See metachromatic leukodystrophy on Wiktionary
Download JSON data for metachromatic leukodystrophy meaning in All languages combined (4.5kB)
{
"forms": [
{
"form": "metachromatic leukodystrophies",
"tags": [
"plural"
]
}
],
"head_templates": [
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"args": {},
"expansion": "metachromatic leukodystrophy (plural metachromatic leukodystrophies)",
"name": "en-noun"
}
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"lang": "English",
"lang_code": "en",
"pos": "noun",
"senses": [
{
"categories": [
{
"kind": "topical",
"langcode": "en",
"name": "Medicine",
"orig": "en:Medicine",
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"source": "w"
},
{
"_dis": "50 50",
"kind": "other",
"name": "English entries with incorrect language header",
"parents": [
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"Entry maintenance"
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"source": "w+disamb"
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"examples": [
{
"ref": "2010, Michael C. Brodsky, Pediatric Neuro-Ophthalmology, Springer, page 478",
"text": "Metachromatic leukodystrophy is an autosomal recessive disorder that is usually caused by mutations in the arylsulfatase A (ARSA) gene on chromosome 22q13.31.[…]Several molecular forms of arylsulfatase A exist and may account for the different phenotypes of metachromatic leukodystrophy.",
"type": "quotation"
},
{
"ref": "2013, Perry K. Richardson, Scott T. Demarest, “27: Inherited Metabolic Neuropathies”, in Bashar Katirji, Henry J. Kaminski, Robert L. Ruff, editors, Neuromuscular Disorders in Clinical Practice, Springer, page 558",
"text": "The leukodystrophies are lysosomal storage disorders (lipidoses) affecting myelin. The metachromatic leukodystrophies (MLD) are a heterogeneous group of disorders characterized by demyelination in the central and peripheral nervous system and accumulation of galactosyl sulfatide (cerebroside sulfate) in glia, Schwann cells, and macrophages.",
"type": "quotation"
},
{
"ref": "2014, Juan M Bilbao, Robert E Schmidt, Biopsy Diagnosis of Peripheral Neuropathy, Springer, page 429",
"text": "The metachromatic leukodystrophies (MLD) are caused by defective activity of the arylsulfatase enzyme system, with a consequent accumulation of sulfatides. The most common variant (Phenotype MIM#250100) is caused by a defect in the arylsulfatase A gene (ARSA, protein product cerebroside sulfatase).",
"type": "quotation"
}
],
"glosses": [
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\nespecially, a deficiency in the enzyme ARSA (arylsulfatase A).",
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,"
],
"id": "en-metachromatic_leukodystrophy-en-noun-Cp-H2W9S",
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[
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],
"raw_glosses": [
"(medicine) Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\n"
],
"topics": [
"medicine",
"sciences"
]
},
{
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{
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"source": "w+disamb"
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],
"glosses": [
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\nespecially, a deficiency in the enzyme ARSA (arylsulfatase A).",
"especially, a deficiency in the enzyme ARSA (arylsulfatase A)."
