-conazole

(pharmacology) Used to form names of miconazole derivatives used as systemic antifungal agents.


-relin

(pharmacology) Used to form names of pituitary hormone-release stimulating peptides, especially of LHRH release–stimulating peptides.


-morelin

/məʊˈɹɛl.ɪn/

From [Term?] + -relin (“pituitary hormone release–stimulating peptide”).

af

(pharmacology) Used to form names of growth hormone release–stimulating peptides.


-tirelin

From thy(rotropin) + -relin (“pituitary hormone release–stimulating peptide”).

thyrotropin-releasing hormone
w:thyrotropin-releasing hormone

(pharmacology) Used to form names of thyrotropin-releasing hormone analogs.

-morelin

growth hormone release–stimulating peptide


estr-

oestr- (alternative)
-estr- (alternative)

(pharmacology) Used to form names of estrogens.


-ifene

(pharmacology) Used to form names of clomifene or tamoxifen derivatives used as antiestrogens or estrogen receptor modulators.


-mifene

(pharmacology) Used to form names of clomifene derivatives used as antiestrogens or estrogen receptor modulators.


-oxifene

(pharmacology) Used to form names of tamoxifen derivatives used as antiestrogens or estrogen receptor modulators.


Premarin

(trademark, pharmacology) A trademark for a mixture of estrogenic compounds obtained from the urine of pregnant mares and used chiefly for estrogen replacement therapy.


-mestane

(pharmacology) Used to form names of aromatase inhibitors.


-rozole

(pharmacology) Used to form names of imidazole-triazole derivatives used as aromatase inhibitors.


gest-

-gest- (alternative)
-gest (alternative)

(pharmacology) Used to form names of steroids, progestogens.


-gest

gest- (alternative)
-gest- (alternative)


mito-

# From Ancient Greek μίτος (mítos, “thread of the warp”).
# From mitosis.

der

(pharmacology) Used to form names of nucleotoxic agents used as antineoplastics.


insulin lispro

(pharmacology) A short-acting insulin analogue administered by injection in the treatment of type 1 and type 2 diabetes. Trade names include Humalog among others.


insulin aspart

(pharmacology) A short-acting modified recombinant form of insulin (a short-acting insulin analogue) administered by subcutaneous injection in the treatment of type 1 and type 2 diabetes. Trade names (trademarks) include NovoLog, Fiasp, and others.


insulin glulisine

(pharmacology) A rapid-acting insulin analogue.


insulin glargine

(pharmacology) A long-acting recombinant form of insulin (trademark Lantus) administered by subcutaneous injection for the management of type 1 and type 2 diabetes.


insulin detemir

From insulin + de- + th(r)e(onyl) + myr(istoyl).

af

(pharmacology) A long-acting recombinant form of insulin administered by subcutaneous injection in the treatment of type 1 and type 2 diabetes. Trade names include Levemir and possibly others.


gli-

# From glio-.
# Contraction of antihyperglycemic.

(pharmacology) Used to form names of antihyperglycemics.


-formin

(pharmacology) Used to form names of phenformin derivatives used as antihyperglycemics.


-glitazone

From glitazone, form gli- + th(i)az(olidinedi)one.

w:peroxisome proliferator-activated receptor gamma

(pharmacology) Used to form names of thiazolidinedione derivatives used as peroxisome proliferator activating receptor-γ agonists.


-glitazar

/ˈɡlɪt.əˌzɑɹ/

Blend of -glitazone + peroxisome proliferator-activated receptor.

blend

w:peroxisome proliferator-activated receptor alpha

(pharmacology) Used to form names of dual peroxisome proliferator activated receptors-α and -γ agonists.


remogliflozin etabonate

(pharmacology) A drug of the gliflozin class for the treatment of non-alcoholic steatohepatitis and type 2 diabetes.


mycophenolate mofetil

(pharmacology) A prodrug of mycophenolic acid, classified as a reversible inhibitor of inosine monophosphate dehydrogenase. It is an immunosuppressant combined with drugs such as ciclosporin and corticosteroids to prevent organ rejection after hepatic, renal, and cardiac transplants.


-nidazole

(pharmacology) Used to form names of metronidazole derivatives used as antiprotozoals and radiosensitizers.


-oxanide

(pharmacology) Used to form names of salicylanilides and analogs.


arte-

(pharmacology) Used to form names of artemisinin-related compounds used as antimalarial agents.


nifur-

(pharmacology) Used to form names of 5-nitrofuran derivatives.


suramin sodium

(pharmacology) A synthetic compound C₅₁H₃₄N₆Na₆O₂₃S₆ derived from urea, obtained as a white powder and administered intravenously to treat early stages of African sleeping sickness, onchocerciasis, and filariasis.


stibogluconic acid

sodium stibogluconate
sodium stibogluconate

(pharmacology) The conjugate acid of sodium stibogluconate


-oxacin

(pharmacology) Used to form names of nalidixic acid derivatives used as antibacterials.


-bactam

(pharmacology) Used to form names of β-lactamase inhibitors.


ipodate

en-noun

ipodate (countable and uncountable, plural ipodates)

(pharmacology) Alternative spelling of iopodate.


sodium iopodate

sodium ipodate (alternative)
ipodate sodium (alternative)

(pharmacology) A compound that is administered for use as a radiopaque medium in cholecystography and cholangiography.


iopodic acid

(pharmacology) Synonym of sodium iopodate.


amidotrizoic acid

From amido + tri(iodo) + (ben)zoic acid.

sodium amidotrizoate
sodium amidotrizoate

(pharmacology) The conjugate acid of sodium amidotrizoate


sodium amidotrizoate

(pharmacology) A salt C₁₁H₉I₃N₂NaO₄ (trademark Hypaque, Gastrografin, Urografin) administered in solution as a radiopaque medium for various forms of radiographic diagnosis.


maxacalcitol

(pharmacology) A calcitriol derivative, analog of vitamin D.


-kacin

Streptomyces kanamyceticus
Wikispecies:Streptomyces kanamyceticus

(pharmacology) Used to form names of kanamycin and bekanamycin derivatives (obtained from Streptomyces kanamyceticus) used as antibiotics.


-pristin

protein synthesis inhibitor
w:protein synthesis inhibitor

(pharmacology) Used to form names of streptogramin antibacterials, pristinamycin derivatives acting as protein synthesis inhibitors.


rifa-

(pharmacology) Used to form names of rifamycin derivatives used as antibiotics.


-fungin

(pharmacology) Used to form names of antifungal antibiotics.


-amivir

From (neur)ami(nidase) + -vir (“antiviral”).

(pharmacology) Used to form names of neuraminidase inhibitors used as antivirals.


-asvir

(pharmacology) Used to form names of hepatitis C virus NS5A inhibitors used as antivirals.


-buvir

(pharmacology) Used to form names of RNA polymerase (NS5B) inhibitors used as antivirals.


-cavir

From ca(rbocyclic) + -vir (“antiviral”).

(pharmacology) Used to form names of carbocyclic nucleosides used as antivirals.


-ciclovir

(pharmacology) Used to form names of bicyclic heterocycle compounds used as antivirals.


-fovir

From pho(sphonic acid) + -vir (“antiviral”).

(pharmacology) Used to form names of phosphonic acid derivatives used as antivirals.


-navir

(pharmacology) Used to form names of HIV protease inhibitors used as antivirals.


-previr

(pharmacology) Used to form names of hepatitis C virus protease inhibitors used as antivirals.


-tegravir

/ˈtɛɡ.ɹəˌvɪə/

/ˈtɛɡ.ɹəˌvɪɹ/

From (in)tegra(se) + -vir (“antiviral”).

