest Medicine, volume 50, number 3, Portland, Ore.: Northwest Medical Publishing Association, page 170:

congenital heart defect
congenital heart defect#English

(pathology, cardiology) Synonym of congenital heart defect.


Fick principle

Named after German physician and physiologist Adolf Eugen Fick (1829–1901).

named-after

The rate of blood flow in the peripheral and pulmonic vessels and the approximate size of existing shunts can be calculated by application of the Fick principle. […] It may be of interest to explain in some detail the Fick principle as employed in calculation of cardiac output, pulmonic blood flow and blood flow in shunts.

1951 March, J. H. Lehmann, A. D. Johnson, W. C. Bridges, J. Michel, D. M. Green, “Cardiac Catheterization—A Diagnostic Aid in Congenital Heart Disease”, in Northwest Medicine, volume 50, number 3, Portland, Ore.: Northwest Medical Publishing Association, page 171:

(physiology) A principle used in physiology and medicine, originally applied to measure cardiac output, stating that the total uptake (or release) of a substance by an organ is equal to the product of the blood flow through the organ and the arteriovenous concentration difference of the substance.


vestibulourethral

(anatomy) Relating to the vulval vestibule and the urethra.


Sims position

Named after American physician J. Marion Sims (1813–1883).

The conventional positions now generally in use in obstetrics are the modified lithotomy position, with the patient on her back, and to a lesser extent the Sims position, wherein the patient reclines on her side, the upper knee being drawn up on the abdomen.

1951 February, Forrest H. Howard, “The Physiologic Position for Delivery”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 98:

(medicine) A medical position in which the patient lies on the left side with the right hip and knees bent and the left hip and lower extremity straight, often used for rectal and vaginal examination.


midforceps

Those who are using block anaesthesia are familiar with the fact that the mother has lost the expulsive urge, midforceps are not unusual and outlet forceps are almost routine with a block.

1951 February, Forrest H. Howard, “The Physiologic Position for Delivery”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 99:

(medicine, also attributively) An obstetrical method for delivery of a baby using a forceps when the head is already engaged and the station is above +2 cm (or, formerly, when the head is already engaged but the criteria for low forceps are not met).


midpelvis

At the midpelvis, transverse narrowing may result either from convergent sidewalls or prominent spines or both.

1963 May 1, David N. Danforth, Averon H. Ellis, “Midforceps delivery—a vanishing art?”, in American Journal of Obstetrics and Gynecology, volume 86, number 1, →DOI, page 32:

(anatomy) A pelvic plane defined by the ischial spines, the lower edge of the pubic symphysis, and the boundary of the fourth and fifth sacral vertebra.


borofax

A proper dressing contributes immensely to the comfort of the patient, as well as to a satisfactory cosmetic result. After the wound is properly sutured, vaseline or borofax is lightly applied along the suture line.

1951 February, Charles E. Gurney, Verner V. Lindgren, “Early Care of Traumatic Wounds of the Face”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 93:

(pharmacology) An ointment containing boric acid, applied to the skin as an antiseptic.


triple-negative breast cancer

en-noun

triple-negative breast cancer (countable and uncountable, plural triple-negative breast cancers)

(pathology) A type of breast cancer which is lacking in receptors for both estrogen (ER) and progesterone (PR), and for which HER-2 is not a significant feature.


peritoneoscopy

peritoneoscopy (countable and uncountable, plural peritoneoscopies)

Decker had just introduced his culdoscope and was advocating culdoscopy. I actually saw two peritoneoscopies during training but it had not achieved wide use.

1951 July, Richard D. Reekie, “Critical Analysis of Recent Advances in Gynecology”, in Northwest Medicine, volume 50, number 7, Portland, Ore.: Northwest Medical Publishing Association, page 508:

(medicine, dated) Examination of the abdominal cavity using a narrow instrument inserted through a small incision in the peritoneum.


neoprontosil

In the field of therapeutic aids, chemotherapy and antibiotics have been completely developed since that time. We had prontosil and neoprontosil and thought we were very fortunate.

(pharmacology) A soluble form of prontosil.


peritoneoscope

The same thing may be said about the peritoneoscope. Peritoneoscopy for pelvic lesions has some value and yet its risks are rather great in the patients that have enough pelvic pathology to indicate its use, just as in the use of the culdoscope.

