"histotope" meaning in English

{
  "etymology_templates": [
    {
      "args": {
        "1": "en",
        "2": "histo",
        "3": "tope"
      },
      "expansion": "histo- + -tope",
      "name": "confix"
    }
  ],
  "etymology_text": "histo- + -tope",
  "forms": [
    {
      "form": "histotopes",
      "tags": [
        "plural"
      ]
    }
  ],
  "head_templates": [
    {
      "args": {},
      "expansion": "histotope (plural histotopes)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        {
          "kind": "other",
          "name": "English entries with incorrect language header",
          "parents": [
            "Entries with incorrect language header",
            "Entry maintenance"
          ],
          "source": "w"
        },
        {
          "kind": "other",
          "name": "English terms prefixed with histo-",
          "parents": [],
          "source": "w"
        },
        {
          "kind": "other",
          "name": "English terms suffixed with -tope",
          "parents": [],
          "source": "w"
        }
      ],
      "examples": [
        {
          "ref": "1984, William E. Paul, Immunogenetics, page 156",
          "text": "Thus, a mutation affecting the structure of a class II molecule changes the co-recognition specificity of a histotope on the APC of the mutant.",
          "type": "quotation"
        },
        {
          "ref": "2012, Benvenuto Pernis, Processing and Presentation of Antigens, page 117",
          "text": "However, this experiment by itself did not distinguish whether the change was in the desetope, which is the most straightforward interpretation, or in the histotope.",
          "type": "quotation"
        },
        {
          "ref": "2012, Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Ir Genes: Past, Present, and Future, page 303",
          "text": "First, during ontogeny, T cells are positively selected by recognition of the histotope and then negatively selected by a tolerance mechanism or vice versa.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "The portion of an antigen that reacts with or binds to a T-cell."
      ],
      "id": "en-histotope-en-noun-yQuiEaKd",
      "links": [
        [
          "antigen",
          "antigen"
        ],
        [
          "react",
          "react"
        ],
        [
          "bind",
          "bind"
        ],
        [
          "T-cell",
          "T-cell"
        ]
      ],
      "related": [
        {
          "word": "agretope"
        },
        {
          "word": "allotope"
        },
        {
          "word": "desetope"
        },
        {
          "word": "epitope"
        },
        {
          "word": "glycotope"
        },
        {
          "word": "histotype"
        },
        {
          "word": "idiotope"
        },
        {
          "word": "paratope"
        },
        {
          "word": "supertope"
        }
      ]
    }
  ],
  "word": "histotope"
}

{
  "etymology_templates": [
    {
      "args": {
        "1": "en",
        "2": "histo",
        "3": "tope"
      },
      "expansion": "histo- + -tope",
      "name": "confix"
    }
  ],
  "etymology_text": "histo- + -tope",
  "forms": [
    {
      "form": "histotopes",
      "tags": [
        "plural"
      ]
    }
  ],
  "head_templates": [
    {
      "args": {},
      "expansion": "histotope (plural histotopes)",
      "name": "en-noun"
    }
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "related": [
    {
      "word": "agretope"
    },
    {
      "word": "allotope"
    },
    {
      "word": "desetope"
    },
    {
      "word": "epitope"
    },
    {
      "word": "glycotope"
    },
    {
      "word": "histotype"
    },
    {
      "word": "idiotope"
    },
    {
      "word": "paratope"
    },
    {
      "word": "supertope"
    }
  ],
  "senses": [
    {
      "categories": [
        "English countable nouns",
        "English entries with incorrect language header",
        "English lemmas",
        "English nouns",
        "English terms prefixed with histo-",
        "English terms suffixed with -tope",
        "English terms with quotations"
      ],
      "examples": [
        {
          "ref": "1984, William E. Paul, Immunogenetics, page 156",
          "text": "Thus, a mutation affecting the structure of a class II molecule changes the co-recognition specificity of a histotope on the APC of the mutant.",
          "type": "quotation"
        },
        {
          "ref": "2012, Benvenuto Pernis, Processing and Presentation of Antigens, page 117",
          "text": "However, this experiment by itself did not distinguish whether the change was in the desetope, which is the most straightforward interpretation, or in the histotope.",
          "type": "quotation"
        },
        {
          "ref": "2012, Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Ir Genes: Past, Present, and Future, page 303",
          "text": "First, during ontogeny, T cells are positively selected by recognition of the histotope and then negatively selected by a tolerance mechanism or vice versa.",
          "type": "quotation"
        }
      ],
      "glosses": [
        "The portion of an antigen that reacts with or binds to a T-cell."
      ],
      "links": [
        [
          "antigen",
          "antigen"
        ],
        [
          "react",
          "react"
        ],
        [
          "bind",
          "bind"
        ],
        [
          "T-cell",
          "T-cell"
        ]
      ]
    }
  ],
  "word": "histotope"
}