],
"id": "en-metachromatic_leukodystrophy-en-noun-a65vmWvh",
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[
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"raw_glosses": [
"(medicine) Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\n"
],
"topics": [
"medicine",
"sciences"
]
}
],
"synonyms": [
{
"_dis1": "50 50",
"sense": "genetic metabolic disorder",
"word": "MLD"
},
{
"_dis1": "50 50",
"sense": "genetic metabolic disorder",
"word": "ARSA deficiency"
},
{
"_dis1": "50 50",
"sense": "genetic metabolic disorder",
"word": "Arylsulfatase A deficiency"
}
],
"translations": [
{
"_dis1": "50 50",
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"feminine"
],
"word": "leucodistrofia metacromatica"
},
{
"_dis1": "50 50",
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"feminine"
],
"word": "malattia di Scholz"
},
{
"_dis1": "50 50",
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"masculine"
],
"word": "deficit di Arilsulfatasi"
}
],
"wikipedia": [
"metachromatic leukodystrophy"
],
"word": "metachromatic leukodystrophy"
}
{
"categories": [
"English countable nouns",
"English entries with incorrect language header",
"English lemmas",
"English multiword terms",
"English nouns"
],
"forms": [
{
"form": "metachromatic leukodystrophies",
"tags": [
"plural"
]
}
],
"head_templates": [
{
"args": {},
"expansion": "metachromatic leukodystrophy (plural metachromatic leukodystrophies)",
"name": "en-noun"
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],
"lang": "English",
"lang_code": "en",
"pos": "noun",
"senses": [
{
"categories": [
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],
"examples": [
{
"ref": "2010, Michael C. Brodsky, Pediatric Neuro-Ophthalmology, Springer, page 478",
"text": "Metachromatic leukodystrophy is an autosomal recessive disorder that is usually caused by mutations in the arylsulfatase A (ARSA) gene on chromosome 22q13.31.[…]Several molecular forms of arylsulfatase A exist and may account for the different phenotypes of metachromatic leukodystrophy.",
"type": "quotation"
},
{
"ref": "2013, Perry K. Richardson, Scott T. Demarest, “27: Inherited Metabolic Neuropathies”, in Bashar Katirji, Henry J. Kaminski, Robert L. Ruff, editors, Neuromuscular Disorders in Clinical Practice, Springer, page 558",
"text": "The leukodystrophies are lysosomal storage disorders (lipidoses) affecting myelin. The metachromatic leukodystrophies (MLD) are a heterogeneous group of disorders characterized by demyelination in the central and peripheral nervous system and accumulation of galactosyl sulfatide (cerebroside sulfate) in glia, Schwann cells, and macrophages.",
"type": "quotation"
},
{
"ref": "2014, Juan M Bilbao, Robert E Schmidt, Biopsy Diagnosis of Peripheral Neuropathy, Springer, page 429",
"text": "The metachromatic leukodystrophies (MLD) are caused by defective activity of the arylsulfatase enzyme system, with a consequent accumulation of sulfatides. The most common variant (Phenotype MIM#250100) is caused by a defect in the arylsulfatase A gene (ARSA, protein product cerebroside sulfatase).",
"type": "quotation"
}
],
"glosses": [
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\nespecially, a deficiency in the enzyme ARSA (arylsulfatase A).",
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,"
],
"links": [
[
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],
[
"genetic",
"genetic"
],
[
"metabolic",
"metabolic"
],
[
"ARSA",
"ARSA"
],
[
"arylsulfatase",
"arylsulfatase"
]
],
"raw_glosses": [
"(medicine) Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\n"
],
"topics": [
"medicine",
"sciences"
]
},
{
"categories": [
"English terms with quotations",
"en:Medicine"
],
"glosses": [
"Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\nespecially, a deficiency in the enzyme ARSA (arylsulfatase A).",
"especially, a deficiency in the enzyme ARSA (arylsulfatase A)."
],
"links": [
[
"medicine",
"medicine"
],
[
"genetic",
"genetic"
],
[
"metabolic",
"metabolic"
],
[
"ARSA",
"ARSA"
],
[
"arylsulfatase",
"arylsulfatase"
]
],
"raw_glosses": [
"(medicine) Any of a range of genetic metabolic disorders caused by defective genes for arylsulfatase enzymes,\n"
],
"topics": [
"medicine",
"sciences"
]
}
],
"synonyms": [
{
"sense": "genetic metabolic disorder",
"word": "MLD"
},
{
"sense": "genetic metabolic disorder",
"word": "ARSA deficiency"
},
{
"sense": "genetic metabolic disorder",
"word": "Arylsulfatase A deficiency"
}
],
"translations": [
{
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"feminine"
],
"word": "leucodistrofia metacromatica"
},
{
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"feminine"
],
"word": "malattia di Scholz"
},
{
"code": "it",
"lang": "Italian",
"sense": "genetic metabolic disorder",
"tags": [
"masculine"
],
"word": "deficit di Arilsulfatasi"
}
],
"wikipedia": [
"metachromatic leukodystrophy"
],
"word": "metachromatic leukodystrophy"
}
This page is a part of the kaikki.org machine-readable All languages combined dictionary. This dictionary is based on structured data extracted on 2024-04-30 from the enwiktionary dump dated 2024-04-21 using wiktextract (210104c and c9440ce). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.
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