1951 July, Richard D. Reekie, “Critical Analysis of Recent Advances in Gynecology”, in Northwest Medicine, volume 50, number 7, Portland, Ore.: Northwest Medical Publishing Association, page 511:

(medicine, dated) A narrow medical instrument used in peritoneoscopy.


antehelix

antehelix (plural antehelices or antehelixes)

antehelices (plural)
antehelixes (plural)

(anatomy) Alternative spelling of antihelix.


lateral canthus

lateral canthus (plural lateral canthi or lateral canthuses)

lateral canthi (plural)
lateral canthuses (plural)

Coordinate term: medial canthus

She was working on Wúràọlá’s eyes, tracing a line towards her lateral canthus.

2023, Ayọ̀bámi Adébáyọ̀, A Spell of Good Things, Canongate Books, page 293:


medial canthus

medial canthus (plural medial canthi or medial canthuses)

medial canthi (plural)
medial canthuses (plural)

Coordinate term: lateral canthus


grape therapy

(medicine) The therapeutic use of grapes.


SASP

SASP (countable and uncountable, plural SASPs)

(pharmacology) Abbreviation of salazosulfapyridine.


Hereford disease

(veterinary medicine) Synonym of grass tetany


grass tetany

(veterinary medicine) A metabolic disease of ruminants, involving magnesium deficiency, and usually occurring after grazing on pastures of rapidly growing grass.


HHD

HHD (countable and uncountable, plural HHDs)

(medicine) Initialism of home hemodialysis.

hiatus hernia diafragmatica
hiatus hernia diafragmatica#English

(medicine) Initialism of hiatus hernia diafragmatica.


misstage

en-verb

misstage (third-person singular simple present misstages, present participle misstaging, simple past and past participle misstaged)

misstages (present singular third-person)
misstaging (participle present)
misstaged (participle past)
misstaged (past)

In the tumors that were misstaged, most errors occurred between stages T2 (overstaging) and T3 (understaging); in terms of therapeutic considerations, this distinction is more critical than that between stages T1 and T2.

1998, Morton A. Meyers, Neoplasms of the Digestive Tract, page 407:

To do the work chapter, reproducible staging of chick embryos is required. When misstaging it will be impossible to repeat a given experiment.

2008, Rocky S. Tuan, Cecilia W. Lo, Developmental Biology Protocols: Volume III, page 244:

Despite this, CT urogram has been shown to misstage nearly 40% of patients.

2014, Philip M Hanno, Thomas J. Guzzo, S. Bruce Malkowicz, Penn Clinical Manual of Urology, page 563:

When Imazu et al. compared conventional EUS and contrast-enhanced harmonic EUS in terms of preoperative T-staging of pancreatobiliary tumors, they found that contrast-enhanced harmonic EUS correctly T-staged 24 of 26 pancreatobiliary tumors, six of which were misstaged by conventional EUS.

2015, Mihir S. Wagh, Peter V. Draganov, Pancreatic Masses: Advances in Diagnosis and Therapy, page 134:

(medicine, biology) To assess incorrectly as belonging to a different stage than is actually the case


oncovaccine

In a review study published in January 2009, the following suggestions were offered for the successful development of an oncovaccine: Aim for contexts with a manageable level of sickness.

2022, Fouad Sabry, Virotherapy: A virus to find and destroy cancer cells, page 84:


nervo-bilious

en-adj

nervo-bilious (comparative more nervo-bilious, superlative most nervo-bilious)

more nervo-bilious (comparative)
most nervo-bilious (superlative)

Patients to whom chamomilla is suitable are of a sensitive, irritable disposition, and do not bear pain with stoical indifference. They belong either to the purely nervous or the nervo-bilious temperament.

1876, E[dward] B[arton] Shuldham, Headaches: Their Causes and Treatment, second edition, London: E. Gould & Son, page 51:

(phrenology, obsolete) Easily excitable and with energy and strength of mind and body.


ureteroproctostomy

en-noun

ureteroproctostomy (countable and uncountable, plural ureteroproctostomies)

The ureteral catheters are passed through the holes and down toward the anus. Mucosa-to-mucosa ureteroproctostomies are made over the catheters with atraumatic chromic catgut. The catheters insure patency, prevent reflux, and temporarily divert urine from the suture line.

1954 February 15, Oswald S. Lowsley, Thomas H. Johnson, Antonio E. Rueda, “Operation for Urinary Diversion”, in Modern Medicine, volume 22, number 4, Minneapolis, Minn.: Modern Medicine Publications, Inc., page 89:

(medicine) A form of urinary diversion involving the creation of an anastomosis between a ureter and the rectum.


sulfathalidine

The bowel is prepared preoperatively with neomycin and sulfathalidine. A wide transverse lower abdominal incision is used.

(pharmacology, dated) Synonym of phthalylsulfathiazole.