(pharmacology) Used to form names of HIV integrase inhibitors used as antivirals.


-virine

reverse-transcriptase inhibitor
w:reverse-transcriptase inhibitor

(pharmacology) Used to form names of nonnucleoside reverse-transcriptase inhibitors (NNRTIs) used as antivirals.


-viroc

(pharmacology) Used to form names of chemokine CC motif receptor 5 (CCR5) antagonists.


-virsen

From -vir- (“antiviral”) + -rsen (“antisense oligonucleotide”).

af

(pharmacology) Used to form names of antiviral antisense oligonucleotides.


foscarnet sodium

(pharmacology) A hydrated sodium salt Na₃CO₅P·6 H₂O that is administered intravenously to individuals infected with HIV to treat retinitis caused by a cytomegalovirus.


-arabine

(pharmacology) Used to form names of arabinofuranosyl derivatives.


-citabine

(pharmacology) Used to form names of cytarabine or azacytidine derivatives used as nucleoside antiviral or antineoplastic agents.


ddC

(pharmacology) Abbreviation of dideoxycytidine.


-ribine

(pharmacology) Used to form names of ribofuranosyl derivatives of the pirazofurin type.


-racil

(pharmacology) Used to form names of uracil type antineoplastics.


rubidomycin

en-noun

rubidomycin (countable and uncountable, plural rubidomycins)

From Latin rubidus (“red, reddish”) + -o- + -mycin (“antibiotic”).

af

(pharmacology) Alternative form of daunorubicin.


vin-

(pharmacology) Used to form names of vinca alkaloids.


-taxel

(pharmacology) Used to form names of taxane derivatives used as antineoplastics.


-platin

(pharmacology) Used to form names of platinum derivatives used as antineoplastic agents.


cyproterone acetate

(organic chemistry, pharmacology) The cyproterone ester of acetic acid that is an antiandrogen and progestin medication - C₂₄H₂₉ClO₄.


etynodiol diacetate

(organic chemistry, pharmacology) Synonym of etynodiol.


medroxyprogesterone acetate

/mɛˌdɹɒk.sɪ.pɹəˌd͡ʒɛ.stə.ɹəʊn ˈas.ɪ.teɪt/

/məˌdɹɑk.sɪ.pɹoʊˌd͡ʒɛ.stəˌɹoʊn ˈæs.əˌteɪt/

(pharmacology) Synonym of medroxyprogesterone, trademark Depo-Provera.


nirsevimab

There is another remedy under regulatory consideration, a monoclonal antibody shot developed by Sanofi and AstraZeneca, called nirsevimab. It is meant to be given at the hospital to babies who are born during the winter or in the fall, Jonathan Heinrichs, a Sanofi executive said in an interview.

2023 May 18, Christina Jewett, “F.D.A. Panel Recommends R.S.V. Vaccine to Protect Young Infants”, in The New York Times:

respiratory syncytial virus
respiratory syncytial virus

(pharmacology) A human recombinant monoclonal antibody used to prevent respiratory syncytial virus (RSV) infections in infants.


roxadustat

(organic chemistry, pharmacology) A drug used to treat anemia


tetrylammonium bromide

(pharmacology) A ganglionic blocking agent.


hexamethonium bromide

(pharmacology) A compound C₁₂H₃₀Br₂N₂ used as a ganglionic blocking agent in the treatment of hypertension.


suxamethonium chloride

(pharmacology) A basic synthetic compound used intravenously chiefly in the hydrated form C₁₄H₃₀Cl₂N₂O₄·2H₂O as a short-acting muscle relaxant and local anesthetic. It is an ester of choline with succinic acid.


tubocurarine chloride

(biochemistry, pharmacology) A toxic compound of the alkaloid class obtained chiefly from the bark and stems of a South American vine (Chondrodendron tomentosum of the family Menispermaceae) that in its dextrorotatory form constitutes the chief active constituent of curare and used in the form of its hydrated hydrochloride C₃₇H₄₁ClN₂O₆·HCl·5H₂O to produce relaxation of voluntary muscles before surgery and in tetanus, encephalitis, and poliomyelitis.


decamethonium bromide

(pharmacology) A synthetic salt C₁₆H₃₈Br₂N₂ used as a skeletal muscle relaxant.


docusate sodium

sodium docusate (alternative)
sodium dioctyl sulfosuccinate (alternative)
dioctyl sodium succinate (alternative)

(pharmacology) A laxative salt C₂₀H₃₇NaO₇S used to soften stools in the treatment or prevention of constipation.


PTX

en-noun

PTX (countable and uncountable, plural PTXs)

(pharmacology) Abbreviation of paclitaxel.


international nonproprietary name

international nonproprietary name (plural international nonproprietary names)

international nonproprietary names (plural)

World Health Organization
World Health Organization

(pharmacology) An official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient, as designated by the World Health Organization (WHO).


bictegravir

(pharmacology) A particular antiviral drug.


narlaprevir

(pharmacology) An antiviral drug for the treatment of a hepatitis


crack out

en-verb

crack out (third-person singular simple present cracks out, present participle cracking out, simple past and past participle cracked out)

cracks out (present singular third-person)
cracking out (participle present)
cracked out (participle past)
cracked out (past)

Look over there. That kid is cracking out.

(intransitive, drugs, slang) To show signs or symptoms of excessive crack cocaine use.

(transitive, drugs, slang) To intoxicate through the administration of crack cocaine.

Super Size Me 2: Holy Chicken!, Morgan Spurlock.
"So part of the reason why this is the fastest growing chain is because their cracking us out on MSG"

(transitive, drugs, slang, by extension) To intoxicate, similar to a crack high, through administration of a comparable substance.


cracked out

en-adj

cracked out (comparative more cracked out, superlative most cracked out)

more cracked out (comparative)
most cracked out (superlative)
cracked-out (alternative)

You need to slow down, yo. You're starting to look all cracked out.

Be kind by gently tapping that cracked-out reveler who resembles a human vibrator and whispering, "Pride is a feeling..."

(drugs, slang) Appearing excessively high or hooked on crack cocaine.


DOAC

(pharmacology) Initialism of direct oral anticoagulant.


baricitinib

Baricitinib, a JAK1/JAK2 inhibitor, is approved for patients with RA in the US, with a dosage limited to 2 mg every day in combination with a csDMARD, or as monotherapy in patients with RA refractory to a bDMARD, based on phase III trial results.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2168:

rheumatoid arthritis
rheumatoid arthritis

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including rheumatoid arthritis and COVID-19.


drug-naive

drug naive (alternative)
drug-naïve (alternative)
drug naïve (alternative)

D-Amphetamine improved information processing but had no effect on inhibitory control in drug-naive controls.

2008, Richard J. Abbott, Michael G. Ritchie, Peter M. Hollingsworth, Speciation in Plants and Animals: Pattern and Process : Papers of a Theme Issue:

To address these issues, they recorded electroencephalographic sleep in 20 drug-naive schizophrenic patients, 20 drug-free but previously medicated schizophrenic patients, and 15 normal controls.

1992, Digest of Neurology and Psychiatry:

(pharmacology, medicine) Lacking tolerance to or dependence on the pharmacological effect of a drug.


cefiderocol

From cef- (“cefalosporanic acid derivative”) + (s)idero(phore) + (cate)chol.

af

urinary tract infection
urinary tract infection

(pharmacology) A siderophore cephalosporin antibiotic used to treat complicated urinary tract infections when no other options are available.


ziresovir

(pharmacology) The antiviral drug N-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-2H-1λ6,4-benzothiazepin-4-yl)-6-methylquinazolin-4-amine


sisunatovir

(pharmacology) A drug that is an inhibitor of respiratory syncytial virus replication.


halicin

After HAL 9000, an artificial intelligence in the Space Odyssey series.

