drugsploitation

Meanwhile, newfangled drugsploitation flicks like Maryjane and The Hooked Generation invaded drive-ins, providing cautionary tales while the smell of those funny scented cigarettes filled the night air.

2004, Irv Slifkin, VideoHound's Groovy Movies: Far-out Films of the Psychedelic Era, Visible Ink Press, →ISBN, page 201:

Such shots are to be found throughout the genre from early 'drug hysteria' and 'drugsploitation' movies through to its most recent examples.

2006, David Boothroyd, Culture on Drugs: Narco-cultural Studies of High Modernity, Manchester University Press, →ISBN:

Fonda persuaded director Roger Corman to hire the band for his drugsploitation movie The Trip, a paean to LSD scripted by Jack Nicholson.

2006, Barney Hoskyns, Hotel California: The True-Life Adventures of Crosby, Stills, Nash, Young, Mitchell, Taylor, Browne, Ronstadt, Geffen, the Eagles, and Their Many Friends, Wiley, →ISBN, page 61:

(film) A genre of exploitation films which focus on the use of recreational drugs, typically featuring lurid scenes of drug-induced behaviour framed as a cautionary tale/morality play.


antiasthenic

en-adj

antiasthenic (comparative more antiasthenic, superlative most antiasthenic)

more antiasthenic (comparative)
most antiasthenic (superlative)


NAC

(pharmacology) Abbreviation of N-acetylcysteine.


sulphasalazine

en-noun

sulphasalazine (countable and uncountable, plural sulphasalazines)

(British spelling, pharmacology) Alternative form of sulfasalazine


near beer

near beer (countable and uncountable, plural near beers)

That which we now have, and called near beer, with less than a half per cent of alcohol, is not drinkable, it is not palatable, it is not good, it is no part of a meal, nor can it be made a part of a meal.

1924, “Proposed Modification of the Prohibition Law to Permit the Manufacture, Sale and Use of 2.75 Per Cent Beverages: Hearing Before the Committee on the Judiciary, House of Representatives, Sixty-eighth Congress, First Session”, in Barrel and Box and Packages, volume 21:

Maybe that near beer was nearer than he thought.

2016, "Lawmakers wade into debate over grocery store beer," Kristen Wyatt, Associated Press
A bill moving through the state Legislature would allow more grocery stores to sell beer stronger than 3.2 percent alcohol, or “near beer.”

Any of a class of malt liquors that contain so little alcohol (usually less than 0.5%) that they will not produce intoxication.


light-struck

en-adj

light-struck (comparative more light-struck, superlative most light-struck)

more light-struck (comparative)
most light-struck (superlative)

From light (noun) + struck (participial adjective).

affix

(of beer) Spoiled by exposure to light, which causes riboflavin to catalyze a chemical process ultimately producing a thiol (MBT) from isohumulone.


neuropharmacologically

en-adv

neuropharmacologically (comparative more neuropharmacologically, superlative most neuropharmacologically)

more neuropharmacologically (comparative)
most neuropharmacologically (superlative)

(pharmacology) In a neuropharmacological manner; with regard to neuropharmacology.


nastoyka

A Slavic liqueur containing an infusion of herbs and/or fruits in brandy or similar spirit

насто́йка

a Slavic liqueur containing an infusion of herbs and/or fruits in brandy or similar spirit


tepache

en-noun

tepache (countable and uncountable, plural tepaches)

Borrowed from Spanish tepache, from Nahuatl tépiatl or Nahuatl tepachoa.

A fermented beverage, sometimes alcoholic, made from the peel and the rind of pineapples, which is sweetened with either piloncillo or brown sugar, seasoned with powdered cinnamon, and served cold.


antipseudomonal

antipseudomonal antibiotic ear drops

(pharmacology) Countering pseudomonad bacteria


top fermentation

Carlton was mainly equipped to produce top-fermentation bulk beer, the old fashioned English ale. But the public taste had changed. On 27 April the brewers reported to the board that the public taste now was largely for bottom-fermentation beer or lager.

1987, Keith Dunstan, The Amber Nectar, Ringwood: Vicking O'Neil, page 90:

Top fermentation is usually carried out at between 64 and 77 ° F/ 18– 25 ° C and takes two to seven days, during which the yeasty foam is skimmed off several times.

2004, Harold McGee, chapter 13, in On Food and Cooking: The Science and Lore of the Kitchen, Scribner, →ISBN:

(brewing) Alcoholic fermentation during which the yeast cells are carried to the top of the fermenting liquid.


liquid sunshine

"He has found that the rays do not penetrate fluorescent fluids, or liquid sunshine as they are sometimes called.

1904, The Medical Standard - Volume 27, page 339:

In the meantime save that thirst to quench it in LIQUID SUNSHINE.

1919, The Northwestern Druggist: A Progressive Journal for Retail Druggists, Volume 27, page 145:

Five glasses a day of what was known as liquid sunshine would 'increase your income by keeping you and your family fit.

2010, Rose Shapiro, Suckers: How Alternative Medicine Makes Fools of Us All, →ISBN, page 111:

A beverage that is fluorescent or irradiated, believed to have medicinal properties.

He left a bad taste in my mind, let me have another good gulp of this liquid sunshine here with my bird's wing.

1990, Thomas Mann, Lotte in Weimar: The Beloved Returns, →ISBN, page 351:

The wine was worthy to be celebrated in classic verse; none so good is, I am sure, made elsewhere in Syria ; it was liquid sunshine; and as it was manufactured by the monks, it gave us a new respect for their fastidious taste.

2002, Charles Dudley Warner, In the Levant - Volume 1, →ISBN, pages 199–200:

Even if it was liquid sunshine it would've tasted like piss, the situation I'm in.

2007, Torsten Krol, Callisto, →ISBN, page 314:

An alcoholic beverage that is particularly smooth and tasty.

So it was out and away to the road, place the call, punch a bunch of buttons ("To transfer funds, Press 9") in the liquid sunshine, while adjusting an umbrella to improve reception.

2008, Lynne Farr, Off the Grid Without a Paddle, →ISBN, page 39:

I'm in my tent on the shores of the beautiful Pacific, listening to the plentiful supply of liquid sunshine coming down.

2009, Frederick E. LaCroix, The Sky Rained Heroes: A Journey from War to Remembrance, →ISBN, page 205:

“You certainly would," Amber said, “if the builder hadn't taken our liquid sunshine into account." She pushed a switch on the outside wall. A clear plastic building began to unfold onto the arbor's structure.

2010, Stephen Arterburn, Mike Moscoe, The Forsaken, →ISBN, page 91:


gallize

en-verb

gallize (third-person singular simple present gallizes, present participle gallizing, simple past and past participle gallized)

term-label

(American spelling, Oxford British English)

gallizes (present singular third-person)
gallizing (participle present)
gallized (participle past)
gallized (past)

From German Gall + English -ize (suffix forming verbs from adjectives or nouns with the sense of doing what the adjective or noun denotes), from the surname of Dr. Ludwig Gall (1791–1863), the German inventor who developed the process.

refn

From Illustrirter Kalender für 1860: Jahrbuch der Ereignisse Bestrebungen und Fortschritte im Völkerleben und im Gebiete der Wissenschaften Künste und Gewerbe [Illustrated Calendar for 1860: Yearbook of Events, Efforts and Advances in People’s Lives and in the Fields of Science, Arts and Commerce], volume XV, Leipzig: J. J. Weber, 1860, →OCLC, page 68.

[page 163] Therefore it is, that to us the knowledge of how to properly gallize our wines is still more important than to the European vintner, and the results which we can realize are yet more important. [...] [page 172] Truth and justice need never fear the light—they can only gain additional force from it. I do not even attempt to sell a cask of gallized wine, before the purchaser is made fully acquainted with the fact, that it has been gallized.

1866, George Husmann, “Wine-making”, in The Cultivation of the Native Grape, and Manufacture of American Wines, New York, N.Y.: Geo[rge] E. Woodward, […], →OCLC, pages 163 and 172:

The demand for native wines has diminished of late considerably, and their sale rendered difficult; and, although other causes may, in part, account for this, one of them, not to be overlooked, will be found in the prejudice which has been created against them by the public discussion of the propriety of gallizing our wine, and which has furnished a weapon to the hands of the importers of foreign wines, which they have wielded and still wield with great effect against the use of our native produce.

1867 January 8, “[Proceedings of the Missouri Horticultural Society.] Observations in Theodore Engelmann’s Vineyard, St. Clair County, Illinois, 1866.”, in Second Annual Report of the Missouri State Board of Agriculture, […] for the Year 1866, Jefferson City, Mo.: Emory S. Foster, […], →OCLC, page 385:

As a wine grape its unequaled bouquet is the principal recommendation. It is deficient in sugar, and the juice is usually gallized, fortified by the addition of alcohol, or otherwise manipulated.

1870, “Report of the Superintendent of Gardens and Grounds”, in Report of the Commissioner of Agriculture for the Year 1869, Washington, D.C.: Government Printing Office, →OCLC, page 86:

At the South Carolina State Fair, held at Columbia, wines were exhibited from other grapes made by the same process, with this difference—that some of them were not Gallized, and no sugar added.

1871 February, R. D’Hereuse, “D’Hereuse’s Patent Air Treatment”, in W[illia]m and W. L. Jones, editors, Southern Cultivator: A Practical and Scientific Magazine, for the Plantation, the Garden and the Family Circle, volume XXIX, number 2, Athens, Ga.: Wm. and W. L. Jones, →OCLC, page 69, column 1:

I weigh the must by Oechsle's must scale, and add white sugar to it until it weighs 100 degrees, then I gallise it by one-fourth of water in which sugar is dissolved to the same standard of the must.

1875, Henry Funk, “[Statements of Exhibiters.] Statement of Henry Funk—Wine.”, in A. M. Garland, editor, Transactions of the Department of Agriculture of the State of Illinois. […] for the Year 1874, volume IV (New Series; volume XII overall), Springfield, Ill.: State Journal Steam Plant, →OCLC, page 68:

Potato-sugar contains impurities of sulphuric acid, iron sulphate, and lime. [...] Wines "gallised" with potato-sugar are consequently pro tanto poisonous, and the use of such sugars in brewing becomes a matter of questionable permissibility.

1881 October 14, “Chemical Notices from Foreign Sources. [Biedermann’s Central-Blatt für Agrikultur-Chemie, Vol. X, No. I. The Injurious Action of Potato-Sugar.]”, in William Crookes, editor, The Chemical News and Journal of Physical Science. […], volume XLIV, number 1142, London: […] Edwin John Davey, […], →OCLC, page 192, column 2:

All wine, Moselle and Necktar wines—in fact, all German wines shipped to America—are gallized, and exactly this circumstance has created a very important market in America for these wines.

1916, J. Beyse, “K. A. Hellenthal’s Manual for Wine Growers and Wine Dealers, or The Perfect Wine Cellar Master. Eighth Improved and Enlarged Edition. […]”, in Ottmar G. Stark, transl., To Increase the Revenue: Hearings before the Subcommittee of the Committee on Finance, United States Senate, Sixty-fourth Congress, First Session, on H.R. 16763, an Act to Increase the Revenue, and for Other Purposes […], part 1 (Sections Relating to Wines and Liqueurs, Dyestuffs, Drugs and Coal-tar Products, and Munition Manufacturers’ Tax), Washington, D.C.: Government Printing Office, →OCLC, page 62:

(transitive, winemaking, dated) To add sugar and water to (unfermented grape juice) so as to increase the quantity of wine produced.

gallisieren

to add sugar and water to (unfermented grape juice) so as to increase the quantity of wine produced


quarantini

Now she is planning to host weekly video chat happy hours to help moms “celebrate surviving another week of the Coronapocalypse” with a “quarantini.”

2020 March 21, Alanna Durkin Richer, quoting Emily Anderson, “Quarantini? Happy hours go virtual”, in Telegraph-Herald, Dubuque, Iowa, page C7:

What, exactly, is a quarantini other than something you drink during a quarantine? There are plenty of recipes floating around online, such as basic vodka martinis sipped from your sofa or more elaborate concoctions that add in items like emergen-c.

2020 March 31, “How to make a ‘quarantini’”, in The Province, Vancouver, BC, page A22:

MacKillop says the data are still being compiled and analyzed, but he won't be surprised if, at the end of the day, we learn that alcohol consumption in Ontario was lower during the pandemic. Among many populations in Europe, similar patterns are emerging.
So why did everyone take up the quarantini bender story as objective truth?

2021 July 6, “‘Quarantini problem’ may have been a myth”, in Toronto Star, page B9:

Recipes included things like "Fau-Cheesy Rice and Broccoli," "Peas Make-the-Corona-Virus-Go-Away Salad," and "Dirty Quarantini." Do you have a favorite?

2021 July 20, Randy Petersen, “Lake City’s Dick Boerger has recipe for success in Wall Street Journal”, in Post-Bulletin, Chicago:

(humorous, neologism) A martini-style cocktail popular amongst people in COVID-19 lockdown.


chasse-café

/ˌʃæskæˈfeɪ/

Borrowed from French chasse-café (literally “coffee-chaser”).

bor

"[…] And here comes tea and coffee—may as well have some, I suppose it will be all the same price. And what's this?" eyeing a lot of liqueur glasses full of eau de vie. "Chasse café, Monsieur," said the garçon. "Chasse cafe—chasse cafe—what's that? Oh, I twig—what we call 'shove in the mouth' at the Free-and-Easy.—Yes, certainly, give me a glass."

1833 May, “a Yorkshireman” [pseudonym], “A Trip to Paris with Mr. Jorrocks”, in The New Sporting Magazine, volume V, number XXV, London: Baldwin & Cradock [et al.], →OCLC, page 42:

The business of the drama is now over, and by way of epilogue, you toss off a demi-tasse of café noir, with its accompanying petit verre de liqueur, which has been appositely termed chasse-café, from the peculiar rapidity it usually exhibits in following that aromatic beverage. […] Such are the details of a Parsian dinner; […]

1838, [Hezekiah Hartley Wright], chapter XXI, in Desultory Reminiscences of a Tour through Germany, Switzerland, and France. By an American, Boston, Mass.: William D[avis] Ticknor; Philadelphia, Pa.: E[dward] L. Carey and A[braham] Hart, →OCLC, page 297:

The former will have devoted himself to you for the first half-score hours, have promenaded, dined à la carte, and chasse café’d with you, seen you to your hotel with bows, promises, and ravishing language, and then—have forgotten you for ever.

[1847, Sylvanus [pseudonym; Robert Colton], “Letter XIX”, in Rambles in Sweden and Gottland: With Etchings by the Way-side, London: Richard Bentley, […], →OCLC, page 131:

The dinner was in the best French manner—choice fruit, and wines of the greatest variety and richness; melon, with boiled beef as usual; coffee after dinner, without cream, and a small glass of liqueur called chasse-café, after it.

1853, James Simpson, “The Louvre Gallery—First Visit”, in Paris after Waterloo: Notes Taken at the Time and hitherto Unpublished: […], Edinburgh, London: William Blackwood and Sons, →OCLC, page 143:

Sir Louis began by ordering the woman to bring him chasse-café. She offered him coffee, as much as he would; but no chasse.

1858, Anthony Trollope, “Sir Louis Leaves Greshamsbury”, in Doctor Thorne. […], volume III, London: Chapman & Hall, […], →OCLC, page 118:

I could not understand why they gave us unlimited light claret for dinner, with Madeira and champagne, with any number of chasse cafés, all included in the passage-money, whilst any one calling for a modest glass of ale had to pay extra, and pretty handsomely, for the same.

1868, H[enry] C[harles] Ross Johnson, “The Conspiracy.—The Harbour of Buenos Ayres.”, in A Long Vacation in the Argentine Alps: Or Where to Settle in the River Plate States, London: Richard Bentley, […], →OCLC, page 22:

At the concert (which was at three) I found [Anton] Rubinstein who is here visiting his wife for Christmas. We dined together (at the Grand Hôtel de Russie, Babuino). As a chasse-café I banged out for him my arrangement of the Tic-tac Tarantelle by [Alexander] Dargomizhsky.

1880 January 3, Franz Liszt, “1880 [chapter title]”, in William R[oyall] Tyler, transl., The Letters of Franz Liszt to Olga von Meyendorff 1871–1886 in the Mildred Bliss Collection at Dumbarton Oaks, Washington, D.C.: Dumbarton Oaks; trustees for Harvard University, published 1979, →ISBN, page 365:

(dated) A small serving of spirits taken to remove the taste of coffee, tobacco, etc.


samshu

An irregular romanization of the Cantonese pronunciation saam¹ siu¹ of 三燒／三烧 (sānshāo, “thrice-burnt”), a former name of 三蒸酒 (sānzhēngjiǔ, “thrice-distilled alcohol”).

(inexact, obsolete or historical) Synonym of baijiu.


Liebfraumilch

From German Liebfrauenmilch, literally "beloved Lady's milk", referring to the Liebfrauenkirche (the Church of Our Lady) in Worms, Germany, near which the wine was originally produced.

He took a seat and poured himself a big glass of Liebfraumilch instead.

2000, Zadie Smith, White Teeth, London: Penguin Books, published 2001, →ISBN, page 22:


antivenomous

en-adj

antivenomous (comparative more antivenomous, superlative most antivenomous)

more antivenomous (comparative)
most antivenomous (superlative)

(pharmacology, immunology) acting against venom


olivomycin

From translingual olivo(reticuli) + -mycin (“antibiotic”).

af

(pharmacology) Any of a class of glycosidic antibiotics obtained from Actinomyces olivoreticuli.


vosoritide

From [Term?] + -ritide (“natriuretic peptide”).

It is too soon to say if vosoritide can prevent any of those complications.

2015 June 17, Andrew Pollack, “Drug Accelerated Growth in Children With Dwarfism, Pharmaceutical Firm Says”, in New York Times:

(pharmacology) A drug used to treat dwarfism.


rufinamide

Rufinamide is a triazole derivative structurally unrelated to any currently marketed AED.

2007, C. P. Panayiotopoulos, A Clinical Guide to Epileptic Syndromes and Their Treatment, →ISBN, page 530:

Rufinamide exhibits its anticonvulsant effects through limiting neuronal sodium-dependent action potential firing.

2010, Neonatal and Pediatric Pharmacology: Therapeutic ..., →ISBN, page 547:

(pharmacology) A triazole derivative used as an anticonvulsant


minitablet

In these, highly active enteric-coated granules, pellets, or minitablets are to be found in gelatin capsules which disintegrate rapidly (2-3 min) in the stomach regardless of the pH.

1991, G.J. Peschke, “Active components and galenic aspects of enzyme preparations”, in Pancreatic Enzymes in Health and Disease, →DOI:

Minitablets refer to tablets with a diameter of 2-3 mm.

2011, Hong Wen, Kinam Park, Oral Controlled Release Formulation Design and Drug Delivery, →ISBN, page 119:

Recently, a delayed-release capsule containing enteric-coated minitablets of fenofibric acid (Triplex) has been commercialized.

2013, Antoine Al-Achi, Integrated Pharmaceutics, →ISBN:

(pharmacy) A small tablet having a diameter of less than 3 millimeters


sofosbuvir

From [Term?] + -fos- (“phosphorous derivative”) + -buvir (“RNA polymerase (NS5B) inhibitor”).

Sofosbuvir does not affect cyclosporine or tacrolimus concentrations.

2013, Marina Berenguer, Hepatitis C Virus and Liver Transplantation, →ISBN, page 57:

In the US, sofosbuvir and simeprevir have been approved for the treatment of chronic hepatitis C.

2015, Nicholas J Talley, Essentials of Internal Medicine 3e, →ISBN, page 382:

(pharmacology) A nucleotide analog used in combination with other drugs for the treatment of hepatitis C.


biostable

en-adj

biostable (comparative more biostable, superlative most biostable)

more biostable (comparative)
most biostable (superlative)

Based on their behavior in living tissue, polymeric biomaterials can be divided into biostable, bioabsorbable (biodegradable or bioresorbable), and partially bioabsorbable materials.

2001, Polymeric Biomaterials, Revised and Expanded, →ISBN, page 545:

In these cases, a high molecular weight, biostable polymeric carrier is preferred.

2003, Vasant V. Ranade, Drug Delivery Systems, Second Edition, →ISBN, page 84:

Here, we have focused the attention on PMMA because this polymer is considered a biostable polymer in biomedical applications.

2006, Kimberly S. Gehar, Nanophysics, Nanoclusters and Nanodevices, →ISBN, page 24:

(pharmacy) Remaining chemically stable within the body


tonicify

en-verb

tonicify (third-person singular simple present tonicifies, present participle tonicifying, simple past and past participle tonicified)

tonicifies (present singular third-person)
tonicifying (participle present)
tonicified (participle past)
tonicified (past)

The study consisted of a screening design evaluating protein, buffer, tonicifying agent, cryoprotectant, surfactant, and pH levels.

2010, Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals, →ISBN, page 168:

A non-ionic tonicifying agent is incorporated into the pharmaceutical compositions to render the compositions isotonic[…].

2013, Multiple Sclerosis, →ISBN, page 438:

(pharmacy) To increase the tonicity of a solution


pelinkovac

From Serbo-Croatian pelinkovac, from pelin (“wormwood”).

Absinthe tastes and smells like a cross between ouzo and pelinkovac.

1988 July 8, Victor A. Friedman, “Improvising Absinthe”, in Chicago Reader:

His gaze fell on a bottle of pelinkovac and his stomach lurched.

2008, Coral Petkovich, Ivan, from Adriatic to Pacific, →ISBN, page 75:

A liqueur made from wormwood, originating in the Balkans.


fernet

en-noun

fernet (usually uncountable, plural fernets)

From Italian fernet, of uncertain origin.

But few in Córdoba think fernet and Coke, like the city itself, will lose its edge.

2015 June 30, Jonathan Gilbert, “Argentine City Aims to Stand Out With Rebellious Spirit (and Coke) in a Cup”, in New York Times:


gevokizumab

From [Term?] + -ki- (“interleukin”) + -zumab (“humanized monoclonal antibody”).

af

(pharmacology) A particular monoclonal antibody.


ulipristal

From uli- (of unknown origin) + (mife)prist(one) + a(cety)l.

(pharmacology) A selective progesterone receptor modulator used in the acetate form for emergency contraception and to treat uterine fibroids.


weissburgunder

The Germanic leitmotif found throughout Alto Adige (a k a South Tyrol) emerges in Tiefenbrunner’s stylish 2005 pinot bianco, also labeled weissburgunder.

2007 January 21, Howard G. Goldberg, “Italian by Birth, German in Style”, in New York Times:

A dry white wine from Germany and Austria


Sancerre

Centre-Val de Loire
Centre-Val de Loire#English

A commune and canton in the eastern part of the Loire valley in Centre-Val de Loire, France.


glinide

(organic chemistry, pharmacology) Contraction of meglitinide.


fondaparinux

From fonda- (of unknown origin) + -parinux (“synthetic heparinoid”).

Moreover, we provide here additional positive experience in the treatment of both, CVT and HIT, by fondaparinux with bridging to warfarin given their successful evolution under this anticoagulant option.

2013 July 9, J Hsieh et al., “Cerebral venous thrombosis due to cryptogenic organising pneumopathy with antiphospholipid syndrome worsened by heparin-induced thrombocytopenia”, in BMJ Case Reports, volume 2013, →DOI:

(pharmacology) An anticoagulant medication chemically related to low-molecular-weight heparins.


antilipolytic

en-adj

antilipolytic (comparative more antilipolytic, superlative most antilipolytic)

more antilipolytic (comparative)
most antilipolytic (superlative)

GPR81 is expressed primarily in adipocytes and have^([sic]) an antilipolytic effect (Liu et al., 2009).

2015 June 19, Graciela L. Garrote, Analía G. Abraham, Martín Rumbo, “Is lactate an undervalued functional component of fermented food products?”, in Frontiers in Microbiology, volume 6, →DOI:


parecoxib

All patients also received 1 g IV paracetamol, 1.5 mg/kg IV tramadol and 40 mg IV parecoxib analgesia intraoperatively, as well as pre-emptive antiemesis of 8 mg IV dexamethasone and 1 mg IV granisetron.