(organic chemistry, pharmacology) The heterocycle 5-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1,3,4-thiadiazol-2-amine


proton pump inhibitor

en-noun

proton pump inhibitor (plural proton pump inhibitors)

proton pump inhibitors (plural)
proton-pump inhibitor (alternative)

(pharmacology) Any chemical that totally or partly decreases one or more proton pumps from functioning.

prootonipumba inhibiitor

any chemical decreasing the function of proton pumps


CCB

calcium channel blocker
calcium channel blocker#English

(pharmacology) Abbreviation of calcium channel blocker.


TNF inhibitor

tumor necrosis factor
tumor necrosis factor

(pharmacology) A pharmaceutical drug that suppresses the physiologic response to the tumor necrosis factor (TNF).


continuous erythropoietin receptor activator (plural continuous erythropoietin receptor activators)

(pharmacology) A generic term for drugs in a new class of third-generation erythropoiesis-stimulating agents (ESAs).


lithium oxybutyrate

(pharmacology) An antimanic drug that possesses a neurotropic activity similar to that of lithium carbonate.


molnupiravir

From -vir. Coined by Merck in 2020, named after Thor's Hammer; from Old Norse Mjǫllnir

(pharmacology) An antiviral drug developed to treat COVID-19, the first to obtain regulatory approval in the Western World, from the MHRA in the United Kingdom.


ERAA

ERAA (countable and uncountable, plural ERAAs)

estrogen receptor agonist/antagonists
w:estrogen receptor agonist/antagonists

(pharmacology) Initialism of estrogen receptor agonist/antagonists.


SERD

SERD (countable and uncountable, plural SERDs)

selective estrogen receptor degrader
w:selective estrogen receptor degrader

(pharmacology) Initialism of selective estrogen receptor degrader.


atypical antipsychotic

atypical antipsychotic (plural atypical antipsychotics)

Coordinate term: typical antipsychotic

(pharmacology) Any of a group of antipsychotic drugs largely introduced after the 1970s and used to treat mental disorders.


effervescent tablet

effervescent tablet (plural effervescent tablets)

(pharmacology) A tablet of compressed powder, designed to dissolve in water and release carbon dioxide.


carbon tablet

effervescent tablet
effervescent tablet#English

(pharmacology) Synonym of effervescent tablet


nirmatrelvir

(pharmacology, neologism) An antiviral drug developed to treat COVID-19, the second to obtain regulatory approval in the Western World, from the FDA in the United States of America.

Paxlovid

trade name compounded drug containing nirmatrelvir and ritonavir


Pfizermectin

Blend of Pfizer + ivermectin.
Coined by conspiracy theorists in 2021. From the drug pharmacokinetics of nirmatrelvir being similar to ivermectin, and thus supposedly being evidence that Pfizer blocked ivermectin from use by issuing a newly patented medicine of the same function, similar to how drug companies block generic drugs by issuing minor variants of drugs soon to come off patent and receiving a new patent extension.

(pharmacology, slang, conspiracism, neologism) Synonym of nirmatrelvir (Paxlovid)


Pepcid

(pharmacology) Genericized trademark of famotidine


pepcid

(pharmacology) Lowercase version of Pepcid


acetohydroxamate

acetohydroxamic acid
acetohydroxamic acid

(biochemistry, pharmacology) The conjugate base of acetohydroxamic acid, which coexists with it in solution according to pH balance and buffering systems (as with the conjugate forms of all weak acids).

(biochemistry, pharmacology) Any salt or ester of acetohydroxamic acid.


neridronate

(pharmacology) The conjugate base, or any salt or ester, of neridronic acid. Used as a medication to inhibit bone loss in disorders of bone metabolism.

neridronic acid

coordinate as an acid versus a base, but synonymous in the practical sense that the conjugate base and conjugate acid coexist in solution


olpadronate

From olpadronic acid + -ate (“salt or ester”).

af

(pharmacology) The conjugate base, or any salt or ester, of olpadronic acid. Used as a medication to inhibit bone loss in disorders of bone metabolism.


salicylsalicylate

(organic chemistry, pharmacology) Synonym of salsalate


pacritinib

Pacritinib is a JAK2 and IL-1 receptor–associated kinase 1 inhibitor also being evaluated for the treatment of myelofibrosis. Blocking IL-1 and Toll receptor signaling might offer some interesting opportunities for autoimmune disease treatment.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2173:

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of myelofibrosis.


abrocitinib

Another JAK1-selective jakinib, abrocitinib, has been evaluated in phase III trials in atopic dermatitis and plaque psoriasis (61, 62), showing efficacy in both diseases. AEs included herpes simplex and herpes zoster infection, appendicitis, pancreatitis, and IBD.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2172:

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of atopic dermatitis.


cefpodoxime proxetil

(pharmacology) A cephalosporin antibiotic used to treat a wide variety of bacterial infections.


wet weed

From wet + weed, so named from the practice of dipping weed into PCP juice causing to the weed to become wet.

Have you ever smoked wet weed?

(drugs) Marijuana infused with phencyclidine (PCP) or formaldehyde.


atophan

(organic chemistry, pharmacology) Synonym of cinchophen (“analgesic drug”)


estradiol valerate

(organic chemistry, pharmacology) The estradiol ester of valeric acid that is an estradiol medication - C₂₃H₃₂O₃.


momelotinib

Momelotinib is a JAK1/JAK2 inhibitor as well as an activin receptor–like kinase (ALK1) inhibitor. Because ALK1 is a receptor for bone morphogenic proteins, momelotinib is undergoing testing for the treatment of myelofibrosis (78).

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, being developed as a drug to treat myelofibrosis.


testosterone undecanoate

(organic chemistry, pharmacology) The testosterone ester of undecanoic acid that is an androgen and anabolic steroid medication - C₃₀H₄₈O₃.


fentanyl citrate

en-noun

fentanyl citrate (plural fentanyl citrates)

(pharmacology) The citrate salt of fentanyl, a potent opioid agonist.


cerebroprotectant

(pharmacology) A substance that offers cerebroprotection.


balapiravir

(pharmacology) An antiviral drug used to treat dengue fever.


tirzepatide

The drug is called tirzepatide and will be sold under the name Zepbound. It joins a class of new medications that are transforming obesity, a condition that affects 100 million American adults and is linked to a spectrum of diseases including diabetes, heart disease, sleep apnea, liver disease, kidney disease and joint pain.

2023 November 8, Gina Kolata, “F.D.A. Approves New Obesity Drug That Will Compete With Wegovy”, in The New York Times:

(pharmacology) A medication for the treatment of type 2 diabetes.


tretinoin tocoferil

(organic chemistry, pharmacology) A hybrid compound composed of alpha-tocopherol esterified with retinoic acid.


hydrodolasetron

(pharmacology) A drug chemical with the formal name (10-hydroxy-8-azatricyclo[5.3.1.0^(3,8)}]undecan-5-yl) 1H-indole-3-carboxylate


temsavir

(pharmacology) An HIV inhibitor with the molecular formula C₂₄H₂₃N₇O₄.


bread pill

(pharmacology) A placebo consisting of breadcrumbs or other inactive substances.


deucravacitinib

Deucravacitinib (BMS-986165) has shown efficacy in a psoriasis trial (65) and significantly greater American College of Rheumatology 20% improvement rates compared to placebo in patients with PsA.