2015 July 2, Chong Oon Tan et al., “Surgical predictors of acute postoperative pain after hip arthroscopy”, in BMC Anesthesiology, volume 15, →DOI:

(pharmacology) A water-soluble and injectable prodrug of valdecoxib.


ertapenem

(organic chemistry, pharmacology) A particular carbapenem antibiotic, structurally similar to meropenem.


antianabolic

(pharmacology) That inhibit anabolic functions (such as tissue formation)


anticytotoxic

Another option exists for eliminating Tregs is anticytotoxic T-lymphocyte antigen 4 (CTLA4) antibodies.

2015 June 17, Liu Yang et al., “Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme”, in BioMed Research International, volume 2015, →DOI:

(toxicology, pharmacology) Acting against cytotoxic effects.


antiestrogenic

Tamoxifen, a nonsteroidal antiestrogenic agent, is used widely as adjunctive therapy for women with breast cancer.

2015, Alka Jindal et al., “Endometrial evaluation by ultrasonography, hysteroscopy and histopathology in cases of breast carcinoma on Tamoxifen therapy”, in Journal of Mid-Life Health, volume 6, →DOI:


ganitumab

From -tu- (“tumor”) + -umab (“human monoclonal antibody”).

af

While a randomized Phase II study testing the addition of the IGF1R mab ganitumab to chemotherapy in EWS is ongoing (NCT02306161), CAR T cells targeting IGF1R may be an alternative treatment for high risk patients with EWS and other sarcomas.

2015 July 15, “IGF1R- and ROR1-Specific CAR T Cells as a Potential Therapy for High Risk Sarcomas”, in PLOS ONE, →DOI:

(pharmacology) A human monoclonal antibody against type 1 insulin-like growth factor receptor, designed for the treatment of cancers.


ledipasvir

From [Term?] + -asvir (“hepatitis C virus NS5A inhibitor”).

(pharmacology) A particular drug for the treatment of hepatitis C.


enzalutamide

From (b)enza(mide) + -lutamide (“nonsteroid antiandrogen”).

Abiraterone and enzalutamide are newly approved drugs for CRPC patients; although, patients will still eventually relapse and the overall survival is prolonged only ~4–5 months after treatment with the AR signaling becoming active in most of these relapsed tumors.

2015 July 16, “Poly (A) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor”, in PLOS ONE, →DOI:

(pharmacology) A synthetic, non-steroidal pure antiandrogen developed for the treatment of metastatic castration-resistant prostate cancer.


freeze distillation

The process of enriching a solution (not truly distilling it) by partially freezing it and then removing frozen material that is poorer in the dissolved material than is the liquid portion left behind.


aducanumab

From -n- (“neural”) + -umab (“human monoclonal antibody”).

Biogen’s drug, aducanumab, slowed the decline in cognition in an early-stage trial.

2015 July 19, The New York Times, “Greece’s Debt Payments, Apple Earnings and Credit Suisse Results”, in New York Times:

(pharmacology) A human monoclonal antibody and drug candidate designed for treatment of Alzheimer's disease.


antilipemic

en-adj

antilipemic (comparative more antilipemic, superlative most antilipemic)

more antilipemic (comparative)
most antilipemic (superlative)

Conversely, peak blood concentration is comparable to the highest evaluated affinity for the antibacterial norfloxacin, and higher than this threshold for the three antilipemic medications pravastatin, fluvastatin and atorvastatin.

2015 July 14, “All-Purpose Containers? Lipid-Binding Protein – Drug Interactions”, in PLOS ONE, →DOI:

(pharmacology) That lowers the amount of lipid in the blood

antilipemico

that lowers the amount of lipid in the blood


nivolumab

From -l- (“immunomodulating”) + -umab (“human monoclonal antibody”).

af

checkpoint inhibitor
checkpoint inhibitor

(pharmacology) a human IgG4 anti-PD-1 monoclonal antibody, acting as a checkpoint inhibitor, thus allowing activated T cells to attack cancer cells


paritaprevir

From [Term?] + -previr (“hepatitis C virus protease inhibitor”).

(pharmacology) An acylsulfonamide inhibitor of the NS3-4A serine protease, under investigation for the treatment of hepatitis C.


mometasone

From [Term?] + -metasone (“prednisone or prednisolone derivative”).

The ICS formulations reported in the trials included beclometasone, budesonide, ciclesonide, flunisolide, fluticasone, and mometasone.

2015 July 21, “Impact of Inhaled Corticosteroids on Growth in Children with Asthma: Systematic Review and Meta-Analysis”, in PLOS ONE, →DOI:

(pharmacology) A glucocorticosteroid drug used topically in the furoate form to reduce inflammation.


obinutuzumab

From [Term?] + -tu- (“tumor”) + -zumab (“humanized monoclonal antibody”).

Recently, mogamulizumab (anti-CCR4 antibody, Kyowa Hakko Kirin) and obinutuzumab (anti-CD20 antibody, Genentech/Roche) with depleted core fucoses have been approved for marketing, and several glycoengineered antibodies are in clinical studies and are being developed as next generation therapeutic monoclonal antibodies.

2015 July 23, “Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities”, in PLOS ONE, →DOI:


ombitasvir

(pharmacology) A particular antiviral drug for the treatment of hepatitis C virus.


zibotentan

From [Term?] + -entan (“endothelin receptor antagonist”).

The indirect comparisons showed that there were no significant differences between zibotentan plus docetaxel versus atrasentan plus docetaxel when compared with docetaxel alone or zibotentan versus atrasenta compared with placebo in the improvement of PFS, OS, TTP, and total adverse events.

2015 July 21, “A Meta-Analysis and Indirect Comparison of Endothelin A Receptor Antagonist for Castration-Resistant Prostate Cancer”, in PLOS ONE, →DOI:

(pharmacology) An endothelin receptor antagonist under investigation as an anticancer drug.


methylthioninium

From methyl + thionine + -ium (“quaternary ammonium compound”).

Methylene blue (MB, methylthioninium chloride) is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler.

2014 February 20, Cliona Stack et al., “Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity”, in Human Molecular Genetics, volume 23, →DOI:

(organic chemistry, pharmacology) The heterocyclic cation 3,7-bis(dimethylamino)-phenothiazin-5-ium, which is the basis of methylene blue


antiglaucomatous

Noteworthy, the ocular hypotensive effect promoted by D+I did not interfere in the MAP. This characteristic is desirable for any antiglaucomatous drug or formulation as it increases its specificity reducing potential side effects.

2015 July 24, “Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats”, in PLOS ONE, →DOI:


antichlamydial

Although we cannot exclude that inter-clone recombination may have also contributed to this notable frequency increase, values of this magnitude were only previously observed under strong selective pressures with antichlamydial compounds [137 ].

2015 July 25, “Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors”, in PLOS ONE, →DOI:

(pharmacology) Acting against chlamydia.


therapeutic use exemption

en-noun

therapeutic use exemption (plural therapeutic use exemptions)

(sports pharmacology) An exemption which allows the use of a banned substance for therapeutic purposes so that a ban from competition will not result when testing yields a positive results.


TUE

therapeutic use exemption
therapeutic use exemption#English

(sports pharmacology) Initialism of therapeutic use exemption.


evolocumab

From [Term?] + -c- (“cardiovascular”) + -umab (“human monoclonal antibody”).

af

So was Repatha, or evolocumab, a similar drug developed by Amgen that is expected to win F.D.A. approval by the end of August.

2015 July 24, Andrew Pollack, “New Drug Sharply Lowers Cholesterol, but It’s Costly”, in New York Times:

(pharmacology) A human monoclonal antibody designed for the treatment of hyperlipidemia.


rilpivirine

From [Term?] + -virine (“nonnucleoside reverse transcriptase inhibitor”).

In this paper, we excluded the HIV infected patients taking indinavir, didanosine or rilpivirine as the initial regimen for cART.

2015 July 25, “Reasons and Risk Factors for the Initial Regimen Modification in Chinese Treatment-Naïve Patients with HIV Infection: A Retrospective Cohort Analysis”, in PLOS ONE, →DOI:

(pharmacology) A drug used to treat HIV infection.


alirocumab

/ˌæl.ɪˈɹɑk.jəˌmæb/

Praluent, also known as alirocumab, was endorsed last month by outside advisers to the Food and Drug Administration .

(pharmacology) A human monoclonal antibody used to treat high cholesterol.


galeterone

From [Term?] + -terone (“antiandrogen”).

(pharmacology) A steroidal antiandrogen under development for the treatment of prostate cancer.


etoricoxib

From etori- (of unknown origin) + -coxib (“cyclo-oxygenase inhibitor”).

A selective COX-2 inhibitor, etoricoxib, was reported to reduce the expression of NF-κB protein and inhibit DMH-induced colon ACF in rats.

2015 July 14, Li Zhang, Handong Wang, Orazio Taglialatela-Scafati, “Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin”, in Marine Drugs, volume 13, →DOI:

nonsteroidal anti-inflammatory drug
nonsteroidal anti-inflammatory drug

(pharmacology) A synthetic, nonsteroidal anti-inflammatory drug with antipyretic, analgesic, and potential antineoplastic properties.


vintafolide

From vin- (“vinca alkaloid”) + [Term?] + folyl + -ide.

(pharmacology) A drug, being investigated as a cancer treatment, that combines vinblastine with a small molecule targeting the folate receptor.


ruxolitinib

For example, Gallipoli et al. reported that combination of nilotinib with ruxolitinib could induce apoptosis in chronic myeloid leukemia (CML) stem cells through inhibiting JAK-2/STAT-5 signaling pathway.

The first jakinib to enter clinical trials, initially for renal transplantation, was tofacitinib, which inhibits JAK1/JAK2/JAK3; however, ruxolitinib, a JAK1/JAK2 inhibitor, was the first agent to receive approval, as a treatment for myeloproliferative neoplasms that often exhibit gain-of-function JAK2 mutations.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2168:

(pharmacology) A medication belonging to the class of Janus kinase inhibitors, used for the treatment of several diseases including myelofibrosis and polycythemia vera.


mofetil

With respect to the cytotoxic effects, compounds 2–7 fall into two groups: the alkyl esters ( 2, 3 ) and the mofetil ester 4 on one hand, and the basic heterocyclic esters 5–7 on the other hand.

2015 July 22, “Esters of Bendamustine Are by Far More Potent Cytotoxic Agents than the Parent Compound against Human Sarcoma and Carcinoma Cells”, in PLOS ONE, →DOI:

(pharmacology) Contraction of morpholinoethyl.


antidysentery

(pharmacology) Working against dysentery.


quant suff

Borrowed from Latin quantum sufficit (“as much as is required”), then clipped to only the first syllable of each word.

bor

(pharmacology, dated) The amount of the last ingredient in a recipe or prescription required to make it up to the required quantity of a mixture.


daclatasvir

In contrast, the HIV-1 protease inhibitor nelfinavir or the HCV NS5A inhibitor daclatasvir only blocks the replication of a single virus in the “co-infection” system.

2015 August 12, “The Novel Cyclophilin Inhibitor CPI-431-32 Concurrently Blocks HCV and HIV-1 Infections via a Similar Mechanism of Action”, in PLOS ONE, →DOI:

(pharmacology) A drug for the treatment of hepatitis C.


elbasvir

(pharmacology) An experimental drug for the treatment of hepatitis C.


grazoprevir

A phase-II multicenter study has assessed the efficacy and safety of the combination of grazoprevir (MK-5172) and elbasvir (MK-8742) given to patients with chronic hepatitis and chronic kidney disease, including hemodialysis patients […]

2015 July 16, Mireille Mehawej et al., “Boceprevir-Based Triple Antiviral Therapy for Chronic Hepatitis C Virus Infection in Kidney-Transplant Candidates”, in Journal of Transplantation, volume 2015, →DOI:


aclidinium

From [Term?] + -clidinium (“muscarinic receptor agonist/antagonist”).

af

(pharmacology) A particular muscarinic antagonist, administered in the bromide form.


indacaterol

From ind(enyl) + ca(rbostyril) + -terol (“phenethylamine derivative”).

chronic obstructive pulmonary disease
chronic obstructive pulmonary disease

(pharmacology) An ultra-long-acting beta-adrenoceptor agonist used in the treatment of chronic obstructive pulmonary disease.


oclacitinib

Delgocitinib (JTE-052) is a topical jakinib approved in Japan for atopic dermatitis and oclacitinib, a JAK1/JAK2/JAK3 inhibitor, is approved for canine allergic dermatitis.

2021 December, Christine Liu, Jacqueline Kieltyka, Roy Fleischmann, Massimo Gadina, John J. O’Shea, “A Decade of JAK Inhibitors: What Have We Learned and What May Be the Future?”, in Arthritis & Rheumatology, volume 73, number 12, →DOI, page 2170:

(pharmacology) A veterinary medication belonging to the class of Janus kinase inhibitors, used for the treatment of atopic dermatitis in dogs.


chloral hydrate

/ˌklɔɹˌæl ˈhaɪˌdɹeɪt/

(organic chemistry, pharmacology) An organic compound with the chemical formula C₂H₃Cl₃O₂, used as a sedative and hypnotic drug and as a laboratory reagent and precursor.


pyrrolobenzodiazepine

From pyrrol + -o- + benzo- + di- + azepine.

SG2000 (SJG-136, NSC694501) is a rationally designed pyrrolobenzodiazepine dimer which interacts sequence selectively in the minor groove of DNA.

2015 August 19, Maria Mellinas-Gomez et al., “Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours”, in BMC Veterinary Research, volume 11, →DOI:

(pharmacology) A class of compounds with antibiotic and anti-tumor properties.


hypertoxic

The hypertoxic case has, as a rule, a characteristically poor rash, and in estimates of the result of treatment too much attention need not be paid to what happens to the rash; a plentiful distribution of the toxin into the cutaneous tissues probably acts as a safety-valve.

In a paper read before the Academiè royale de Medècine de Belgique (Procès-verbal, April, 1892), Dr. Masius shows that in doses generally considered as hypertoxic, digitalis may be taken not only without inconvenience, but that such massive doses will surely and rapidly prevent the dangers arising from cardiac weakness and from a high temperature?

1829, Philadelphia College of Pharmacy and Science, American Journal of Pharmacy, Philadelphia, page 468:

We often find in insanity an inverse toxicity of the urine, and the blood, in mania especially, is as much more hypertoxic as the urine is hypotoxic.

1832, Royal Academy of Medicine in Ireland, Irish Journal of Medical Science, Dublin, page 153:


prontosil

In the field of therapeutic aids, chemotherapy and antibiotics have been completely developed since that time. We had prontosil and neoprontosil and thought we were very fortunate.

1951 July, Richard D. Reekie, “Critical Analysis of Recent Advances in Gynecology”, in Northwest Medicine, volume 50, number 7, Portland, Ore.: Northwest Medical Publishing Association, page 508:

Since 1935 when Domagk demonstrated that prontosil provided effective therapy in a murine pneumococcal infection model, the use of animal infection models has become an integral part of the evaluation of new antimicrobial agents and new therapeutic approaches for clinical trials in humans.

2015 July 25, Mengxiao Gu et al., “Response of a clinical Escherichia coli strain to repeated cefquinome exposure in a piglet tissue-cage model”, in BMC Veterinary Research, volume 11, →DOI:

(pharmacology) The antibacterial drug 4-[(2,4-diaminophenyl)azo]benzenesulfonamide.


counteradaptation

en-noun

counteradaptation (countable and uncountable, plural counteradaptations)

Repeated AOD exposure also can lead to adaptations in the reward circuitry that oppose and neutralize a drug's effects (i.e., counteradaptation).

1997, Alcohol Health and Research World- Volume 21:

Counteradaptation postulates that the initial positive rewarding feelings are followed by the opposing development of tolerance.

2010, Marie A. Chisholm-Burns, Terry L. Schwinghammer, Barbara G. Wells, Pharmacotherapy Principles and Practice, page 610:

The conceptual framework of opponent process counteradaptation involves an initial a-process (positive hedonic effect; "light side") occurring shortly after presentation of the reinforcer followed by a b-process (negative hedonic effect; "dark side") appearing after the a-process has terminated.

2011, William R. Miller, Kathleen M. Carroll, Rethinking Substance Abuse:

Sensitization and counteradaptation are two of the major neuroadaptive models that have been proposed to explain how changes that start in the reward pathway may result in the development of substance dependence.

2013, John E. Niederhuber, James O. Armitage, James H Doroshow, Abeloff's Clinical Oncology, page 363:

adaptation that counters a change to an organism's environment

(pharmacology) The development of tolerance; the adaptation of the body's homeostatic mechanisms to counteract a drug effect.


umeclidinium

(pharmacology) An anticholinergic drug used in the bromide form, in combination with vilanterol, for the treatment of chronic obstructive pulmonary disease.


vilanterol

From [Term?] + -terol (“phenethylamine derivative”).

af

(pharmacology) A long-acting beta-2 agonist drug, used in the treatment of chronic obstructive pulmonary disease.


-olol

From propranolol. By surface analysis, reduplication of -ol.

β-adrenoceptor
w:adrenergic receptors#β receptors

(pharmacology) Used to form names of compounds with the structure Ar–OCH₂CH(OH)CH₂NH–R used as β-adrenoceptor antagonists.


wine o'clock

(mm - how long till wine o'clock? Damn, I think it's still about 3 or 4 hours!)

2000 August 31, The Evil Queen [username], “Re: Where ya from?”, in soc.subculture.bondage-bdsm.femdom (Usenet):

Then I'd spend Saturday a bundle of hangover nerves, waiting for Saturday wine o'clock to make it disappear.

2014, Binki Laidler, Staying Sober: How to Control the Drink Demon, Accent Press, →ISBN:

Thank God it was wine o'clock.
I gulped, rather than sipped my glass of wine, then fell back in the armchair.

2014, Belinda Williams, The Boyfriend Sessions, Momentum, →ISBN:

(slang, humorous) The time of the first glass of wine (or alcoholic beverage) of the day.


darexaban

From [Term?] + -xaban (“blood coagulation factor Xa inhibitor”).

(pharmacology) An experimental drug that acts as an anticoagulant and antithrombotic.


betrixaban

The problem of renal excretion, and so, inadvisability in the face of low creatinine clearance, may be addressed by betrixaban, little of which is excreted via this organ.

2015 August 20, Andrew Blann, “Nonvitamin K antagonist oral anticoagulants (NOACs): the tide continues to come in”, in Vascular Health and Risk Management, volume 11, →DOI:

(pharmacology) A particular anticoagulant drug.


fostamatinib

From fos- (“phosphorous derivative”) + [Term?] + -tinib (“tyrosine kinase inhibitor”).

(pharmacology) A particular drug that is an inhibitor of the enzyme spleen tyrosine kinase (Syk).


dasabuvir

From [Term?] + -buvir (“RNA polymerase (NS5B) inhibitor”).

(pharmacology) An antiviral drug for the treatment of hepatitis C virus infection.


miravirsen

From [Term?] + -virsen (“antiviral antisense oligonucleotide”).

Currently, miravirsen is applied in seven clinical trials, some are already in phase II.

2015 August 13, Merav Kedmi et al., “MicroRNAs and Growth Factors: An Alliance Propelling Tumor Progression”, in Journal of Clinical Medicine, volume 4, →DOI:

(pharmacology) A locked nucleic acid-based antisense oligonucleotide with potential medical applications.


fumarium

/fjuːˈmɛəɹɪəm/

(history) A smoke chamber used in Ancient Rome to enhance the flavor of wine.

fūmārium

Ancient Roman smoke chamber used for maturing wine


ertugliflozin

From [Term?] + -gliflozin (“phlorizin derivative”).

(pharmacology) A particular gliflozin drug.


gliflozin

(pharmacology) Any of a class of drugs that inhibit renal glucose reabsorption and therefore lower blood glucose.


imepitoin

From im(idazolone) + [Term?] + -toin (“hydantoin derivative”).

(pharmacology) A particular antiepileptic drug.


fenpiverinium

From (di)phen(yl) + pi(peridine) + -verine (“spasmolytic”) + -ium (“quaternary ammonium compound”).

(pharmacology) A particular antimuscarinic drug.


remogliflozin

remogliflozin etabonate
remogliflozin etabonate#English

(pharmacology) Synonym of remogliflozin etabonate.


empagliflozin

From empa- (of unknown origin) + -gliflozin (“sodium–glucose cotransporter inhibitor”).

(pharmacology) An orally available competitive inhibitor of sodium–glucose co-transporter 2 (SGLT2; SLC5A2) with antihyperglycemic activity.


migalastat

From [Term?] + -stat (“enzyme inhibitor”).

Based on preclinical data, migalastat HCl in combination with agalsidase is expected to result in the pharmacokinetic (PK) enhancement of agalsidase in plasma by increasing the systemic exposure of active agalsidase, thereby leading to increased cellular levels in disease-relevant tissues.

2015 August 8, “Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase”, in PLOS ONE, →DOI:

(pharmacology) A drug used to treat Fabry disease


faldaprevir

From [Term?] + -previr (“hepatitis C virus protease inhibitor”).

In similar pharmacokinetic studies in healthy volunteers, faldaprevir concentrations were increased by ritonavir-boosted darunavir, and decreased by tenofovir and efavirenz, which may ultimately require dose adjustments of the HCV PI in the presence of certain ARVs.

2013 December 15, Tilahun Amdissa Gemtessa, Lisa M. Chirch, “Update on Hepatitis C Virus and HIV Coinfection”, in Journal of Clinical and Translational Hepatology, volume 1, →DOI:

(pharmacology) An experimental drug for the treatment of hepatitis C.


ospemifene

From [Term?] + [Term?] + -mifene (“clomifene derivative”).

While raloxifene and tamoxifen have no estrogen agonist effect on the vagina, lasofoxifene and ospemifene show a positive impact on vaginal tissue in postmenopausal women.

2015 August 28, Hyun-Kyung Kim et al., “The Recent Review of the Genitourinary Syndrome of Menopause”, in Journal of Menopausal Medicine, volume 21, →DOI:

(pharmacology) An oral medication used to treat dyspareunia.


ripasudil

Some selective ROCK inhibitors are actually used in clinical practice, for example, fasudil and ripasudil are therapeutic agents for cerebral vasospasm and glaucoma, respectively.

2015 September 15, “Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study”, in PLOS ONE, →DOI:

(pharmacology) A drug derived from fasudil and used to treat glaucoma and ocular hypertension.


sitamaquine

Apart from amphotericin B and sitamaquine that can be considered as control drugs in this screening, clofazimine was the only compound exhibiting activity in the Leishmania donovani intracellular assay as well as an acceptable level of selectivity (SI ~10) (Table 3, S4 Fig ).

2015 August 14, “Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning”, in PLOS ONE, →DOI:

(pharmacology) A particular aminoquinoline that may be a antileishmanial drug


pictilisib

Trametinib and pictilisib (GDC-0941) were obtained from Selleck Chemical.

2015 September 25, “Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas”, in PLOS ONE, →DOI:


mogamulizumab

From [Term?] + -li- (“immunomodulating”) + -zumab (“humanized monoclonal antibody”).

(pharmacology) A humanized monoclonal antibody used to treat adult T-cell leukemia/lymphoma.


onartuzumab

From [Term?] + -tu- (“tumor”) + -zumab (“humanized monoclonal antibody”).

This publication describes the safety profile of onartuzumab in patients with solid tumors using data from the global onartuzumab clinical development program.

2015 October 8, “Safety of Onartuzumab in Patients with Solid Tumors: Experience to Date from the Onartuzumab Clinical Trial Program”, in PLOS ONE, →DOI:

(pharmacology) A humanized monoclonal antibody designed to treat cancer.


iodopovidone

After cleaning the surgical areas with iodopovidone, the swine were then instrumented with a right internal jugular pulmonary artery catheter through an 8 French introducer, a right femoral vein 10 French introducer and a right femoral artery triple lumen catheter.