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of moderate-to-severe plaque psoriasis.


lecanemab

(pharmacology) A drug for the treatment of Alzheimer's disease.


sDMARD

Coordinate term: bDMARD

(pharmacology) Initialism of synthetic disease-modifying antirheumatic drug.


bDMARD

Coordinate term: sDMARD

(pharmacology) Initialism of biological disease-modifying antirheumatic drug.


anfibatide

Anfibatide is an anticoagulant C-type lectin-like protein purified from the venom of the sharp-nosed viper (Deinagkistrodon acutus). […] The anticoagulant activity of anfibatide is due to its strong binding to human platelet glycoprotein Ib α-chain (GPIbα), which inhibits the binding of GPIbα with von Willebrand factor (VWF) and thrombin^(124,125) (Fig. 6a).

2022 June 10, Oliveira, A.L., Viegas, M.F., da Silva, S.L. et al., “The chemistry of snake venom and its medicinal potential”, in Nature Reviews Chemistry, volume 6, →DOI, page 462:

(pharmacology) An antithrombotic agent binding to the GPIbα subunit of the glycoprotein Ib-IX-V complex, purified from the venom of the sharp-nosed viper (Deinagkistrodon acutus).


therapeutic index

therapeutic index (plural therapeutic indexes or therapeutic indices)

therapeutic indexes (plural)
therapeutic indices (plural)

(pharmacology) The ratio of the median toxic dose of a drug to its median effective dose, used to gauge the safety of a particular medication. A low therapeutic index indicates that the drug is easily overdosed.


piptazobactam

(pharmacology) A combination antibiotic containing piperacillin, a beta-lactam antibiotic, and tazobactam, a beta-lactamase inhibitor.


dope set

(slang, drugs) A street or section of a town or city where drugs are either used or sold.


FOLFOX

(pharmacology) A combination chemotherapy regimen made up of the drugs folinic acid (leucovorin, FOL), fluorouracil (5-FU, F), and oxaliplatin (OX).


gepant

(pharmacology) Any of a class of drugs that are calcitonin gene-related peptide (CGRP) inhibitors used to treat migraine.


DPV

(pharmacology) Initialism of dapivirine.


Claritin

From Latin clāritās + -in (“a pharmaceutical product”).

(Canada, US, pharmacology) A brand of loratadine.


brown heroin

From brown + heroin, from the light to medium brown colour as opposed to black tar heroin.

(drugs) A type of heroin, powdery and brown in color, that is usually snorted or smoked.


TKI

tyrosine kinase inhibitor
w:tyrosine kinase inhibitor

(pharmacology) Initialism of tyrosine kinase inhibitor.


metonitazene

Recent chatter on drug fora indeed points at a renewed interest in these “nitazene” 2-benzylbenzimidazole opioids, and their (online) availability seems to be increasing. Metonitazene, for example, was recently found in seized material in the U.S.,⁴¹ where its appearance seems to be growing.⁴²

2021, Marthe M. VandeputteKatleen Van Uytfangheet al., “Synthesis, Chemical Characterization, and μ‑Opioid Receptor Activity Assessment of the Emerging Group of “Nitazene” 2‑Benzylbenzimidazole Synthetic Opioids”, in ACS Chemical Neuroscience, volume 12, number 7, →DOI, page 1242:

Harm reduction groups in the area had been unaware of a potentially dangerous opioid, metonitazene, that surfaced in the sample, he said. Weeks later, the Centers for Disease Control and Prevention issued a report about the substance, an indication of how drug checking can offer timely warnings for users.

2022 December 24, Noah Weiland, “A High-Tech Strategy for Keeping Drug Users Safe: Analyzing Their Fentanyl”, in The New York Times:

(pharmacology) A potent synthetic opioid analgesic of the nitazene group, used as an illicit drug.


guancydine

(pharmacology) An adrenergic release inhibitor with IUPAC name 1-cyano-2-(2-methylbutan-2-yl)guanidine.


isunakinra

(pharmacology) A particular interleukin-1 receptor inhibitor.


cancroine

(pharmacology, obsolete) A substance extracted from cancer juice, possibly neurine citrate.


daprodustat

(organic chemistry, pharmacology) A medication used to treat anemia due to chronic kidney disease.


TNFi

(pharmacology) Initialism of TNF inhibitor.


ACEi

Alternative form: ACEI

(pharmacology) Initialism of ACE inhibitor.


ACEI

Alternative form: ACEi


photoCORMs

(pharmacology) Light-activated carbon monoxide releasing molecules.


antihyperlipoproteinemic

en-adj

antihyperlipoproteinemic (comparative more antihyperlipoproteinemic, superlative most antihyperlipoproteinemic)

more antihyperlipoproteinemic (comparative)
most antihyperlipoproteinemic (superlative)


antihyperlipoproteinemic

(pharmacology) Any drug that counters hyperlipoproteinemia.


penicillin O

(pharmacology) A type of penicillin, C₁₃H₁₆N₂O₄S, isolated from Penicillium chrysogenum that is used to treat bacterial infections.


ethiazide

(pharmacology) A benzothiadiazine sulfonamide diuretic.


avatrombopag

Aplastic anemia (AA) secondary to radiotherapy presents a difficult situation in the treatment of both the malignant tumor and AA itself. We aimed to evaluate the efficacy of avatrombopag (AVA), a thrombopoietin receptor agonist, in patients with AA secondary to chemoradiotherapy.

2023 January, Yarong Chi, Qinglin Hu, Chen Yang, Miao Chen, Bing Han, “Avatrombopag is effective in patients with chemoradiotherapy-induced aplastic anemia: a single-center, retrospective study”, in Experimental Hematology, volume 117, →DOI, page 62:

(pharmacology) A medication used to treat certain conditions that lead to thrombocytopenia.


lusutrombopag

Currently, four TPO-RAs have been launched in the United States and Europe, namely romiplostim, eltrombopag (ELT), avatrombopag (AVA), and lusutrombopag [9].


LAMA

Coordinate term: SAMA

(pharmacology) Initialism of long-acting muscarinic antagonist.


ceftaroline fosamil

(pharmacology) A prodrug of ceftaroline.


diclofenac epolamine

(organic chemistry, pharmacology) A prodrug of diclofenac.


andexanet alfa

(pharmacology) An antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding.


-entan

Clipping of endothelin receptor antagonist.

clipping

(pharmacology) An endothelin receptor antagonist.


aprocitentan

/ˌæpɹəsɪˈtɛntæn/

From [Term?] + -entan (“endothelin receptor antagonist”).

af

(pharmacology) An endothelin receptor antagonist researched for its effect on resistant hypertension.


darusentan

/ˌdæɹəˈsɛntæn/

(pharmacology) An endothelin receptor antagonist developed for the potential treatment of resistant hypertension.


enrasentan

/ˌɛnɹəˈsɛntæn/


fandosentan

(pharmacology) An endothelin receptor A antagonist.


nebentan

(pharmacology) A potent endothelin receptor A antagonist.


sparsentan

(pharmacology) An antagonist to endothelin receptor type A and angiotensin II receptor type 1, used in the treatment in primary immunoglobulin A nephropathy.


nupercaine

The method of anesthetizing the mother is as follows: When the pains are every five minutes and quite strong or the cervix is five cm. dilated along with regular and strong pains, the mother is given a block anesthesia of 1 cc. of 1:200 nupercaine, 1 cc. of 10 per cent dextrose with .05 cc. of 1:1000 adrenalin.

1951 February, Forrest H. Howard, “The Physiologic Position for Delivery”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 99:


lidoderm

Trade name, from lidocaine and Ancient Greek δέρμα (dérma, “skin”).

What medication can John use to help control his pain? […] He may also benefit from applying a lidoderm to the painful area or using a mild opioid

2007, Yvonne M. D'Arcy, Pain Management: Evidence-Based Tools and Techniques for Nursing Professionals, Marblehead, MA: HCPro, Inc., →ISBN, page 70:

Conditions that result in increased lidocaine absorption and hence increase its blood concentrations include:
• Application of a lidoderm patch for longer than 12 hours/day
• Application of more than three patches at a time

2011, Maggy G. Riad, “Local Anesthetics: Lidocaine transdermal”, in Raymond S. Sinatra, Jonathan S. Jahr, J. Michael Watkins-Pitchford, editors, The Essence of Analgesia and Analgesics, Cambridge: Cambridge University Press, →ISBN, page 290:

(pharmacology) A transdermal patch of lidocaine, used to help reduce pain or itching.


donanemab

(pharmacology) An experimental drug for the treatment of Alzheimer's disease.


naphthoylindole

From naphthalene + -yl + indole, because the structure of the drug contains a naphthalene system connected to an indole system by a carbonyl group.

(pharmacology) A class of synthetic psychoactive drugs with cannabinoidergic effects.


IMiD

immunomodulatory imide drug
w:immunomodulatory imide drug

(pharmacology) Acronym of immunomodulatory imide drug.


pimodivir

With its antiviral drug, pimodivir, J&J aims to help treat influenza patients who have developed resistance to existing antiviral drugs as well as address the lack of approved medications for people hospitalized with the virus, the company said.

2017 June 14, Divya Grover, “Johnson & Johnson's flu drug succeeds in mid-stage trial”, in Reuters:

(pharmacology) An antiviral drug developed as a treatment for influenza.


quinophan

(organic chemistry, pharmacology) Synonym of cinchophen


diiodohydroxyquin

(pharmacology) Synonym of diiodohydroxyquinoline


pseudotolerance

LL-Q1860 (eng)-Flame, not lame-pseudotolerance.wav

(pharmacology) A patient's requirement for an increased dose of a drug for reasons other than the patient's body having come to tolerate the existing dose.


minimum inhibitory concentration

en-noun

minimum inhibitory concentration (plural minimum inhibitory concentrations)

minimum inhibitory concentrations (plural)
minimal inhibitory concentration (alternative)

(microbiology, pharmacology) The lowest concentration of a chemical (usually a drug) which prevents visible in vitro growth of bacteria or fungi.


pasotuxizumab

From [Term?] + -tu- (“tumor”) + -xi- (“chimeric”) + -zumab (“humanized monoclonal antibody”).

af

Pasotuxizumab (AMG 212) is a canonical BiTE antibody targeting PSMA [77]. The anti-tumor activity which was defined by PSA level decrease was dose-dependent. Two patients achieved long-term PSA responses with more than 1 year of treatment at doses of 40 μg/d and 80 μg/d, respectively.

2021 May 26, Shujie Zhou, Mingguo Liu, Fei Ren, Xiangjiao Meng, Jinming Yu, “The landscape of bispecific T cell engager in cancer treatment”, in Biomarker Research, volume 9, →DOI, article 38, page 4:

(pharmacology) A bi-specific T-cell engager monoclonal antibody developed for the treatment of prostate cancer.


MTD

en-noun

MTD (countable and uncountable, plural MTDs)

Among 10 patients in the maximum tolerated dose (MTD) cohort at the dose of 400 μg/d, the overall response rate (ORR) was 70% with 5 MRD-negative CR, 1 very good partial response (VGPR), and 1 PR.

maximum tolerated dose
w:maximum tolerated dose

(pharmacology) Initialism of maximum tolerated dose.


JAKi

(pharmacology) Initialism of Janus kinase inhibitor.


JAKinib

From JAK (“Janus kinase”) + -in- + -ib (“small molecule inhibitor”).

af

Blocking the JAK-STAT pathway with the Janus kinase inhibitor (JAKinib) baricitinib or tofacitinib reduces the expression of IFN-regulated genes (IRGs) in TNF-activated FLSs. […] The IFN-signature might be a promising biomarker for the efficient and personalized use of new treatment strategies for RA, such as JAKinibs.

2019 July 8, Michael BonelliKarolina DalwigkAlexander PlatzerIsabel Olmos CalvoSilvia HayerBirgit Niederreiteret al., “IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes”, in Experimental & Molecular Medicine, volume 51, →DOI, page 1:

(pharmacology) A Janus kinase inhibitor.


filgotinib

Both upadacitinib and filgotinib have been referred to as “second-generation jakinibs” since they both preferentially inhibit JAK1 in vitro but their clinical efficacy and safety, to a large extent, is similar to pan-jakinibs in RA, although anemia and herpes zoster are seen less often with filgotinib.

(pharmacology) A medication, belonging to the class of Janus kinase inhibitors, used for the treatment of rheumatoid arthritis.


upadacitinib

Upadacitinib monotherapy has also been shown to be more effective than MTX in MTX-naive patients with RA (24). Both upadacitinib and filgotinib have been referred to as “second-generation jakinibs” since they both preferentially inhibit JAK1 in vitro but their clinical efficacy and safety, to a large extent, is similar to pan-jakinibs in RA, […]

ankylosing spondylitis
ankylosing spondylitis

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several immune-mediated diseases such as rheumatoid arthritis, ankylosing spondylitis, and atopic dermatitis.


peficitinib

Peficitinib, a pan-JAK inhibitor, is approved in Japan, Republic of Korea, and Taiwan for the treatment of RA in patients with an incomplete response to csDMARDs (19, 20). Tofacitinib, baricitinib, and peficitinib have shown clinical, functional, and radiographic efficacy, after failure of a csDMARD, prior to treatment with a bDMARD, or after treatment with a bDMARD.

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of rheumatoid arthritis.


decernotinib

Developed to target the kinase domain of JAK3, decernotinib (VX-509) showed selective in vitro inhibition of JAK3 over the other JAKs and efficacy in RA (73, 74). However, a CYP3A4-mediated drug–drug interaction was also described, potentially limiting the use of decernotinib; development of this molecule has currently been halted (75).

(pharmacology) An experimental medication belonging to the class of Janus kinase inhibitors.


brepocitinib

PF-06826647 is a TYK2-selective jakinib (68) currently in trials for the treatment of psoriasis, UC, and hidradenitis suppurativa; brepocitinib is a TYK2/JAK1 inhibitor that was assessed in a phase II trial of psoriasis where clinical responses were seen with all doses (69).


itacitinib

The JAK1-selective inhibitor, itacitinib, is currently being assessed in multiple clinical trials for oncologic indications as well as for chronic and acute GVHD, including GVHD prophylaxis.


ritlecitinib

Ritlecitinib is an irreversible covalent inhibitor that binds to a distinct cysteine residue in the JAK3 catalytic domain, which other JAK family members lack. […] Ritlecitinib was found to be superior to placebo in a phase II study in RA patients with an inadequate response to MTX (76).

(pharmacology) A medication belonging to the class of Tec/Janus kinase inhibitors, used for the treatment of alopecia areata.


fedratinib

Fedratinib is a selective JAK2 inhibitor approved for primary and secondary myelofibrosis. An important AE observed with fedratinib is Wernicke’s encephalopathy, which has been observed in patients taking the highest daily dosage (500 mg) (70).

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of myeloproliferative diseases including myelofibrosis.


delgocitinib

Delgocitinib (JTE-052) is a topical jakinib approved in Japan for atopic dermatitis and oclacitinib, a JAK1/JAK2/JAK3 inhibitor, is approved for canine allergic dermatitis.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2170:

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of atopic dermatitis.


cerdulatinib

Another JAK/Syk inhibitor, cerdulatinib (PRT062070), has been tested in several trials for the treatment of leukemia and lymphoma, and a topical formulation is being tested in phase II trials in patients with vitiligo.