2015 September 15, “Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation”, in PLOS ONE, →DOI:

(pharmacology) Synonym of povidone-iodine


ferroquine

(pharmacology) A particular antimalarial drug.


-onium

Alternative form: -ium

quaternary ammonium compound
quaternary ammonium compound#English

neuromuscular blocking agent
w:neuromuscular-blocking drug

(pharmacology) Used to form names of quaternary ammonium compounds used as neuromuscular blocking agents, cholinergic agents, anticholinergic agents, antibacterials/antiseptics, or other agents.


phagostimulant

The infectious meal was prepared with fresh washed bovine red cells, viral supernatant (1:2) and adenosine triphosphate at 5 mM as phagostimulant.

2015 September 16, “Use of Centrifugal Filter Devices to Concentrate Dengue Virus in Mosquito per os Infection Experiments”, in PLOS ONE, →DOI:

(pharmacology) Any material that stimulates the production of phagocytes


dolutegravir

From [Term?] + -tegravir (“HIV integrase inhibitor”).

Indeed, French regulations’ approval for the dolutegravir and the elvitegravir are posterior to the end of the data collection for this study.

2015 October 21, “Antiretroviral Regimens and CD4/CD8 Ratio Normalization in HIV-Infected Patients during the Initial Year of Treatment: A Cohort Study”, in PLOS ONE, →DOI:

(pharmacology) An integrase inhibitor used to treat HIV infections.


rucaparib

Niraparib was selected because it was the only PARPi in clinical trials with temozolomide at the time of this study, and rucaparib and BMN-673 were selected because they are potent PARP trappers.

2015 October 28, “Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma”, in PLOS ONE, →DOI:

A drug being developed as a cancer treatment.


cephalopolysyndactyly

From cephalo- + polysyndactyly or cephalo- + poly- + syn- + dactyl + -y.

Greig cephalopolysyndactyly syndrome

(pathology, teratology) A disorder that affects development of the limbs, head, and face.


alexipharmac

Borrowed from Middle French alexipharmaque (modern French alexipharmaque (archaic)), and from its etymon Latin alexipharmacon (“antidote”) (whence Late Latin alexipharmacum), from Ancient Greek ἀλεξῐφᾰ́ρμᾰκον (alexiphármakon, “antidote; (generally) remedy; charm, spell”), a noun use of the neuter of ἀλεξῐφᾰ́ρμᾰκος (alexiphármakos, “acting as an antidote”), from ἀλέξειν (aléxein) (the active infinitive of ἀλέξω (aléxō, “to defend, guard, protect; to help; to keep off, turn aside, ward off”), ultimately from Proto-Indo-European *h₂lek- (“to protect”)) + φάρμᾰκον (phármakon, “drug, whether healing or poisonous; charm, potion, spell; colour, dye”) + -ος (-os, suffix forming certain types of adjectives).

der

ἀλεξῐφᾰ́ρμᾰκον

/əˌlɛksɪˈfɑːmæk/

/əˌlɛksəˈfɑɹmæk/

(pharmacology, chiefly archaic or historical) A medical remedy for protecting the body, or an antidote, against a harmful substance, especially a poison or venom (specifically, that of a snake); an alexipharmic, an antidote.

alexipharmaque

medical remedy for protecting the body, or an antidote, against a harmful substance, especially a poison or venom — see also antidote


alexipharmac

en-adj

alexipharmac (comparative more alexipharmac, superlative most alexipharmac)

more alexipharmac (comparative)
most alexipharmac (superlative)

Borrowed from French alexipharmaque (archaic), and from its etymon Late Latin alexipharmacus, from Ancient Greek ἀλεξιφάρμακος (alexiphármakos) (see etymology 1).

der

ἀλεξιφάρμακος

/əˌlɛksɪˈfɑːmæk/

/əˌlɛksəˈfɑɹmæk/

(pharmacology, chiefly archaic or historical) Of or pertaining to an alexipharmac; also, acting as an alexipharmac by protecting against or warding off the ill effects of a harmful substance, especially a poison or venom; alexipharmic.

alexipharmaque

of or pertaining to an alexipharmac; acting as an alexipharmac


okolehao

A distilled beverage made from the ti root, and often containing other ingredients, such as sugar cane and pineapple.


rifaximin

(pharmacology) A semisynthetic antibiotic based on rifamycin.


new wine

en-noun

new wine (countable and uncountable, plural new wines)

From Middle English newe wijne, from Old English nīwe wīn, equivalent to new + wine. Name taken from several places in the Holy Bible, most notably Acts 2:13 and Luke 5:37.

Wine that has fermented for a short amount of time.

Any number of Christian revivals and New Christian movements.


besifloxacin

From [Term?] + -floxacin (“nalidixic acid derivative”).

af

(pharmacology) A particular fluoroquinolone antibiotic.


fostemsavir

From fos- (“phosphorous derivative”) + temsavir.

(pharmacology) An experimental HIV entry inhibitor that is a prodrug of temsavir.


pradofloxacin

(pharmacology) A particular veterinary antibiotic of the fluoroquinolone class.


viniculturist

A person who practices viniculture; a viticulturist specifically involved in wine production.


briakinumab

From -kin- (“interleukin”) + -umab (“human monoclonal antibody”).

As another interleukin 12/23 antagonist, briakinumab, was withdrawn from further development in part due to concerns about cardiovascular safety, discussion has also emerged on cardiovascular safety of ustekinumab.

2015 December 4, “Patient Preferences for Biologicals in Psoriasis: Top Priority of Safety for Cardiovascular Patients”, in PLOS ONE, →DOI:

rheumatoid arthritis
rheumatoid arthritis

(pharmacology) A human monoclonal antibody being developed to treat rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.


bum wine

en-noun

bum wine (countable and uncountable, plural bum wines)

(colloquial, derogatory) Cheap wine of very low quality, sold solely for the purposes of intoxication.


deleobuvir

From [Term?] + -buvir (“RNA polymerase (NS5B) inhibitor”).

af

(pharmacology) An experimental drug for the treatment of hepatitis C.


brodalumab

From -l- (“immunomodulating”) + -umab (“human monoclonal antibody”).

(pharmacology) A human monoclonal antibody designed to treat inflammatory diseases such as psoriasis.


ixekizumab

From [Term?] + -ki- (“interleukin”) + -zumab (“humanized monoclonal antibody”).

More recently, other biological drugs, such as ustekinumab, ixekizumab, tofacitinib, secukinumab and briakinumab, have targeted immunological mediators of the disease.

2015 December 12, “Evolution of Cooperation Patterns in Psoriasis Research: Co-Authorship Network Analysis of Papers in Medline (1942–2013)”, in PLOS ONE, →DOI:

(pharmacology) A humanized monoclonal antibody for the treatment of autoimmune diseases. It works by binding to interleukin 17 and blocking its action.


luseogliflozin

From [Term?] + -gliflozin (“phlorizin derivative”).

To evaluate the cardiac safety of luseogliflozin, a thorough QT/QTc study was conducted in healthy Japanese subjects.

2015 October 8, “Randomized, Controlled, Thorough QT/QTc Study Shows Absence of QT Prolongation with Luseogliflozin in Healthy Japanese Subjects”, in PLOS ONE, →DOI:

(pharmacology) The thioglycoside 1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol that is used to treat diabetes


maderization

Maderization turns wine brownish and gives it a flat, dull taste. Unprotected by tannins and pigments, white wines are more susceptible to maderization than red wines.

1988, Ted Meredith, Northwest wine companion, page 111:


pentaquine

(pharmacology) Alternative form of pentaquin


pharmacian

From pharmacy + -ian, probably after the model of French pharmacien.

The analogy of these bases to metallic oxides and their valuable applications in medicine have rendered the class a favourite study with both chemists and pharmacians.

1843, Thomas Graham, Robert Bridges, Elements of Chemistry, page 657:

(rare, archaic) Synonym of pharmacist: a person who sells medicines.


pharmacopole

From Latin pharmacopola, from Ancient Greek φαρμακοπώλης (pharmakopṓlēs), from φάρμακον (phármakon, “drug, charm, enchantment”) + -πώλης (-pṓlēs, “-seller, -monger”). Doublet of pharmacopolist.

der

φαρμακοπώλης

(archaic) Synonym of quack: a peddler of fraudulent medicines and cures.


macitentan

From [Term?] + -entan (“endothelin receptor antagonist”).

af

Right and left ventricular collagen content was increased with pulmonary artery banding compared to sham-operated controls and ameliorated by macitentan.

2016 January 15, “Dual Endothelin Receptor Blockade Abrogates Right Ventricular Remodeling and Biventricular Fibrosis in Isolated Elevated Right Ventricular Afterload”, in PLOS ONE, →DOI:

(pharmacology) An endothelin receptor antagonist used to treat pulmonary arterial hypertension.


methhead

(derogatory slang) A person who is addicted to or routinely uses methamphetamines.


torito

A combination of sweetened condensed and evaporated milks with cane liquor and peanuts or local fruits, the cocktail reenergized the laborers, who began calling it torito — or “little bull” — because they felt it gave them the strength of a bull.

2024 January 20, Massarah Mikati, “Torito, a creamy Mexican cocktail, hasn’t hit mainstream America—yet. This mother-daughter duo is bringing it to Philadelphia.”, in The Philadelphia Inquirer:

A sweet creamy cocktail originating in Mexico.


saroglitazar

/ˌsæɹ.əˈɡlɪt.əˌzɑɹ/

Probably from s(ulfanyl) + ar(yl) + -o- + -glitazar (“peroxisome proliferator activated receptors-α and -γ agonist”).

(pharmacology) A particular glitazar for the treatment of type 2 diabetes mellitus and dyslipidemia.


doxercalciferol

(pharmacology) A synthetic analogue of ergocalciferol, used as a drug to treat secondary hyperparathyroidism and metabolic bone disease.


selisistat

From [Term?] + -stat (“enzyme inhibitor”).

In contrast, a SIRT1 inhibitor, selisistat, has been reported to alleviate HD-related phenotypes in multiple HD models and has been found to be safe in clinical trials.

2016 January 28, “SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington’s Disease Mice”, in PLOS ONE, →DOI:

(pharmacology) A particular SIRT1 inhibitor drug.


trap house

From trap (“vehicle or location used for drug exchange or manufacture”) + house.

compound

2015, Anthony Abraham Jack, "Crisscrossing Boundaries: Variation in Experiences with Class Marginality Among Lower-Income, Black Undergraduates at an Elite College", in Elizabeth M. Lee & Chaise LaDousa (eds.), College Students’ Experiences of Power and Marginality: Sharing Spaces and Negotiating Differences, Routledge, →ISBN reporting a respondent's statement.
We have a couple of trap houses on our block. Trap houses like drug houses, drug dealers.

(African-American Vernacular) A place where illegal drugs are manufactured, packaged for sale, or sold on the street.


triciribine

From tricy(clic) + -ribine (“ribofuranosyl derivative of the pirazofurin type”).

af

(pharmacology) A cell-permeable tricyclic nucleoside used to treat cancer.


cabotegravir

From [Term?] + -tegravir (“HIV integrase inhibitor”).

(pharmacology) An integrase inhibitor used to treat HIV infection.


brallobarbital

(pharmacology) A barbiturate drug, now disused because of its disagreeable side effects.


rupintrivir

From [Term?] + [Term?] + -vir (“antiviral”).

(pharmacology) A particular synthetic protease inhibitor used as an antiviral drug.


nonstimulant

A starch blocker is a nonstimulant, 100 per cent natural nutritional supplement derived from the white kidney bean.

2009 May 14, Malena Harbers, Toronto Star:

(pharmacology) Any substance that is not a stimulant.


angel dusting

(advertising, marketing, pharmacology) The misleading marketing practice of including a minuscule amount of an active ingredient in a product (such as food or cosmetics), insufficient to give any measurable benefit.