(pharmacology) A medication belonging to the class of Syk/Janus kinase inhibitors, being developed for treatment of hematological malignancies.


gusacitinib

Gusacitinib (ASN002) is an oral JAK/Syk inhibitor that showed clinical efficacy, associated with decreased expression of inflammatory biomarkers, in a phase II trial in atopic dermatitis (77).

(pharmacology) An experimental medication belonging to the class of Syk/Janus kinase inhibitors.


gandotinib

Gandotinib is a JAK2-selective inhibitor that has potential increased potency for the JAK2^(V617F) mutant kinase and has shown efficacy in myeloproliferative neoplasm (72), although there are currently no ongoing clinical investigations of gandotinib.


DMOAD

(pharmacology) Initialism of disease-modifying osteoarthritis drug.


pseudotolerant

en-adj

pseudotolerant (comparative more pseudotolerant, superlative most pseudotolerant)

more pseudotolerant (comparative)
most pseudotolerant (superlative)

LL-Q1860 (eng)-Flame, not lame-pseudotolerant.wav

(pharmacology) Requiring an increased dose of a drug for reasons other than one's body having come to tolerate the existing dose.


LMWH

en-noun

LMWH (countable and uncountable, plural LMWHs)

Coordinate term: UFH

low-molecular-weight heparin
w:low-molecular-weight heparin

(pharmacology) Initialism of low-molecular-weight heparin.


UFH

Coordinate term: LMWH

(pharmacology) Initialism of unfractionated heparin.


andexanet

(pharmacology) Synonym of andexanet alfa.


beta blockade

beta blockade (usually uncountable, plural beta blockades)

beta blockades (plural)
beta-blockade (alternative)
betablockade (alternative)

(pharmacology) The action of a beta blocker.


inverse agonist

inverse agonist (plural inverse agonists)

(pharmacology) A drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that of the agonist.


borofax

A proper dressing contributes immensely to the comfort of the patient, as well as to a satisfactory cosmetic result. After the wound is properly sutured, vaseline or borofax is lightly applied along the suture line.

1951 February, Charles E. Gurney, Verner V. Lindgren, “Early Care of Traumatic Wounds of the Face”, in Northwest Medicine, volume 50, number 2, Portland, Ore.: Northwest Medical Publishing Association, page 93:

(pharmacology) An ointment containing boric acid, applied to the skin as an antiseptic.


neoprontosil

In the field of therapeutic aids, chemotherapy and antibiotics have been completely developed since that time. We had prontosil and neoprontosil and thought we were very fortunate.

1951 July, Richard D. Reekie, “Critical Analysis of Recent Advances in Gynecology”, in Northwest Medicine, volume 50, number 7, Portland, Ore.: Northwest Medical Publishing Association, page 508:

(pharmacology) A soluble form of prontosil.


SASP

SASP (countable and uncountable, plural SASPs)

(pharmacology) Abbreviation of salazosulfapyridine.


sulfathalidine

The bowel is prepared preoperatively with neomycin and sulfathalidine. A wide transverse lower abdominal incision is used.

1954 February 15, Oswald S. Lowsley, Thomas H. Johnson, Antonio E. Rueda, “Operation for Urinary Diversion”, in Modern Medicine, volume 22, number 4, Minneapolis, Minn.: Modern Medicine Publications, Inc., page 89:

(pharmacology, dated) Synonym of phthalylsulfathiazole.


hydrosulphosol

A former trademark of E. C. Lientz & Co., Inc.

Hydrosulfosol in oil with gentle pressure dressings may promote healing after severe burns of the eye. For conjunctival and corneal burns, 0.5% cortisone is used locally on dressings and, after the dressings are omitted, four times daily.

1954 February 15, William B. Clark, Edwin B. Dunphy, S. Rodman Irvine, Lawrence T. Post, Derrick T. Vail, “Early Treatment of Eye Injury”, in Modern Medicine, volume 22, number 4, Minneapolis, Minn.: Modern Medicine Publications, Inc., page 146:

(pharmacology, dated) Synonym of calsulfhydryl.


calsulfhydryl

Since 1942 several clinical investigations have been published describing the increased healing rate of corneal wounds treated with calsulfhydryl (Hydrosulphosol¹). […] The present study was undertaken therefore to evaluate the effect of calsulfhydryl on a controlled series of rabbits corneas injured by abrasion or by acid or alkali burns.

1953 December, Robert E. Rocknem, “Evaluation of wounds of the rabbit cornea treated with calsulfhydryl (Hydrosulphosol)”, in Archives of Ophthalmology, volume 50, number 6, →DOI, page 696:

(pharmacology, dated) A glycerol–water solution containing calcium polysulfides and calcium thiosulfates, formerly used for the treatment of chemical burns of the eye and other conditions.


drug holiday

(pharmacology) A time period when a patient ceases taking medication.


(organic chemistry, pharmacology) Synonym of carfentanil


Wildnil

(organic chemistry, pharmacology) Synonym of carfentanil (trade name)


mife

The miso/mife combination is becoming increasingly popular: In 2011, it accounted for 36 percent of all abortions before nine weeks of gestation, and it’s often considered the gold standard of medication abortion, with an estimated success rate that is nearly 10 percent higher than using miso alone (92 to 95 percent and 80 to 85 percent, respectively).

2014 June 27, Erica Hellerstein, “The Rise of the DIY Abortion in Texas”, in The Atlantic:

(pharmacology, informal) Clipping of mifepristone.


norclobazam

(pharmacology) A metabolite of clobazam in which a methyl group has been removed from a nitrogen atom. IUPAC name is 7-chloro-5-phenyl-1H-1,5-benzodiazepine-2,4-dione.


firsocostat

(pharmacology) An acetyl-CoA carboxylase inhibitor drug.


penicillin VK

(pharmacology) Synonym of phenoxymethylpenicillin.


iberdomide

Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE).

2022 March 17, Joan T. Merrill, Victoria P. Werth, Richard Furie et al., “Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus”, in The New England Journal of Medicine, volume 386, number 11, →DOI, page 1034:

systemic lupus erythematosus
systemic lupus erythematosus

(pharmacology) A derivative of thalidomide used experimentally for the treatment of multiple myeloma and systemic lupus erythematosus.


HHCH

Japanese: HHCH (HHCH) (hexahydrocannabihexol)

(organic chemistry, pharmacology) Initialism of hexahydrocannabihexol.


iptacopan

(organic chemistry, pharmacology) A medication used to treat paroxysmal nocturnal hemoglobinuria.


b.i.d.

en-adv

b.i.d. (comparative more b.i.d., superlative most b.i.d.)

more b.i.d. (comparative)
most b.i.d. (superlative)


t.i.d.

t.i.d. (comparative more t.i.d., superlative most t.i.d.)

more t.i.d. (comparative)
most t.i.d. (superlative)

(medicine, pharmacology) Three times a day


enzybiotic

(pharmacology) An experimental enzyme used in antibacterial therapy.


Placidyl

en-noun

Placidyl (countable and uncountable, plural Placidyls)

Marketing name, apparently from placid + -yl.

His horror of insomnia, compounded with a family history of compulsive worrying, caused him to down three or four Placidyls, Seconals, Quaaludes, or Tuinals almost every night—and often it was a combination of all four.

1985, Priscilla Presley, Sandra Harmon, Elvis and Me, Putnam, →ISBN, page 151:

(pharmacology) Trade name of ethchlorvynol, a sedative.


parent drug

(pharmacology) The initial compound in a biotransformation reaction, requiring metabolism for activation.