Vouvray

A white wine from the commune of Vouvray in central France.


back-sweeten

en-verb

back-sweeten (third-person singular simple present back-sweetens, present participle back-sweetening, simple past and past participle back-sweetened)

back-sweetens (present singular third-person)
back-sweetening (participle present)
back-sweetened (participle past)
back-sweetened (past)

(transitive, brewing) To sweeten (an alcoholic drink) after fermentation by adding further sugar.


polypin

(UK, brewing) A plastic version of the kind of brewery cask called a pin (equal to half a firkin), popular in homebrewing and the off-trade (deliveries for home consumption).


maribavir

From [Term?] + rib(osyl) + -a- + -vir (“antiviral”).

af

(pharmacology) An experimental antiviral drug for the prevention and treatment of human cytomegalovirus disease in transplant patients.


vismodegib

Among the inhibitors of the Hh pathway that interact directly with SMO, vismodegib and sonidegib are the two compounds approved by FDA in 2012 and 2015, respectively, for the treatment of basal cell carcinoma (BCC).

2016 March 3, “Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells”, in PLOS ONE, →DOI:

basal cell carcinoma
basal cell carcinoma

(pharmacology) A drug targeting the smoothened protein of the hedgehog signaling pathway, used for the treatment of basal cell carcinoma.


vino collapso

An Italian-sounding parody name, from Italian vino + collapse + -o.


dago red

en-noun

dago red (countable and uncountable, plural dago reds)

(slang, offensive) Cheap, inferior red wine.


Corona

All ultimately from Latin corōna (“crown”).
* (Corona, California): From Spanish corona (“crown, wreath”), chosen to play upon a unique feature of the city, the one-mile diameter drive that circled the center of the town.
* (Corona, New Mexico):
* (Corona, South Dakota): May be a transfer from Corona, Queens.
* (Corona, Queens): One theory is that it was renamed by music producer Benjamin W. Hitchcock, a developer who renamed the area in 1872 and sold off land for residential development. Another theory is that real estate developer Thomas Waite Howard, who became the first postmaster in 1872, petitioned to have the post office name changed to Corona in 1870, suggesting that it was the “crown of Queens County”. A third theory is that it is derived from the crown used as an emblem by the Crown Building Company, which is said to have developed the area. The Italian immigrants who moved into the new housing stock referred to the neighborhood by Italian corona or Spanish corona (“crown”).
* (surname): 1. From Spanish corona and Italian corona (“crown”), perhaps applied as a habitational name for someone who lived in a house with this sign, or as a nickname for someone who had a tonsure in fulfillment of a religious vow or who had influence and power. 2. From Italian Corona, a female given name, of the same derivation.
* (given name): From Late Latin Corōna, meaning “crown”.
* (beer): From Spanish corona (“crown”).
* (coronavirus): Clipping of coronavirus, from corona + virus.
* (cigar): From Spanish La Corona (literally “The Crown”), the name of a brand.

bor

LuLaRoe is laying off 167 employees at a warehouse in Corona, California, on December 20, according to a company filing. […] LuLaRoe confirmed the closing to Business Insider and said it will maintain separate offices in Corona that serve as its headquarters.

2019 October 28, Hayley Peterson, “LuLaRoe plans to lay off 167 warehouse workers amid legal battle”, in Business Insider:

Riverside County
Riverside County#English

A place in the United States:
A city in Riverside County, California.

An unincorporated community in Carlton County, Minnesota.

An unincorporated community in Oregon County, Missouri.


dermatotoxic

en-adj

dermatotoxic (comparative more dermatotoxic, superlative most dermatotoxic)

more dermatotoxic (comparative)
most dermatotoxic (superlative)


-sal

(pharmacology) Used to form names of salicylic acid derivatives.


orestrate

From [Term?] + -estr- (“estrogen”) + -ate.

(pharmacology) A synthetic steroidal estrogen, the 3-propanoyl, 17-(1-cyclohexenyl) ether of estradiol.


fosfestrol

From phosph(ate) + -estr- (“estrogen”) + -ol.

(pharmacology) Diethylstilbestrol diphosphate, a synthetic non-steroidal estrogen of the stilbestrol group, used in the treatment of prostate cancer.


nilestriol

(pharmacology) A synthetic steroidal estrogen, the 3-cyclopentyl ether of 17α-ethinyl estriol.


cloxestradiol

From (tri)chlo(ro) + (hydr)ox(y) + estradiol.

(pharmacology) A synthetic steroidal estrogen, an analogue of estradiol with a 2,2,2-trichloroethoxy substitution.


estrapronicate

From estra(diol) + pro(pionate) + -nicate (“antihypercholesterolemic or vasodilating nicotinic acid ester”).

af

(pharmacology) Estradiol 17-nicotinate 3-propionate, a synthetic steroidal estrogen.


droloxifene

From (hy)dro(xy)l + -oxifene (“tamoxifen derivative”).

(pharmacology) A particular antiestrogen.


arzoxifene

From [Term?] + [Term?] + -oxifene (“tamoxifen derivative”).

(pharmacology) A particular selective estrogen receptor modulator.


finerenone

From [Term?] + -renone (“spironolactone derivative”).

If the FDA expands the use of finerenone as a heart failure therapy, cardiologist Dr. Michelle Bloom said, she would think about it as an option for her patients with mildly reduced or preserved ejection fraction.

2024 January 9, Jacqueline Howard, “Kidney disease medication found to reduce risk of cardiovascular death in certain heart failure patients in new study”, in CNN:

(pharmacology) A non-steroidal antimineralocorticoid in trials for the treatment of chronic heart failure.


methestrol

(pharmacology) A synthetic non-steroidal estrogen of the stilbestrol group.


hexestrol

(pharmacology) A synthetic non-steroidal estrogen of the stilbestrol group, formerly used to treat estrogen deficiency.


fenestrel

(pharmacology) A synthetic, non-steroidal estrogen developed as a postcoital contraceptive in the 1960s but was marketed.


melomel

en-noun

melomel (countable and uncountable, plural melomels)

In Digbie's era metah, metheglin, and melomel were probably considered synonyms. […] "Melomel" today usually means a mead flavored with any fruit juice other than apples or pears. Peaches, cherries, blackberries, or plumbs^([sic]) are some good, historic choices.

2001, David Alan Woolsey, Libations of the Eighteenth Century: A Concise Manual for the Brewing of Authentic Beverages from the Colonial Era of America, and of Times Past:


bochet

bochet (usually uncountable, plural bochets)

A form of mead made from honey that has been caramelized.


medovukha

Borrowed from Russian медовуха (medovuxa).

An Eastern Slavic drink resembling mead.


morat

An ancient drink resembling mead, made with mulberries.


escaline

3,5-methoxy-4-ethoxyphenethylamine, a psychedelic drug and entheogen of the phenethylamine class.


rolicyclidine

From (pyr)roli(dine) + cycl(ohexyl) + -clidine (“muscarinic receptor agonist/antagonist”).

af

(pharmacology) A dissociative anesthetic drug with hallucinogenic and sedative effects.


Singapore sling

en-noun

Singapore sling (plural Singapore slings)

From Singapore, as the drink was developed at Singapore's Raffles Hotel + sling.

Our glasses, used for Singapore slings, were tall and full.

1969, Allen V. Ross, Vice in Bombay, London: Tallis Press, page 138:


machine elf

Coined by American ethnobotanist and author Terence McKenna (1946–2000), who advocated the responsible use of naturally occurring psychoactive plants.

[…] I describe them as self-transforming machine elves, for that is how they appear. These entities are dynamically contorting topological modules that are somehow distinct from the surrounding background, which is itself undergoing continuous transformation. […] The tryptamine Munchkins come, these hyperdimensional machine-elf entities, and they bathe one in love. It's not erotic but it is openhearted. It certainly feels good. These beings are like fractal reflections of some previously hidden and suddenly autonomous part of one's own psyche. And they are speaking, saying, "Don't be alarmed. Remember, and do what we are doing."

1983 December, Terence McKenna, “Tryptamine Hallucinogens and Consciousness”, in The Archaic Revival: Speculations on Psychedelic Mushrooms, the Amazon, Virtual Reality, UFOs, Evolution, Shamanism, the Rebirth of the Goddess, and the End of History, [San Francisco, Calif.]: HarperSanFrancisco, published 1991, →ISBN:

I found myself in the sort of auric equivalent of the Pope's private chapel, and there were insect elf machines proffering strange little tablets with strange writing on them. And it all went on, they were speaking in some kind of—there were these self-transforming machine-elf creatures—were speaking in some kind of colored language which condensed into rotating machines that were like Fabergé eggs, but crafted out of luminescent super-conducting ceramics, and liquid crystal gels, and all this stuff was so weird, and so alien, and so "un-English-able" that it was a complete shock.

1988, Diana Reed Slattery, quoting Terence McKenna, Xenolinguistics: Psychedelics, Language, and the Evolution of Consciousness, Berkeley, Calif.: Evolver Editions, North Atlantic Books, published 2015, →ISBN:

Nearly everyone who smokes DMT reports hearing a high-pitched tone corresponding to what they believe is a ‘carrier wave’ of reality at that moment. The visual world begins to vibrate at the same frequency until everything breaks up into geometric patterns and crystalline twinkles. This is when the ‘machine elves’ show up, if they’re going to.

1994, Douglas Rushkoff, Cyberia: Life in the Trenches of Hyperspace, →ISBN, page 121:

There were times when I would watch this action for 45 minutes at a time … so long that the gravity of watching these melting Lego-beings (machine elves?) slice little pieces of themselves off, to create emotions and other information, was lost in boredom. (This has to be the machine elves. McKenna may have missed something by not investigating DXM—namely that the machine elf world appears to be self/brain.)

2004 December 1, Dan Carpenter, “The Invisible Landscape”, in A Psychonaut's Guide to the Invisible Landscape: The Topography of the Psychedelic Experience, Rochester, Vt.: Park Street Press, Inner Traditions – Bear & Company, published 2006, →ISBN, page 91:

A kind of otherworldly humanoid figure sometimes seen during dimethyltryptamine (DMT) hallucinations.


cinalukast

From [Term?] + -lukast (“leukotriene receptor antagonist”).

af

Using low scores for both R-enantiomer queries, the LBVS counter-screen ruled out exatecan acid, S-flunoxaprofen, gemfibrozil, cinalukast, fexofenadine, and tanomastat.

2015 November 12, “Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases”, in PLOS ONE, →DOI:

(pharmacology) The compound (E)-4-[[3-(2-(4-cyclobutyl-2-thiazolyl)ethenyl)phenyl]amino]-2,2-diethyl-4-oxobutanoic acid that is used in the treatment of asthma


pink panty dropper

en-noun

pink panty dropper (plural pink panty droppers)

LL-Q1860 (eng)-Flame, not lame-pink panty dropper.wav

So called from the colour and the idea that it lowers women's sexual inhibitions.

Gotta go, my love. Todd's buying pink panty droppers. Oh my, oh me, I'm trashed.

2013, Greg Kleiner, Georgie Mills, Strings, page 48:

It happened that Tameka brought more vodka with her and had planned to make them something called Pink Panty Droppers. That was until she saw them drinking Bloody Marys and wanted to try one.

A cocktail of usually beer and vodka with pink lemonade.


purple nasty

purple nasty (countable and uncountable, plural purple nasties)

LL-Q1860 (eng)-Flame, not lame-purple nasty.wav

From the drink's typical color, cloyingly sweet taste, and propensity to induce vomiting.

snakebite and black
snakebite and black#English

(UK, slang) Synonym of snakebite and black.


Blue Hawaii

LL-Q1860 (eng)-Flame, not lame-Blue Hawaii.wav

A cocktail of rum, pineapple juice, curaçao, sweet-and-sour mix, and sometimes vodka.


snakey B

snakey B (countable and uncountable, plural snakey Bs)


patritumab

From -tu- (“tumor”) + -umab (“human monoclonal antibody”).

af

For example, it has been demonstrated that cells overexpressing heregulin are sensitive to a combination of cetuximab and patritumab, an antibody against HER3, even though each antibody on its own is ineffective [18 ].

2015 November 17, “Combined Analysis of Plasma Amphiregulin and Heregulin Predicts Response to Cetuximab in Metastatic Colorectal Cancer”, in PLOS ONE, →DOI:

(pharmacology) A human monoclonal antibody designed for the treatment of cancer


party pill

(colloquial) Any of various recreational drugs, especially those whose main ingredient is benzylpiperazine.


pritelivir

From [Term?] + [Term?] + -vir (“antiviral”).

(pharmacology) A particular antiherpetic drug.


Aglianico

An Italian wine made with a black grape variety from Basilicata and Campania.


laninamivir

From [Term?] + -amivir (“neuraminidase inhibitor”).

(pharmacology) A neuraminidase inhibitor used to treat influenza.


the dose makes the poison

(toxicology) The damage that a substance causes is determined more by its quantity than by its essence.


Dog

The figurative sense "Newcastle Brown Ale" comes from the euphemism "I'm going to walk the dog" or "I'm going to see a man about a dog", meaning "I'm going to the pub for a drink". This was further popularised by a 1980s advertising campaign.

(astronomy, with definite article) The Dog Star; Sirius.


margatini

A martini cocktail made and served like a margarita, with tequila as an ingredient.


olomoucine

From Olomouc + -ine. Named after the city where it was discovered.

An inhibitor of cyclin-dependent kinase, derived from purine, used in oncology


seven and seven

en-noun

seven and seven (plural seven and sevens)

LL-Q1860 (eng)-Flame, not lame-seven and seven.wav

A highball made with Seagram's Seven Crown whiskey and 7 Up.


proarrhythmogenic

MicroRNAs are important mediators of proarrhythmogenic remodeling and have potential value as biomarkers in cardiovascular diseases.

2016 February 10, “MicroRNAs as Biomarkers for Acute Atrial Remodeling in Marathon Runners (The miRathon Study – A Sub-Study of the Munich Marathon Study)”, in PLOS ONE, →DOI:

(pharmacology) that promotes arrhythmogenesis


drug trafficking

The process of smuggling, distributing and selling illegal drugs.

narcotràfic

smuggling, distribution and sale of drugs


White Lady

Alternative letter-case form of white lady (“cocktail”).


Brandy Alexander

Brandy Alexander (plural Brandy Alexanders)

From brandy + alexander (an earlier cocktail made with gin). There are various theories involving people named Alexander, but no widely accepted individual.

compound

A cocktail made with brandy, cream and crème de cacao.


zoopharmacognosy

(zoology, pharmacology, medicine) The non-human knowledge and practise of medicine and medicaments (non-human animals' own knowledge, behaviours and culture, involving their own treatments of their own ailments).


pyramidon

From German Pyramidon, corresponding to pyr(azolone) + amid(e) + -on.

(pharmacology) A yellowish-white powder used as an antipyretic.


jet fuel

en-noun

jet fuel (countable and uncountable, plural jet fuels)

Near-synonym: (often synonymous) lamp oil

(aviation) The fuel that powers a jet aircraft.

(sometimes humorous, hyperbolic) Kerosene.

The fuel that powers a jet aircraft.
Kerosene.


sciacarello

A red wine grape variety grown in Corsica


burukutu

Sorghum bicolor
Sorghum bicolor#Translingual

Cenchrus americanus
Cenchrus americanus#Translingual

Pennisetum glaucum
Pennisetum glaucum#Translingual

An African alcoholic beverage, brewed from the grains of Guinea corn (Sorghum bicolor) and pearl millet (Cenchrus americanus, syn. Pennisetum glaucum)


benralizumab

From [Term?] + [Term?] + -li- (“immunomodulating”) + -zumab (“humanized monoclonal antibody”).

af

(pharmacology) A monoclonal antibody being developed for the treatment of asthma.


fletikumab

From -k- (“interleukin”) + -umab (“human monoclonal antibody”).

(pharmacology) A monoclonal antibody designed for the treatment of rheumatoid arthritis.


perakizumab

From [Term?] + -ki- (“interleukin”) + -zumab (“humanized monoclonal antibody”).

(pharmacology) A humanized monoclonal antibody designed for the treatment of arthritis.


dinutuximab

(pharmacology) A particular monoclonal antibody


mesilate

When nafamostat mesilate (SK Chemicals Life Science Biz., Seoul, Korea licensed by Torii Pharmaceutical Co., LTD, Tokyo, Japan) was used for anticoagulation during the ECMO, the maintenance dose was held at 0.4–1.5 mg/kg/h to maintain a partial thromboplastin time of 60–80 s [ 12 ].

2015 August 17, Kun Il Kim et al., “The pre-ECMO simplified acute physiology score II as a predictor for mortality in patients with initiation ECMO support at the emergency department for acute circulatory and/or respiratory failure: a retrospective study”, in Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, volume 23, →DOI:

(pharmacology) A salt or ester of an acid CH₄O₃S used especially in pharmaceutical preparations.


SARM

selective androgen receptor modulator
w:selective androgen receptor modulator

(pharmacology) Acronym of selective androgen receptor modulator.


singani

A South American pomace brandy distilled from white Muscat of Alexandria grapes in the high valleys of Bolivia.


snake wine

en-noun

snake wine (usually uncountable, plural snake wines)

An Asian alcoholic beverage produced by infusing whole snakes in rice wine or grain alcohol, and traditionally believed to have curative effects.


red devil

Police said they acted on a tip, arrested the brothers at home and confiscated some “red devil” (barbiturate) capsules.

1964 June 16, “Charges Changed in Brothers’ Cases”, in The Indianapolis Star, volume 62, number 11, Indianapolis, Ind., page 3:

He snapped his fingers and said, “Jack, you're lucky. I just remembered, my sick old man is got some red devils from a script at his pad. But the pad is way out on Hundred-and-six Street and Massie Avenue.[”]

1967, Iceberg Slim [Robert Beck], Trick Baby: The Story of a White Negro, New York, NY: Cash Money Content, →ISBN:

(slang) A capsule of secobarbital sodium, especially when used as a recreational drug.


parapharmaceutical

(pharmacology) alternative to pharmaceutical


parapharmaceutical

alternative medicine
alternative medicine


DMARD

(pharmacology) Initialism of disease-modifying antirheumatic drug.


simtuzumab

From [Term?] + -tu- (“tumor”) + -zumab (“humanized monoclonal antibody”).

af

(pharmacology) A humanized monoclonal antibody designed for the treatment of fibrosis by binding to LOXL2 and acting as an immunomodulator.


tendamistat

From [Term?] + -stat (“enzyme inhibitor”).

(pharmacology) A protein that is a microbial inhibitor of α-amylase


burundanga

“Are we bringing burundanga [a date rape drug]^([sic])? I got reinoles [another date rape drug]^([sic]) at a really good price. For the rapes,” a message read. “This trip is a baptism of fire to become a wolf,” read another.

2019 April 23, Meaghan Beatley, “The shocking rape trial that galvanised Spain’s feminists – and the far right”, in The Guardian, →ISSN:

Any of various hyoscine-based drugs, especially scopolamine, which have medical applications, are of limited (possibly illicit) recreational use and are used for criminal activities like rape or robbery because they can render the victim unconscious and are popularly thought to cancel their willpower.


country wine

French wine, made in a named region to a standard greater than ordinary table wine


Virgin Caesar

Blend of virgin + Bloody Caesar from non-alcoholic versions of drinks being labelled "virgin"

A non-alcoholic version of a Bloody Caesar composed of spices and a clamato juice base


Verde Mary

Blend of verde (“green”) + Bloody Mary From being a green cocktail like a bloody mary, and tomatillos being Latin American thus Spanish verde ("green" in Spanish)

An alcoholic cocktail using juiced and pulped green tomatillos in place of red tomatoes; with a mix of spices and a vodka base


shedista

If I have any complaint, it is that some of the pieces are too short. The interesting and informative article about the so-called shedistas — low-budget wineries that have sprouted up in and around Santa Barbara that are now turning out some of California’s most exciting wines — would have been even better with a few more pages.

2006 October 22, Michael Steinberger, “Drinking Deeply”, in The New York Times:

From South Africa’s stunningly beautiful winelands to “shedistas” making wine in California industrial parks, from ubiquitous California chardonnay to the obscure Sagrantino di Montefalco, he gives us straightforward but nicely written descriptions of how wine tastes and what it goes with.

2006 November 16, Fred Tasker, “Hedonism lite”, in The Miami Herald:

The typical Santa Barbara shedista narrative goes like this: you start working in the cellar of a bigger winery and learn the ropes: the region, the vinyards, and the growers. Eventually you borrow from relatives and max out your credit cards to rent a shed, buy a few tanks and a few tons of Syrah, design a label, and make your own wine. You share equipment and wine notes with friends. And you keep your day job in the meantime.

2012, Jay McInerney, A Hedonist in the Cellar: Adventures in Wine, →ISBN:


levomilnacipran

(pharmacology) A serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders.


sudoxicam

(pharmacology) A particular benzothiazine carboxamide that is a cyclooxygenase inhibitor


para-acetylaminophenol

By surface analysis, para- + acetyl + aminophenol.

surf

(pharmacology) A pharmaceutical drug used to treat pain and fever


N-acetyl-p-aminophenol

(pharmacology) Synonym of para-acetylaminophenol (acetaminophen / paracetamol / tylenol)


examorelin

From hexa- + -morelin (“growth hormone release–stimulating peptide”).

af

(pharmacology) A particular synthetic hexapeptide.


bismuth subsalicylate

(pharmacology) An antacid medication C₇H₅BiO₄ (trademark Pepto-Bismol) taken orally to relieve diarrhea, nausea, and indigestion.


avilamycin

(pharmacology) Any of a class of orthosomycin antibiotics produced by the fermentation of Streptomyces viridochromogenes.


CTZ

(pharmacology) Initialism of cyclothiazide.


evernimicin

From everni(nate) + -micin (“aminoglycoside, antibiotic”).

(pharmacology) An oligosaccharide antibiotic of the orthosomycin group.


sodabi

A liquor made from wine palm in Benin and Togo.


micromeritic

(pharmacology) Of or relating to small particles.


rum popo

Two glasses and a quart of Rum Popo quickly followed.

1990, Ray Auxillou, The Blue Hole, page 231:

[…] magazines, drinking rum popos, calling friends. Now, finally, she felt good. When she felt good she didn't need anyone and no one could touch her or hurt her or throw her away or tell her she wasn't good enough.

1991, Deborah Rebollar Pintonelli, Ego Monkey:

Hoping that he had missed Fido's passenger truck bringing the “Orangewalkqueños” to town to buy linoleum and rum popo, Don Poldo geared up to thirty-five MPH, just about as fast as he could push the old Morris.

2002, Gay Alden Wilentz, Memories, Dreams and Nightmares, page 46:

In that beautiful spirit we say: Merry Krismos — may every home in Belize have a ham and turkey, a batl pahn table, black cake and rum popo for the gentle folk, and a special gift for the little ones.

2018 December 22, “April 10 – better than bread and circus”, in Amandala: Belize's Leading Newspaper:

The flan ($8) was milky and smooth, and the optional rum popo — a rum crème that’s similar to egg nog — gave it a little kick.

2019 February 13, Lennie Omalza, “This Mexican restaurant might have the best guac around Louisville”, in Courier Journal:

If you happen to be visiting in December or January, you might be lucky enough to sample this unusual Christmas treat, which is traditionally served with a rum popo, a sort of Belizean eggnog.

2019 September 18, “10 unmissable Belizean food experiences”, in The Telegraph:

The first drink I ever learned how to make was a Rum Popo, made for my mother just as soon as she was comfortable letting me or my sister handle a knife.

2020, Ivy Mix, Spirits of Latin America, page 153:


gatter

But when I strove my flame to tell, / Says she, 'Come, stow that patter, / If you're a cove wot likes a gal, / Vy don't you stand some gatter?' / In course I instantly complied— / Two brimming quarts of porter, / With sev'ral goes of gin beside, / Drain'd Bet the Coaley's daughter.

Bet the Coaley's Daughter (traditional song)

(UK, slang, obsolete) Porter or other beer, or by extension any alcoholic drink.