Evzio

(pharmacology) An opioid antagonist indicated for the emergency treatment of a known or suspected opioid overdose.


Nyxoid

(pharmacology) A single-dose nasal spray used for the emergency treatment of an opioid overdose.


hot piping

(slang, drugs) A form of smoking of illegal narcotics using tinfoil, a lighter and a straw to ingest the drugs.


dope stick

dope sticks (plural)
dope-stick (alternative)
dopestick (alternative)

He hands the dope-stick to his partner who drives with one hand on the steering-wheel and the other toking on the blunt.

2010, Reverend James R. Harris, Jesus in Columbus, page 6:

She shrugged and set down the dope stick she'd been puffing on.

2012, Alan Dean Foster, The Moment of the Magician:

Before he could finish his dope stick, a dope fiend came up asking for a twenty rock of crack.

2014, Mr. Mafia, The Last Birdman, page 40:

(slang, drugs) A marijuana joint or cigar laced with cocaine.


α-Methylfentanyl

(pharmacology, drugs) An opioid analgesic that is an analog of fentanyl.


vadadustat

(organic chemistry, pharmacology) A drug used to treat symptomatic anemia associated with chronic kidney disease.


LASA

(pharmacology) Initialism of look alike sound alike. (referring to pharmaceuticals that are visually similar in physical appearance or packaging and similar in their names, orthographies, or phonetics).


isoxepac

non-steroidal anti-inflammatory drug
non-steroidal anti-inflammatory drug

(pharmacology) A non-steroidal anti-inflammatory drug with analgesic activity. It is also used as an intermediate in the synthesis of olopatadine hydrochloride.


amenamevir

Amenamevir … exerts antiviral action by inhibiting the enzymatic activity of a virus-derived helicase.

2019, Maeda H, Nakamura H, Kikukawa Y. Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster. Nihon Yakurigaku zasshi. Folia Pharmacologica Japonica. Volume 153(1). PMID: 30643090. pages 35-43

(pharmacology) An oxadiazole phenyl derivative, an antiherpes agent that does not have a nucleic acid-like structure.


duoperone

(pharmacology) A phenothiazine, C₂₈H₂₆F₄N₂OS with neuroleptic and antiemetic properties. It has a prolonged duration of action.


dosmalfate

Dosmalfate … has been developed and marketed in some countries for therapeutic use in the healing of gastric and duodenal ulcers.

2003, Isabel Villegas, Carmen La Casa, Aurelio Orjales, Catalina Alarcón de la Lastra. Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats. European Journal of Pharmacology. Volume 460(2-3). page 210

(pharmacology) A diosmin heptakis (hydrogen sulfate) aluminium complex, a non-systemic cytoprotective drug.


FGA

Coordinate term: SGA

first-generation antipsychotic
w:typical antipsychotic

(pharmacology) Initialism of first-generation antipsychotic.


cyclohexyloxycarbonyloxyethyl

/ˌsaɪkləʊˌhɛksɪlˌɒksɪkˌɑːbənɪlˌɒksiˈɛθɪl/

/ˌsaɪkləʊˌhɛksɪlˌɒksiˌkɑːbənɪlˌɒksiˈɛθɪl/

From cyclohexyl + oxy + carbonyl + oxy + ethyl.

compound

(pharmacology) The ester in which prodrug form candesartan is prepared for administration in order to increase its bioavailability.


biobetter

From bio- + better. Coined by Indian business executive G. V. Prasad, managing director of Dr. Reddy's Laboratories, in 2007.

coinage

Coordinate term: biosimilar

In general, originators have short-term options available, such as patent litigation, but should focus on sustainable long-term strategies such as development of biobetters or incorporating biosimilars as complements to existing products.

2016 February, Daniel Casey, “Key strategic factors for stakeholders in the current global biosimilar market”, in Drug Discovery Today, volume 21, number 2, →DOI, page 208:

(pharmacology) A medication developed by modifying an approved biological drug to enhance its properties (e.g., improved efficacy, higher selectivity or lower toxicity).


off the shits

(slang, drugs) Extremely high; tripping, wired, etc..


proemetic

en-adj

proemetic (comparative more proemetic, superlative most proemetic)

more proemetic (comparative)
most proemetic (superlative)

(pharmacology) That induces emesis (vomiting).


proemetic

(pharmacology) An agent that induces emesis (vomiting).


ceiling effect

(pharmacology) The process of increasing doses of a given medication to have progressively smaller incremental effect.


time delay toxin activation

(oncology, pharmacology) A process for producing a class of chemotherapy drugs which can be administered in a nontoxic form and, subsequent to a time delay, allows for a differential concentration in the target cancer or invasive tissues or cells, minimizing the toxicity to healthy cells, thereby reducing the adverse side effects of chemotherapy.


Eagle effect

Named after Harry Eagle who first described it.

(microbiology, pharmacology) A phenomenon observed in which higher concentrations of antibiotics paradoxically improve bacterial survival.


pamoic

(chemistry, pharmacology) Of or relating to pamaquine.


Colombian cold

(slang, somewhat humorous, drugs) A cold or sinus infection resulting from the use of cocaine.


salazopyrin

Modern drug treatment with salazopyrin is very effective and will usually control the symptoms. If the disease proves severe, the colon or a portion of it can be removed.

1987, “Colon and colitis”, in Trevor Weston, editor, The Complete Illustrated Book of Family Health, Toronto: York Press, →ISBN, page 93:

(pharmacology) Synonym of sulfasalazine.


SSZ

(pharmacology) Abbreviation of sulfasalazine.


regular insulin

en-noun

regular insulin (countable and uncountable, plural regular insulins)

(medicine, pharmacology) A type of short-acting medical insulin.


Subutex

Marketing coinage, perhaps based on sublingual (“administered through placement under the tongue”).

He was a Subutex addict. Subutex is supposedly used to wean people off heroin but, from what I have seen, there are more Subutex addicts in jail than there are heroin addicts (and there are a lot of heroin addicts).

2010, Simon Eddisbury, Lowlife, London: John Blake, →ISBN, page 22:

She'd seen a doctor who’d prescribed Subutex, a drug-replacement treatment designed to wean the user off heroin. It had made her throw up. I was so relieved and told her how proud I was of her for taking control.

2013, Mitch Winehouse, Amy, My Daughter, London: Harper, →ISBN, page 120:

(pharmacology) A (now discontinued) brand name for buprenorphine, used to treat opiate addictions.


combination drug

combination drug (plural combination drugs)

(pharmacology) A medicine that includes two or more active ingredients combined in a single dosage form.


controlled-release

(pharmacology) Of a drug or medicine, involving the gradual release of an active component.


tweak freak

LL-Q1860 (eng)-Flame, not lame-tweak freak.wav

From tweak + freak. Chosen for the rhyme.

(slang, derogatory, drugs) A regular user of methamphetamine.


septagliptin

dipeptidyl peptidase-4
dipeptidyl peptidase-4

(pharmacology) A dipeptidyl peptidase-4 inhibitor used as a drug to treat diabetes


glifozin

(pharmacology) A sodium-glucose co-transporter-2 (SGLT2) inhibitor used to treat type-2 diabetes.


Halcion

Halcion (countable and uncountable, plural Halcions)

[…]I'm experiencing a major-league anxiety attack, searching my pockets for Valium, Xanax, a leftover Halcion, anything, and all I find are three faded Nuprin in a Gucci pill-box, so I pop all three into my mouth and swallow them down with a Diet Pepsi and I couldn’t tell you where it came from if my life depended on it.

1991, Bret Easton Ellis, American Psycho, London: Picador, →ISBN, page 148:

(pharmacology) Brand name for triazolam.