NVP

(pharmacology) Abbreviation of nevirapine.


nanopharmaceutical

(chiefly in the plural, pharmacology) Any pharmaceutical produced using nanotechnology, or manufactured in the form of nanoparticles.


antipanic

It has been suggested that antidepressants are effective as antipanic and antiphobic agents only in depressed patients[…]

2006, Paul J. Perry, Psychotropic drug handbook, page 314:

(psychology, pharmacology) Countering panic.


falanghina

en-noun

falanghina (countable and uncountable, plural falanghinas)

From Italian falanghina, possibly derived, through Neapolitan, from Latin phalanga (“pole for carrying things”, by extension “pole for sustaining grapevine”), from Ancient Greek φᾰ́λᾰγξ (phálanx, “line, rank”), Proto-Indo-European *bʰelǵ- (“beam, plank”).

der

The light white wine produced with this type of grape.


Jack Rose

Brett did not turn up, so about quarter to six I went down to the bar and had a Jack Rose with George the barman.

1926, Ernest Hemingway, The Sun Also Rises, Folio Society, published 2008, page 66:

A cocktail made from applejack, grenadine and lemon or lime juice.


Shiga toxin

Named for Kiyoshi Shiga, who first described the bacterial origin of dysentery caused by Shigella dysenteriae.

Any of a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoid prophages.


(organic chemistry) An amphetamine that produces entactogenic and stimulant effects, used recreationally.


2C referring to the 2C drug family and B referring to bromoarenes category this drug belongs to.

2,5-dimethoxy-4-bromophenethylamine; a recreational psychedelic drug.


Rocky Mountain Kool-Aid

en-noun

Rocky Mountain Kool-Aid (plural Rocky Mountain Kool-Aids)

The beer was originally only available in Colorado.


risocaine

From [Term?] + -caine (“local anesthetic”).

(pharmacology) The local anesthetic propyl 4-aminobenzoate.


elephant dose

LL-Q1860 (eng)-Flame, not lame-elephant dose.wav

Even with an elephant dose of sedative, the horse was still kicking at him when he tried to clean the wound.

2014, Bo Brock, Crowded in the Middle of Nowhere: Tales of Humor and Healing from Rural America, Austin, Texas: Greenleaf Book Group Press, →ISBN, page 73:

She had to be put to bed with an elephant dose of tranquilizers.

1992, Gloria Dank, As the sparks fly upward, New York: Doubleday, →ISBN, page 69:


BMC

(US, beer) Initialism of Budweiser, Miller, Coors. (big three American macrobreweries)


forty-rod

From forty + rod, a measure of distance, suggesting whiskey so strong it can affect one from 200 meters away.

[…]he got powerful thirsty and clumb out on to the porch-roof and slid down a stanchion and traded his new coat for a jug of forty-rod, and clumb back again and had a good old time

1885, Mark Twain, The Adventures of Huckleberry Finn (Tom Sawyer's Comrade), Chapter V:

cheap, strong whiskey or similar alcoholic beverage


zubrowka

zubrowka (countable and uncountable, plural zubrowkas)

Borrowed from Polish żubrówka (“bison grass”), from żubr (“European bison”) + ówka.

A dry straw-colored liqueur of vodka flavored with herbs, originally from Poland.


Steinberger

Steinberger (countable and uncountable, plural Steinbergers)

A white wine from Steinberg, Kloster Eberbach.


NFV

(pharmacology) Abbreviation of nelfinavir.


reeb

reeb (countable and uncountable, plural reebs)

Business topics are discussed in a most peculiar style. One man takes the pipe from his mouth and says, "Bill made a doogheno hit this morning." "Jem," says another, to a man just entering, "you'll stand a top o' reeb?" "On," answers Jem, "I've had a trosseno tol, and have been doing dab."

1851, Henry Mayhew, “Habits and Amusements of Costermongers”, in London Labour and the London Poor, volume 1, page 11:

It is still in considerable vogue, and the enquirer will at times hear some good examples—though the chances are a hundred to one against his ever understanding them. A couple which were interpreted for my benefit were: "Hi, yob, kool that enif elrig with the nael ekom. Sap her a top of reeb and a tib of occobat," and "Islema, ogda the opperca." After the reader has sufficiently puzzled over these hieroglyphics he or she may be glad to learnt hat the quotations respectively mean: "Hi, boy, look at that fine girl with the lean moke. Pass her a pot of beer and a bit of tobacco," and "Misle, dog the copper!"

1912 May 11, A. J. Heighway, “Whitechapel”, in The Evening Post (New Zealand), volume LXXXIII, number 112, page 9:


calandria

Borrowed from Spanish calandria (“lark (bird); calander”), from Vulgar Latin *calandria, from Ancient Greek χαράδριος (kharádrios). First attested in 1886 in the sugar industry.

bor+

(brewing) A heating element within a brew kettle.


nabiximols

Another marijuana-based drug, nabiximols (Sativex), is available in Canada and several European countries to treat spasticity and nerve pain in patients with multiple sclerosis.

2021 March 8, Jane E. Brody, “Medical Marijuana Is Not Regulated as Most Medicines Are”, in The New York Times:

(pharmacology) A specific extract of Cannabis that is approved for use as a botanical drug.


peaty monster

A whisky having a very strong peaty flavour and aroma.


enzyme-inducing medication

en-noun

enzyme-inducing medication (plural enzyme-inducing medications)

A medication that induces higher concentrations of any enzyme in the blood (either by intention or as a side effect); often, more specifically, higher concentrations of liver enzymes (principally AST and ALT) in the blood.


enzyme-inhibiting medication

enzyme-inhibiting medication (plural enzyme-inhibiting medications)

Any medication that inhibits any enzyme (that is, inhibits its production, its function, or both), either by intention or as a side effect.


Hermitage

A village and civil parish in West Berkshire district, Berkshire, England (OS grid ref SU5073).

Mendocino County
Mendocino County#English

A former settlement in Mendocino County, California, United States.

Pointe Coupee Parish
Pointe Coupee Parish#English

A former community in Pointe Coupee Parish, Louisiana, United States.

A small city, the county seat of Hickory County, Missouri, United States.


beerwort

From Middle English berwort, berwurt, equivalent to beer + wort. Cognate with Dutch bierwort (“beerwort”), German Bierwürze (“beerwort”).

(brewing) Wort prepared by the infusion of malt with water, intended to be converted into beer.


gin and French

gin and French (plural gin and Frenches or gins and French or gins and Frenches)

gin and Frenches (plural)
gins and French (plural)
gins and Frenches (plural)

From the use of French as a shortened form of French vermouth, distinguished as being usually drier than Italian vermouth.

Tearle replied that gin-and-French and virginian cigarettes would do for him.

1930, Ethel Mannin, Confessions & Impressions, page 177:


FPV

(pharmacology) Abbreviation of fosamprenavir.


zythophile

From Ancient Greek ζῦθος (zûthos, “barley beer”) + -phile.

der

Downtown Riverhead is the ultimate watering hole for zythophiles, those who particularly enjoy a cold pint, with several craft breweries within walking distance of each other (or should we say, stumbling distance?).

2019 May 1, Nicole Teitler, “North Fork Brewing Stokes Craft Beer Trend: Converting former firehouse to a house of hops”, in The Independent, volume 26, number 33, East Hampton, NY, page B15:


Moscow mule

A cocktail made with vodka, ginger beer, and lime juice.


on the dry

I bumped into an old mate of mine, Bill, the other day whom I was banged up with in 1972 in St Bernard's Hospital. He's on the dry now but he told me he has had several lapses since we left muttering that it was all going to be different tomorrow.

1985 August 24, Jeffrey Bernard, “Low life: High and dry”, in The Spectator, page 34:

Then, maybe two weeks before cameras rolled, he'd put the blinkers on again and totally focus on it, and that included staying off the booze. 'I'm on the dry,' he'd announce.

2013, Robert Sellers, “A Date with Cronenburg”, in What Fresh Lunacy is This?: The Authorized Biography of Oliver Reed, Little, Brown Book Group, →ISBN, page 175:

Jessie J hasn't had an alcoholic drink since October 15, 2012. The 'Wild' singer can remember the exact date she last touched booze and claims she only ever drinks on very special occasions because alcohol leaves her lethargic and she worries it might ruin her career.

2013 July 13, “Jessie J on the dry since last October”, in Irish Examiner:

(idiomatic, informal, British, Ireland) temporarily refraining from drinking alcohol


metallopharmaceutical

(pharmacology) A pharmaceutical containing metal.


antianemic

(medicine) Preventing or countering anemia.


kasiri

Alternative form of caxiri (“alcoholic drink made from manioc/cassava”)


munkoyo

A mildly fermented drink made from pounded roots mixed with bits of maize, popular in rural Zambia.


Journey into Space

From the 1953–1958 BBC Radio science fiction programme Journey into Space.

It had been an enormous Rabelaisian bender which had taken place in the old teaching hospital in Newcastle. Huge quantities of Newcastle Brown ale, an extremely dangerous dark amber fluid known locally as ‘journey into space’ had been consumed.

2006, Peter Tate, SeaSickness, Lulu, page 30:

His other memory had been hearing people talking about ‘a journey into space’ which was how they described their local beer, Newcastle Brown! He didn’t drink, he wasn’t old enough but he remembered the saying. He had even seen the horse drawn drays carrying barrels of beer from pub to pub. ‘Journey into Space’ after an Allibone lecture was something you didn’t forget.

2012, Ralph Hill, Simon's Return, AuthorHouse, page 168:

Bobby taught woodwork at the High School, and was one of the few teachers Stan got on with. He was a Geordie exile, who still referred to Newcastle Brown Ale as "Journey into Space".

2013, Mike Brown, Thrilling, Sweet and Rotten, AuthorHouse, page 27:


meldonium

From [Term?] + -onium (“quaternary ammonium compound”).

af

(pharmacology) A drug used to treat ischemia, sometimes illicitly used by athletes to enhance performance.


blotter acid

A typical blotter acid dose contains between 30 and 150 μg of LSD per dose. Blotter papers are frequently decorated, with some examples being shown on Plates 3.1 and 3.2, and represent the dose form on which our discussion will centre.

2003, Michael D. Cole, The Analysis of Controlled Substances, John Wiley and Sons, →ISBN, page 38:

I'd dropped the mega dose of blotter acid earlier in the evening and tripped the hardest ever in my life.

2019, Flea, Acid For The Children […] , Hachette UK, →ISBN:

Blotter paper impregnated with the drug LSD, to be taken orally, and often featuring psychedelic imagery.


destruxin

(toxicology) Any of a group of mycotoxins found in Metarhizium anisopliae


chibuli

Of unknown origin, but probably derived from or influenced by the brand name Chibuku Shake Shake.

In between downing innumerable chibulies [cold beers] at the above outstanding pub, Messrs Hulley, Geddes and Dennison decided that the showgrounds would be just about adequate accommodation for the baby battalion, so the move was undertaken in early November.

1989, The War Diaries of André Dennison, page 18:

Those brown boot bastards are already in the club sucking up a chibuli," Ormonde growled.

2013, Douglas Hubbard, Jr., Bound for Africa: Cold War Fight Along the Zambezi:

"Sure. Garikayi!" he called. "Bring some fucking cold chibulis here."


Cab

en-noun

Cab (countable and uncountable, plural Cabs)

“So you're drinking some Cabs then, right?” she asked. ¶ I told her that indeed I was. […] Cabernet Sauvignon grows just about anywhere; nearly every wine-growing country has its Cab.

2005, Maureen Christian Petrosky, The Wine Club: A Month-by-Month Guide to Learning about Wine with Friends, Des Moines, IA: Meredith Books, →ISBN, page 34:

Cabernet Sauvignon
Cabernet Sauvignon#English

Abbreviation of Cabernet Sauvignon wine.


pyrrolidinophenone

Any of a class of recreational designer drugs with psychostimulant effects.


Kindzmarauli

Borrowed from Georgian ქინძმარაული (kinʒmarauli).

A semi-sweet red wine, produced in Kakheti, Georgia.


Akhasheni

Borrowed from Georgian ახაშენი (axašeni).

A semi-sweet red wine, produced around Akhasheni.


Mukuzani

Borrowed from Georgian მუკუზანი (muḳuzani).

A dry red wine, produced around Mukuzani.


Khvanchkara

Borrowed from Georgian ხვანჭკარა (xvanč̣ḳara).

A semi-sweet red wine, produced around Khvanchkara.