Nuprin

Nuprin (countable and uncountable, plural Nuprins or Nuprin)

(pharmacology) Brand name for ibuprofen.


xevinapant

(pharmacology) A drug candidate targeting head and neck cancer.


abortifactive

[…] abortifactive agents such as Brucella abortus and Tritrichomonas foetus are not present in the Swedish bovine population […]

2003, Susanne Stenlund, Hans Kindahl, Arvid Uggla, Camilla Björkman, “A Long-Term Study of Neospora caninum Infection in a Swedish Dairy Herd”, in Acta Veterinaria Scandinavica, volume 44, number 2, pages 63-71:

Complete necropsies, abortion panels to rule out other abortifactive agents, serum Ig levels, and aoEBA-specific immunohistochemistry (IHC) were performed on each fetus to confirm EBA diagnosis.

2011, Roxann S. Brooks, Myra T. Blanchard, Mark L. Anderson, Mark R. Hall, Jeffery L. Stott, “Quantitative duplex TaqMan real-time polymerase chain reaction for the assessment of the etiologic agent of epizootic bovine abortion”, in Journal of Veterinary Diagnostic Investigation, volume 23, number 6, pages 1153-1159:

[…] a high degree of seropositivity to N. caninum was diagnosed after evaluating for various abortifactive agents.

2015, Priya Bapodra, Barbara A Wolfe, “Investigation of Neospora caninum seroprevalence and potential impact on reproductive success in semi-freeranging Père David’s deer (Elaphurus davidianus)”, in Veterinary Record Open, volume 2, number 1:

Abortion panels were conducted to identify fetal/neonatal losses due to other abortifactive agents.

2022, Myra T. Blanchard, Mike B. Teglas, Mark L. Anderson, Peter F. Moore, Bret R. McNabb, Kassidy M. Collins, Bret V. Yeargan, Jeffrey L. Stott, “Protection of Cattle against Epizootic Bovine Abortion (EBA) Using a Live Pajaroellobacter abortibovis Vaccine”, in Vaccines (Basel), volume 10, number 2, page 335:

REMINDER: Steroids may be abortifactive for gravid females; be willing to live by the consequences. Use only in life threatening circumstances for pregnant females.

2024, “Chemical Immobilization, Capture and Handling:”, in Yellowstone Grizzly Project, archived from the original on 2024-08-26:

(pharmacology) Inducing abortion or miscarriage, abortifacient.


angiotensin receptor blocker

angiotensin receptor blocker (plural angiotensin receptor blockers)

renin-angiotensin system
renin-angiotensin system

(medicine, pharmacology) A type of pharmaceutical that binds to and inhibits AT1 and thereby blocks the arteriolar contraction and sodium retention effects of the renin-angiotensin system.


-dronic

From etidronic acid, itself from et(hyl) + (h)ydr(oxy-) + (di-) + (phosph)onic.

af

(pharmacology, organic chemistry) describes derivatives of etidronic acid, used as calcium metabolism regulators


-antel

From anthelmintic (“against parasitic worms”), with simplification of the -nth- and truncation.

(pharmacology) Forms names of anti-worm drugs, often pyrantel derivatives.


cypro

(pharmacology, informal) Clipping of cyproterone.


levacetylleucine

Niemann-Pick disease
Niemann-Pick disease

(pharmacology) A drug for the treatment of neurological manifestations of Niemann-Pick disease type C.


pookie

(slang, drugs) A glass pipe designed for freebasing cocaine, methamphetamine, or other drugs.


glasdegib

(pharmacology) A drug targeting the smoothened protein of the hedgehog signaling pathway, used for the treatment of acute myeloid leukemia.


shermed

(slang, drugs) Under the influence of phencyclidine.


sherm stick

(slang, US, drugs) A cigarette or joint laced with phencyclidine.


SAMA

Coordinate term: LAMA

(pharmacology) Initialism of short-acting muscarinic antagonist.


Lortab

en-proper noun

Lortab (countable and uncountable, plural Lortabs)

After my second day at the Cold Drink, I knew why Misty worked so hard: she was high every night. Lortab, Oxycontin, coke, Ecstasy, meth.

2017, Jesmyn Ward, Sing, Unburied, Sing, Bloomsbury Circus, page 32:

(pharmacology) A brand name for an analgesic combination drug containing hydrocodone and paracetamol, often used for recreational purposes.


clofibric

The last compound, gemfibrozil is the sole antilipidemic compound found (up to 3 ng/L) in a USA survey of 18 DWTPs whereas atorvastatin, simvastatin and their metabolites, the other studied compounds, were absent (Benotti et al., 2009). In our study, the two statins identified at the intake of the DWTP were eliminated by dioxychlorination (>99%) whereas bezafibrate, clofibric acid and gemfibrozil were only moderately removed with percentages of 37%, 68% and 11%, respectively although it has been reported that gemfibrozil and clofibric acid are readily oxidized with chlorine dioxide in spiked drinking water whereas bezafibrate remains unchanged (Huber et al., 2005a).

2011 June 28, Ma Rosa Boleda, Ma Teresa Galceran, Francesc Ventura, “Behavior of pharmaceuticals and drugs of abuse in a drinking water treatment plant (DWTP) using combined conventional and ultrafiltration and reverse osmosis (UF/RO) treatments”, in Environmental Pollution, volume 159, number 6, →DOI, pages 1584-1591:

(pharmacology) Pertaining to clofibrate or clofibric acid.


apatinib

vascular endothelial growth factor
vascular endothelial growth factor

(pharmacology) A tyrosine kinase inhibitor that selectively inhibits the vascular endothelial growth factor receptor-2.


givosiran

(pharmacology) A medication used for the treatment of adults with acute hepatic porphyria.


luspatercept

(pharmacology) A medication used for the treatment of anemia in beta thalassemia and myelodysplastic syndromes.


netupitant

(pharmacology) A particular antiemetic drug.


zanubrutinib

(pharmacology) An anticancer medication used for the treatment of mantle cell lymphoma.


polatuzumab vedotin

diffuse large B-cell lymphoma
diffuse large B-cell lymphoma

(pharmacology) A CD79b-directed antibody-drug conjugate medication used for the treatment of diffuse large B-cell lymphoma.


racotumomab

(pharmacology) A therapeutic cancer vaccine for the treatment of solid tumours.


elexacaftor

(pharmacology) A medication that acts as cystic fibrosis transmembrane conductance regulator corrector.


lirentelimab

(pharmacology) A humanized nonfucosylated monoclonal antibody that targets sialic acid-binding Ig-like lectin 8.


bebtelovimab

(pharmacology) A treatment for COVID-19.


narrow-spectrum

(microbiology, pharmacology) Of an antibiotic, that is only able to kill or inhibit limited species of bacteria.


thermofiltration

Thermofiltration has been used to selectively remove low-density lipoproteins (LDL) in hyperlipidemic patients.

1996, Buddy D. Ratner, editor, Biomaterials Science: An Introduction to Materials in Medicine, illustrated edition, Elsevier, page 409:

When cascade filtration is performed at room temparature, plasme in the secondary filter reaches a temperature of around 30℃. In thermofiltration the secondary filter is warmed up to a physiologic temperature (37℃, sometimes up to 42℃).

2013, Walter H. Hörl, Karl-Martin Koch, Robert M. Lindsay, C. Ronco, J.F. Winchester, editors, Replacement of Renal Function by Dialysis, 5, illustrated edition, Springer Science & Business Media, page 718:

(medicine, pharmacology) A process that combines heat (thermal treatment) and filtration to remove or deactivate microorganisms, particles, or contaminants from liquids, particularly in industries such as food processing, pharmaceuticals, and water purification.